Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Rachel L Edwards"'
Autor:
Justin J Miller, Ishaan T Shah, Jayda Hatten, Yasaman Barekatain, Elizabeth A Mueller, Ahmed M Moustafa, Rachel L Edwards, Cynthia S Dowd, Geoffrey C Hoops, R Jeremy Johnson, Paul Planet, Florian L Muller, Joseph Jez, Audrey R Odom John
Publikováno v:
eLife, Vol 10 (2021)
Externí odkaz:
https://doaj.org/article/98f3fd68d1a542c2816442fd7398b063
Autor:
Justin J Miller, Ishaan T Shah, Jayda Hatten, Yasaman Barekatain, Elizabeth A Mueller, Ahmed M Moustafa, Rachel L Edwards, Cynthia S Dowd, Geoffrey C Hoops, R Jeremy Johnson, Paul J Planet, Florian L Muller, Joseph M Jez, Audrey R Odom John
Publikováno v:
eLife, Vol 10 (2021)
Carboxy ester prodrugs are widely employed to increase oral absorption and potency of phosphonate antibiotics. Prodrugging can mask problematic chemical features that prevent cellular uptake and may enable tissue-specific compound delivery. However,
Externí odkaz:
https://doaj.org/article/17f733fe025245b6a2dbe45ff732edb9
Autor:
Rachel L Edwards, Isabel Heueck, Soon Goo Lee, Ishaan T Shah, Justin J Miller, Andrew J Jezewski, Marwa O Mikati, Xu Wang, Robert C Brothers, Kenneth M Heidel, Damon M Osbourn, Carey-Ann D Burnham, Sophie Alvarez, Stephanie A Fritz, Cynthia S Dowd, Joseph M Jez, Audrey R Odom John
Publikováno v:
PLoS Pathogens, Vol 16, Iss 6, p e1007806 (2020)
Coagulase-positive staphylococci, which frequently colonize the mucosal surfaces of animals, also cause a spectrum of opportunistic infections including skin and soft tissue infections, urinary tract infections, pneumonia, and bacteremia. However, re
Externí odkaz:
https://doaj.org/article/5dc53d519c85411dae65c54b8c5190b9
Autor:
Nina F Gnädig, Barbara H Stokes, Rachel L Edwards, Gavreel F Kalantarov, Kim C Heimsch, Michal Kuderjavy, Audrey Crane, Marcus C S Lee, Judith Straimer, Katja Becker, Ilya N Trakht, Audrey R Odom John, Sachel Mok, David A Fidock
Publikováno v:
PLoS Pathogens, Vol 16, Iss 4, p e1008482 (2020)
The emergence of artemisinin (ART) resistance in Plasmodium falciparum intra-erythrocytic parasites has led to increasing treatment failure rates with first-line ART-based combination therapies in Southeast Asia. Decreased parasite susceptibility is
Externí odkaz:
https://doaj.org/article/63f0cf7a413247b28ca9b575fa65febb
Autor:
Monique R Heitmeier, Richard C Hresko, Rachel L Edwards, Michael J Prinsen, Ma Xenia G Ilagan, Audrey R Odom John, Paul W Hruz
Publikováno v:
PLoS ONE, Vol 14, Iss 5, p e0216457 (2019)
Although the Plasmodium falciparum hexose transporter PfHT has emerged as a promising target for anti-malarial therapy, previously identified small-molecule inhibitors have lacked promising drug-like structural features necessary for development as c
Externí odkaz:
https://doaj.org/article/5b482186f44d47e980b0f7cc11450eff
Autor:
Ryan C. Henrici, Rachel L. Edwards, Martin Zoltner, Donelly A. van Schalkwyk, Melissa N. Hart, Franziska Mohring, Robert W. Moon, Stephanie D. Nofal, Avnish Patel, Christian Flueck, David A. Baker, Audrey R. Odom John, Mark C. Field, Colin J. Sutherland
Publikováno v:
mBio, Vol 11, Iss 1 (2020)
ABSTRACT The efficacy of current antimalarial drugs is threatened by reduced susceptibility of Plasmodium falciparum to artemisinin, associated with mutations in pfkelch13. Another gene with variants known to modulate the response to artemisinin enco
Externí odkaz:
https://doaj.org/article/783ffd262b134205b1f7de614ed72d61
Autor:
Rachel L. Edwards, Robert C. Brothers, Xu Wang, Maxim I. Maron, Peter D. Ziniel, Patricia S. Tsang, Thomas E. Kraft, Paul W. Hruz, Kim C. Williamson, Cynthia S. Dowd, Audrey R. Odom John
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract The emergence of Plasmodium falciparum resistant to frontline therapeutics has prompted efforts to identify and validate agents with novel mechanisms of action. MEPicides represent a new class of antimalarials that inhibit enzymes of the met
Externí odkaz:
https://doaj.org/article/539d6d0aabfc46c68f5a489b64e29fac
Autor:
Sandra Johannsen, Robin M. Gierse, Arne Krüger, Rachel L. Edwards, Vittoria Nanna, Anna Fontana, Di Zhu, Tizina Masini, Lais Pessanha de Carvalho, Mael Poizat, Bart Kieftenbelt, Dana M. Hodge, Sophie Alvarez, Daan Bunt, Kamila Anna Meissner, Edmarcia Elisa de Souza, Melloney Dröge, Bernard van Vliet, Jack de Hartog, Michael C. Hutter, Jana Held, Audrey R. Odom John, Carsten Wrenger, Anna K. H. Hirsch
In this study, we identified three novel compound classes with potent activity against Plasmodium falciparum, the most dangerous human malarial parasite. Resistance of this pathogen to known drugs is increasing and compounds with different modes of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::968d2b347432557d44f960aef4313c60
https://doi.org/10.26434/chemrxiv-2022-npslc
https://doi.org/10.26434/chemrxiv-2022-npslc
Autor:
Rachel L. Edwards, Audrey R. Odom John
Publikováno v:
F1000Research, Vol 5 (2016)
In the past decade, malaria rates have plummeted as a result of aggressive infection control measures and the adoption of artemisinin-based combination therapies (ACTs). However, a potential crisis looms ahead. Treatment failures to standard antimala
Externí odkaz:
https://doaj.org/article/33fdaa6df73e470a80a764868a07e2e8
Autor:
R. Jeremy Johnson, Elizabeth A. Mueller, Jayda Hatten, Joseph M. Jez, Rachel L. Edwards, Geoffrey C. Hoops, Ahmed M Moustafa, Florian L. Muller, Ishaan T. Shah, Yasaman Barekatain, Cynthia S. Dowd, Paul J. Planet, Audrey R. Odom John, Justin J. Miller
Publikováno v:
eLife, Vol 10 (2021)
eLife
eLife
Carboxy ester prodrugs are widely employed to increase oral absorption and potency of phosphonate antibiotics. Prodrugging can mask problematic chemical features that prevent cellular uptake and may enable tissue-specific compound delivery. However,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c74c98727b666ca172619baae03b4cb
https://elifesciences.org/articles/75743
https://elifesciences.org/articles/75743