Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Rachel K Szilard"'
Autor:
Jonah Beenstock, Samara Mishelle Ona, Jennifer Porat, Stephen Orlicky, Leo C. K. Wan, Derek F. Ceccarelli, Pierre Maisonneuve, Rachel K. Szilard, Zhe Yin, Dheva Setiaputra, Daniel Y. L. Mao, Morgan Khan, Shaunak Raval, David C. Schriemer, Mark A. Bayfield, Daniel Durocher, Frank Sicheri
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
KEOPS is an evolutionary conserved complex with a core of four core subunits—Pcc1, Kae1, Bud32 and Cgi121—that catalyzes the universal and essential tRNA modification N6-threonylcarbamoyl adenosine (t6A). Here the authors describe a Cgi121-tRNA c
Externí odkaz:
https://doaj.org/article/7cf78e57b0794aac8b3b0de7021b5c2b
Autor:
David Gallo, Jordan T. F. Young, Jimmy Fourtounis, Giovanni Martino, Alejandro Álvarez-Quilón, Cynthia Bernier, Nicole M. Duffy, Robert Papp, Anne Roulston, Rino Stocco, Janek Szychowski, Artur Veloso, Hunain Alam, Prasamit S. Baruah, Alexanne Bonneau Fortin, Julian Bowlan, Natasha Chaudhary, Jessica Desjardins, Evelyne Dietrich, Sara Fournier, Chloe Fugère-Desjardins, Theo Goullet de Rugy, Marie-Eve Leclaire, Bingcan Liu, Vivek Bhaskaran, Yael Mamane, Henrique Melo, Olivier Nicolas, Akul Singhania, Rachel K. Szilard, Ján Tkáč, Shou Yun Yin, Stephen J. Morris, Michael Zinda, C. Gary Marshall, Daniel Durocher
Publikováno v:
Nature. 604:749-756
Amplification of the CCNE1 locus on chromosome 19q12 is prevalent in multiple tumour types, particularly in high-grade serous ovarian cancer, uterine tumours and gastro-oesophageal cancers, where high cyclin E levels are associated with genome instab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc789be54b458503be76fad03b732048
https://doi.org/10.1038/s41586-022-04638-9
https://doi.org/10.1038/s41586-022-04638-9
Autor:
Jonathan Strecker, Sonia Stinus, Mariana Pliego Caballero, Rachel K Szilard, Michael Chang, Daniel Durocher
Publikováno v:
eLife, Vol 6 (2017)
DNA double-strand breaks (DSBs) and short telomeres are structurally similar, yet they have diametrically opposed fates. Cells must repair DSBs while blocking the action of telomerase on these ends. Short telomeres must avoid recognition by the DNA d
Externí odkaz:
https://doaj.org/article/a96124ee321248c39f9a052bc2141edc
Autor:
Nicole Hustedt, Henrique Melo, Dheva Setiaputra, Jessica Desjardins, Artur Veloso, Rachel K. Szilard, Shou Yun Yin, Alejandro Álvarez-Quilón, Michael Zinda, Timothy F. Ng, Meagan Munro, Robert Papp, Daniel Durocher, Mara De Marco Zompit, Yibo Xue, Giovanni Martino, Jordan T.F. Young, Nathalie Moatti, Salomé Adam, Natasha Chaudhary, Vivek Bhaskaran, Manuel Stucki, Sylvie M. Noordermeer, Toshiro K. Ohsumi, Silvia Emma Rossi
Publikováno v:
Nature Cancer, 2(12), 1357-+. NATURE PORTFOLIO
BRCA1/2-mutated cancer cells adapt to the genome instability caused by their deficiency in homologous recombination (HR). Identification of these adaptive mechanisms may provide therapeutic strategies to target tumors caused by the loss of these gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9275bd317b6ceebb275c11ab3f1a0320
https://doi.org/10.5167/uzh-216678
https://doi.org/10.5167/uzh-216678
Autor:
Yin Sy, Szychowski J, Natasha Chaudhary, Duffy Nm, Veloso A, Bowlan J, Stocco R, Papp R, Martino G, Singhania A, Rachel K. Szilard, Fourtounis J, Leclaire M, Liu B, Alejandro Álvarez-Quilón, de Rugy Tg, Nicolas O, Henrique Melo, Baruah Ps, Hunain Alam, Gary Marshall C, Young Jt, Dietrich E, Gallo D, Desjardins J, Bernier C, Fugère-Desjardins C, Tkáč J, Fournier S, Michael Zinda, Roulston A, Morris Sj, Fortin Ab, Daniel Durocher
Amplification of the gene encoding cyclin E (CCNE1) is an oncogenic driver in several malignancies and is associated with chemoresistance and poor prognosis. To uncover therapeutic targets forCCNE1-amplified tumors, we undertook genome-scale CRISPR/C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::994c0ffdc16dbed0d63dc664ac49d980
https://doi.org/10.1101/2021.04.08.438361
https://doi.org/10.1101/2021.04.08.438361
Autor:
Silvia Emma Rossi, Henrique Melo, Michael Zinda, Veloso A, Bhaskaran, Desjardins J, Zompit Mdm, Timothy F. Ng, Papp R, Salomé Adam, Daniel Durocher, Nathalie Moatti, Alejandro Álvarez-Quilón, Sylvie M. Noordermeer, Meagan Munro, Yin Sy, Young Jt, Nicole Hustedt, Natasha Chaudhary, Rachel K. Szilard, Dheva Setiaputra, Martino G, Manuel Stucki, Ohsumi Tk
BRCA1/2-mutated cancer cells must adapt to the genome instability caused by their deficiency in homologous recombination. Identifying and targeting these adaptive mechanisms may provide new therapeutic strategies. Here we present the results of genom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::74faea63b60db263e7506b7972da4eb1
https://doi.org/10.1101/2021.02.08.430060
https://doi.org/10.1101/2021.02.08.430060
Autor:
Leo C. K. Wan, Samara Mishelle Ona, Pierre Maisonneuve, Derek F. Ceccarelli, Morgan F. Khan, Frank Sicheri, Mark A. Bayfield, Zhe Yin, Dheva Setiaputra, Rachel K. Szilard, Stephen Orlicky, Daniel Y.L. Mao, Jennifer Porat, Jonah Beenstock, Daniel Durocher, David C. Schriemer, Shaunak Raval
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
The KEOPS complex, which is conserved across archaea and eukaryotes, is composed of four core subunits; Pcc1, Kae1, Bud32 and Cgi121. KEOPS is crucial for the fitness of all organisms examined. In humans, pathogenic mutations in KEOPS genes lead to G
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76cf6addae4f930d07dd63677317ea9c
http://europepmc.org/articles/PMC7718258
http://europepmc.org/articles/PMC7718258
Autor:
David Ng, Graham M Pitcher, Rachel K Szilard, Andréa Sertié, Marijana Kanisek, Steven J Clapcote, Tatiana Lipina, Lorraine V Kalia, Daisy Joo, Colin McKerlie, Miguel Cortez, John C Roder, Michael W Salter, Roderick R McInnes
Publikováno v:
PLoS Biology, Vol 7, Iss 2, p e41 (2009)
The N-methyl-D-aspartate receptor (NMDAR), a major excitatory ligand-gated ion channel in the central nervous system (CNS), is a principal mediator of synaptic plasticity. Here we report that neuropilin tolloid-like 1 (Neto1), a complement C1r/C1s, U
Externí odkaz:
https://doaj.org/article/3b93d0508888458dabaff426a1a4130a
Autor:
Pamela Kanellis, Mark Gagliardi, Judit P Banath, Rachel K Szilard, Shinichiro Nakada, Sarah Galicia, Frederic D Sweeney, Diane C Cabelof, Peggy L Olive, Daniel Durocher
Publikováno v:
PLoS Genetics, Vol 3, Iss 8, p e134 (2007)
Genome instability is a hallmark of cancer cells. One class of genome aberrations prevalent in tumor cells is termed gross chromosomal rearrangements (GCRs). GCRs comprise chromosome translocations, amplifications, inversions, deletion of whole chrom
Externí odkaz:
https://doaj.org/article/543d1111c50c4b1cac209eefebc8af72
Autor:
Rachel K. Szilard, Hao Huang, Timothy F. Ng, Amy A. Caudy, Frank Sicheri, Anne-Claude Gingras, Pierre Maisonneuve, Rob C. Laister, Leo C. K. Wan, Jean-Philippe Lambert, Noah Manczyk, Daniel Durocher
Publikováno v:
Nucleic Acids Research
The KEOPS/EKC complex is a tRNA modification complex involved in the biosynthesis of N6-threonylcarbamoyladenosine (t6A), a universally conserved tRNA modification found on ANN-codon recognizing tRNAs. In archaea and eukaryotes, KEOPS is composed of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a69df29f532ae98ea865ddbff1c2a2e
https://doi.org/10.1093/nar/gkw1181
https://doi.org/10.1093/nar/gkw1181