Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Rachel K. Hoyles"'
Autor:
Emma Derrett-Smith, Kristina E. N. Clark, Xu Shiwen, David J. Abraham, Rachel K. Hoyles, Olivier Lacombe, Pierre Broqua, Jean Louis Junien, Irena Konstantinova, Voon H. Ong, Christopher P. Denton
Publikováno v:
Arthritis Research & Therapy, Vol 23, Iss 1, Pp 1-13 (2021)
Abstract Background The TβRII∆k-fib transgenic (TG) mouse model of scleroderma replicates key fibrotic and vasculopathic complications of systemic sclerosis through fibroblast-directed upregulation of TGFβ signalling. We have examined peroxisome
Externí odkaz:
https://doaj.org/article/29917a595917451aa674f32d4bacb9c8
Autor:
Sophie V. Fletcher, Mark G. Jones, Elizabeth A. Renzoni, Helen Parfrey, Rachel K. Hoyles, Katherine Spinks, Maria Kokosi, Apollinaris Kwok, Chris Warburton, Vanessa Titmuss, Muhunthan Thillai, Nicola Simler, Toby M. Maher, Christopher J. Brereton, Felix Chua, Athol U. Wells, Luca Richeldi, Lisa G. Spencer
Publikováno v:
ERJ Open Research, Vol 4, Iss 4 (2018)
Externí odkaz:
https://doaj.org/article/b982002054c04350a15a154b527fa186
Autor:
Toby M Maher, Veronica A Tudor, Peter Saunders, Fernando Zanghelini, Carlota Grossi Sampedro, Georgios Xydopoulos, Michael Gibbons, Sophie V Fletcher, Christopher P Denton, Maria Kokosi, Rachel K Hoyles, Helen Parfrey, Elisabetta A Renzoni, Athol U Wells, Deborah Ashby, Richard J Fordham, Matyas Szigeti, Philip L Molyneaux
Publikováno v:
Efficacy and Mechanism Evaluation, Vol 11, Iss 04 (2024)
Background Interstitial lung disease frequently complicates systemic autoimmune disorders including scleroderma, idiopathic inflammatory myositis and mixed connective tissue disease, resulting in considerable morbidity and mortality. Based on the res
Externí odkaz:
https://doaj.org/article/e6fce1fb145949bfbbfaa25f5a601c57
Publikováno v:
BMJ Open Respiratory Research, Vol 10, Iss 1 (2023)
Background Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic lung disease with poor prognosis. Clinical studies have demonstrated association between different blood leucocytes and mortality and forced vital capacity (FVC) decline. Here,
Externí odkaz:
https://doaj.org/article/43f9a5fe74eb4316bfd032ab260161fc
Autor:
David Abraham, Rachel K. Hoyles, Irena Konstantinova, Emma Derrett-Smith, Kristina E N Clark, Jean Louis Junien, Xu Shiwen, Voon H Ong, Christopher P. Denton, Pierre Broqua, Olivier Lacombe
Publikováno v:
Arthritis Research & Therapy, Vol 23, Iss 1, Pp 1-13 (2021)
Arthritis Research & Therapy
Arthritis Research & Therapy
Background The TβRII∆k-fib transgenic (TG) mouse model of scleroderma replicates key fibrotic and vasculopathic complications of systemic sclerosis through fibroblast-directed upregulation of TGFβ signalling. We have examined peroxisome prolifera
Autor:
Puja Mehta, Rachel K Hoyles, Harsha Gunawardena, Bibek Gooptu, Nazia Chaudhuri, Melissa J Heightmann, Helen Garthwaite, Henry Penn, Arnab Datta, Shahir Hamdulay, Boris Lams, Sangita Agarwal, Melissa Wickremesinghe, Gisli Jenkins, Joanna C Porter, Christopher P Denton
Publikováno v:
Mehta, P, Hoyles, R K, Gunawardena, H, Gooptu, B, Chaudhuri, N, Heightmann, M J, Garthwaite, H, Penn, H, Datta, A, Hamdulay, S, Lams, B, Agarwal, S, Wickremesinghe, M, Jenkins, G, Porter, J C & Denton, C P 2022, ' Rheumatologists have an important role in the management of interstitial lung disease (ILD) : a cross-speciality, multi-centre, UK perspective ', Rheumatology (Oxford, England), vol. 61, no. 5, pp. 1748-1751 . https://doi.org/10.1093/rheumatology/keac061
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4788827f70dafd422803c937e994cfa
https://doi.org/10.1093/rheumatology/keac061
https://doi.org/10.1093/rheumatology/keac061
Autor:
Maria Kokosi, Toby M. Maher, Felix Chua, Athol U. Wells, Rachel K. Hoyles, Vasilis Kouranos, Peter M. George, Jackie Donovan, Veronica Alfieri, Dina Visca, Philip L. Molyneaux, Angelo De Lauretis, Cécile Daccord, George Margaritopoulos, Christopher P. Denton, Elisabetta A. Renzoni, David Abraham, Carmel Stock, Voon H Ong, Piersante Sestini
Publikováno v:
Respirology. 26:461-468
Background and objective The course of systemic sclerosis-associated interstitial lung disease (SSc-ILD) is highly variable, and accurate prognostic markers are needed. KL-6 is a mucin-like glycoprotein (MUC1) expressed by type II pneumocytes, while
Autor:
Toby M Maher, Veronica A Tudor, Peter Saunders, Michael A Gibbons, Sophie V Fletcher, Christopher P Denton, Rachel K Hoyles, Helen Parfrey, Elisabetta A Renzoni, Maria Kokosi, Athol U Wells, Deborah Ashby, Matyas Szigeti, Philip L Molyneaux, Mohammed Akil, Daphne Babalis, Nazia Chaudhuri, Felix Chua, Arnab Data, Dhananjay Desai, Shrish Dubey, Natalie Dwyer, Marcus Flather, Richard Fordham, Carlota Grossi Sampedro, Frances Hall, Ira Jakupovic, Gregory Keir, Bipen Patel, Henry Penn, Arvind Rajasekaran, Lisa G Spencer, Vicky Tsipouri, Zhe Wu, Georgio Xydopoulos, Fernando Zanghelini
Publikováno v:
The Lancet. Respiratory medicine. 11(1)
Background: rituximab is often used as rescue therapy in interstitial lung disease (ILD) associated with connective tissue disease (CTD), but has not been studied in clinical trials. This study aimed to assess whether rituximab is superior to cycloph
Autor:
Joshua J Solomon, Sonye K Danoff, Felix A Woodhead, Shelley Hurwitz, Rie Maurer, Ian Glaspole, Paul F Dellaripa, Bibek Gooptu, Robert Vassallo, P Gerard Cox, Kevin R Flaherty, Huzaifa I Adamali, Michael A Gibbons, Lauren Troy, Ian A Forrest, Joseph A Lasky, Lisa G Spencer, Jeffrey Golden, Mary Beth Scholand, Nazia Chaudhuri, Mark A Perrella, David A Lynch, Daniel C Chambers, Martin Kolb, Cathie Spino, Ganesh Raghu, Hilary J Goldberg, Ivan O Rosas, Shana Haynes-Harp, Fernando Poli, Coimbatore Sree Vidya, Rebecca R. Baron, Timothy Clouser, Tracy Doyle, Anthony Maeda, Kristin B. Highland, Jemima F. Albayda, Sarah E. Collins, Karthik S. Suresh, John M. Davis, Andrew H. Limper, Isabel Amigues, Kristina Eliopoulos, Jeffery J. Swigris, Stephen Humphries, John C. Huntwork, Chris Glynn, Steve R. Duncan, Maria I. Danila, Marilyn K. Glassberg, Elana M. Oberstein, Elizabeth A. Belloli, Linda Briggs, Vivek Nagaraja, Linda Cholewa, Donna DiFranco, Edward Green, Christie Liffick, Tanvi Naik, Genevieve Montas, Dorota Lebiedz-Odrobina, Reba Bissell, Mark Wener, Lisa H. Lancaster, Leslie J. Crawford, Karmela Chan, Robert J. Kaner, Alicia Morris, Xiaoping Wu, Nader A. Khalidi, Christopher J. Ryerson, Alyson W. Wong, Charlene D. Fell, Sharon A. LeClercq, Mark Hyman, Shane Shapera, Shikha Mittoo, Shireen Shaffu, Karl Gaffney, Andrew M. Wilson, Shaney Barratt, Harsha Gunawardena, Rachel K. Hoyles, Joel David, Namrata Kewalramani, Toby M. Maher, Philip L. Molyneaux, Maria A. Kokosi, Matthew J. Cates, Mandizha Mandizha, Abdul Ashish, Gladstone Chelliah, Helen Parfrey, Muhunthan Thillai, Josephine Vila, Sophie V. Fletcher, Paul Beirne, Clair Favager, Jo Brown, Julie K. Dawson, Pilar Rivera Ortega, Sahena Haque, Pippa Watson, Jun K. Khoo, Karen Symons, Peter Youssef, John A. Mackintosh
Publikováno v:
The Lancet. Respiratory medicine.
Interstitial lung disease is a known complication of rheumatoid arthritis, with a lifetime risk of developing the disease in any individual of 7·7%. We aimed to assess the safety, tolerability, and efficacy of pirfenidone for the treatment of patien
Neutrophil lymphocyte ratio as an indicator for disease progression in Idiopathic Pulmonary Fibrosis
Autor:
Andrew Achaiah, Amila Rathnapala, Andrea Pereira, Harriet Bothwell, Kritica Dwivedi, Rosie Barker, Valentina Iotchkova, Rachel Benamore, Rachel K Hoyles, Ling-Pei Ho
Publikováno v:
BMJ open respiratory research. 9(1)
RationaleIdiopathic pulmonary fibrosis (IPF) is a progressive fibrotic lung disease. Patients present at different stages and disease course is varied. Blood monocytes have been linked to all-cause mortality, and neutrophils to progression to IPF in