Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Rachel L, Palte"'
Autor:
Rachel L. Palte, Veronica Juan, Yacob Gomez-Llorente, Marc Andre Bailly, Kalyan Chakravarthy, Xun Chen, Daniel Cipriano, Laurence Fayadat-Dilman, Symon Gathiaka, Heiko Greb, Brian Hall, Mas Handa, Mark Hsieh, Esther Kofman, Heping Lin, J. Richard Miller, Nhung Nguyen, Jennifer O’Neil, Hussam Shaheen, Eric Sterner, Corey Strickland, Angie Sun, Shane Taremi, Giovanna Scapin
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
Palte et al provide cryo-EM structures of five potent and inhibitory monoclonal antibodies bound to human Arginase 1, a T-cell modulating metalloenzyme and a cancer drug target. They provide structural insights that will aid in the evaluation of thes
Externí odkaz:
https://doaj.org/article/fbf41ee3e220482a9ea5fcab675f2be6
Autor:
Rachel L. Palte, Veronica Juan, Yacob Gomez-Llorente, Marc Andre Bailly, Kalyan Chakravarthy, Xun Chen, Daniel Cipriano, Ghassan N. Fayad, Laurence Fayadat-Dilman, Symon Gathiaka, Heiko Greb, Brian Hall, Mas Handa, Mark Hsieh, Esther Kofman, Heping Lin, J. Richard Miller, Nhung Nguyen, Jennifer O’Neil, Hussam Shaheen, Eric Sterner, Corey Strickland, Angie Sun, Shane Taremi, Giovanna Scapin
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-2 (2021)
Externí odkaz:
https://doaj.org/article/15828ecf3c6a4e49a73581c4631d3a3d
Autor:
David A. Candito, Vladimir Simov, Anmol Gulati, Solomon Kattar, Ryan W. Chau, Blair T. Lapointe, Joey L. Methot, Duane E. DeMong, Thomas H. Graham, Ravi Kurukulasuriya, Mitchell H. Keylor, Ling Tong, Gregori J. Morriello, John J. Acton, Barbara Pio, Weiguo Liu, Jack D. Scott, Michael J. Ardolino, Theodore A. Martinot, Matthew L. Maddess, Xin Yan, Hakan Gunaydin, Rachel L. Palte, Spencer E. McMinn, Lisa Nogle, Hongshi Yu, Ellen C. Minnihan, Charles A. Lesburg, Ping Liu, Jing Su, Laxminarayan G. Hegde, Lily Y. Moy, Janice D. Woodhouse, Robert Faltus, Tina Xiong, Paul Ciaccio, Jennifer A. Piesvaux, Karin M. Otte, Matthew E. Kennedy, David Jonathan Bennett, Erin F. DiMauro, Matthew J. Fell, Santhosh Neelamkavil, Harold B. Wood, Peter H. Fuller, J. Michael Ellis
Publikováno v:
Journal of Medicinal Chemistry. 65:16801-16817
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::365ba0e1a6a6d085b4344b637344b726
https://doi.org/10.1021/acs.jmedchem.2c01605
https://doi.org/10.1021/acs.jmedchem.2c01605
Autor:
Anandan Palani, Matthew Lloyd Childers, Qinglin Pu, Matthew J. Mitcheltree, Symon Gathiaka, Christian Fischer, Lisa Nogle, Rachel L. Palte, Jared N. Cumming, J. Richard Miller, Spencer McMinn, Hai-Young Kim, Hongjun Zhang, Charles A. Lesburg, Adam Beard, Donovon A. Adpressa, Josep Saurí, Derun Li, Theodore A. Martinot, Thomas W. Lyons, David L. Sloman, Jialiang Wang, Peter Spacciapoli, Min Lu, Abdelghani Achab
Publikováno v:
ACS Med Chem Lett
[Image: see text] Comprehensive synthetic strategies afforded a diverse set of structurally unique bicyclic proline-containing arginase inhibitors with a high degree of three-dimensionality. The analogs that favored the Cγ-exo conformation of the pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::355a3f9279f9db6a241567d164d50d64
https://doi.org/10.1021/acsmedchemlett.1c00258
https://doi.org/10.1021/acsmedchemlett.1c00258
Autor:
David A Candito, David J. Witter, Josep Saurí, Yu-hong Lam, Surendra B Gadamsetty, Michael H. Reutershan, Yingchun Ye, Ryan V Quiroz, Sebastian Schneider, Rachel L. Palte, Hongming Li
Publikováno v:
The Journal of Organic Chemistry. 86:5142-5151
In the context of a PRMT5 inhibitor program, we describe our efforts to develop a flexible and robust strategy to access tetrahydrofuro[3,4-b]furan nucleoside analogues. Ultimately, it was found that a Wolfe type carboetherification from an alkenol d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2be696853f7f2484c20fd532369afef9
https://doi.org/10.1021/acs.joc.0c02969
https://doi.org/10.1021/acs.joc.0c02969
Autor:
Symon Gathiaka, Rachel L. Palte, Sung-Sau So, Xiaomei Chai, J. Richard Miller, Reshma Kuvelkar, Xiujuan Wen, Steven Cifelli, Anthony Kreamer, Andy Liaw, David G. McLaren, Christian Fischer
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 84:129193
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c378db3e1bdb5153da20aabe9eb4d7c5
https://doi.org/10.1016/j.bmcl.2023.129193
https://doi.org/10.1016/j.bmcl.2023.129193
Autor:
Matthew J. Mitcheltree, Theodore A. Martinot, Thomas W. Lyons, Spencer McMinn, Peter W. Fan, Hyelim Cho, Christian Fischer, Kalyan Chakravarthy, David L. Sloman, Padmanabhan Eangoor, Jared N. Cumming, Charles A. Lesburg, Mangeng Cheng, Adam Beard, Derun Li, Hongjun Zhang, Jennifer O'Neil, Abdelghani Achab, Rachel L. Palte, Anandan Palani, J. Richard Miller, Josep Saurí, Symon Gathiaka, Hai-Young Kim
Publikováno v:
ACS Med Chem Lett
[Image: see text] The action of arginase, a metalloenzyme responsible for the hydrolysis of arginine to urea and ornithine, is hypothesized to suppress immune-cell activity within the tumor microenvironment, and thus its inhibition may constitute a m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bf7e118f47c67e176705e85f740b968
https://doi.org/10.1021/acsmedchemlett.0c00058
https://doi.org/10.1021/acsmedchemlett.0c00058
Autor:
Matthew H. Daniels, Sunil Nagpal, Blair T. Lapointe, Jos Cals, Mario van der Stelt, Vladimir Simov, Willem Jan Karstens, Sujal V. Deshmukh, Kenneth Jay Barr, J. Richard Miller, Hans van Eenenaam, Craig C. Correll, John Maclean, Laxminarayan G Hegde, Lily Y. Moy, B. Wesley Trotter, Rachel L. Palte, Janice D Woodhouse, Nunzio Sciammetta, Gopal Parthasarathy, Heidi Ferguson, Rita Azevedo, Hongjun Zhang, Arthur Oubrie, Neville J. Anthony
Publikováno v:
ACS Medicinal Chemistry Letters. 11:114-119
The clinical success of anti-IL-17 monoclonal antibodies (i.e., Cosentyx and Taltz) has validated Th17 pathway modulation for the treatment of autoimmune diseases. The nuclear hormone receptor RORγt is a master regulator of Th17 cells and affects th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::927a9a20903f38d39770d2e5897d3e47
https://doi.org/10.1021/acsmedchemlett.9b00431
https://doi.org/10.1021/acsmedchemlett.9b00431
Autor:
Mitchell H. Keylor, Anmol Gulati, Solomon D. Kattar, Rebecca E. Johnson, Ryan W. Chau, Kaila A. Margrey, Michael J. Ardolino, Cayetana Zarate, Kelsey E. Poremba, Vladimir Simov, Gregori J. Morriello, John J. Acton, Barbara Pio, Xin Yan, Rachel L. Palte, Spencer E. McMinn, Lisa Nogle, Charles A. Lesburg, Donovon Adpressa, Shishi Lin, Santhosh Neelamkavil, Ping Liu, Jing Su, Laxminarayan G. Hegde, Janice D. Woodhouse, Robert Faltus, Tina Xiong, Paul J. Ciaccio, Jennifer Piesvaux, Karin M. Otte, Harold B. Wood, Matthew E. Kennedy, David Jonathan Bennett, Erin F. DiMauro, Matthew J. Fell, Peter H. Fuller
Publikováno v:
Journal of medicinal chemistry. 65(1)
The leucine-rich repeat kinase 2 (LRRK2) protein has been genetically and functionally linked to Parkinson's disease (PD), a disabling and progressive neurodegenerative disorder whose current therapies are limited in scope and efficacy. In this repor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6720c280fccf3e18653a864a196348ad
https://pubmed.ncbi.nlm.nih.gov/34967623
https://pubmed.ncbi.nlm.nih.gov/34967623
Autor:
Laurence Fayadat-Dilman, Jennifer O'Neil, Hussam Hisham Shaheen, Ghassan N. Fayad, Heping Lin, S. Shane Taremi, Giovanna Scapin, Corey Strickland, Heiko Greb, Nhung Nguyen, Symon Gathiaka, Mas Handa, Daniel Cipriano, Rachel L. Palte, Brian Hall, Eric Sterner, Veronica Juan, Esther Kofman, Xun Chen, Kalyan Chakravarthy, Yacob Gomez-Llorente, Mark Hsieh, J. Richard Miller, Angie Sun, Marc Andre Bailly
Publikováno v:
Communications Biology
Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
Human Arginase 1 (hArg1) is a metalloenzyme that catalyzes the hydrolysis of l-arginine to l-ornithine and urea, and modulates T-cell-mediated immune response. Arginase-targeted therapies have been pursued across several disease areas including immun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9236021a6a0eb417fbe5a119ad6b9d7a
https://doi.org/10.1038/s42003-021-02444-z
https://doi.org/10.1038/s42003-021-02444-z