Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Rachel J. Roth Flach"'
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 11 (2024)
The lymphatic vascular system spans nearly every organ in the body and serves as an important network that maintains fluid, metabolite, and immune cell homeostasis. Recently, there has been a growing interest in the role of lymphatic biology in chron
Externí odkaz:
https://doaj.org/article/fb9ea4c13e854ae6b023876d4a91122a
Autor:
Rachel J. Roth Flach, Eliza Bollinger, Allan R. Reyes, Brigitte Laforest, Bethany L. Kormos, Shenping Liu, Matthew R. Reese, Luis A. Martinez Alsina, Leanne Buzon, Yuan Zhang, Bruce Bechle, Amy Rosado, Parag V. Sahasrabudhe, John Knafels, Samit K. Bhattacharya, Kiyoyuki Omoto, John C. Stansfield, Liam D. Hurley, LouJin Song, Lina Luo, Susanne B. Breitkopf, Mara Monetti, Teresa Cunio, Brendan Tierney, Frank J. Geoly, Jake Delmore, C. Parker Siddall, Liang Xue, Ka N. Yip, Amit S. Kalgutkar, Russell A. Miller, Bei B. Zhang, Kevin J. Filipski
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Branched chain amino acid (BCAA) catabolic impairments have been implicated in several diseases. Branched chain ketoacid dehydrogenase (BCKDH) controls the rate limiting step in BCAA degradation, the activity of which is inhibited by BCKDH k
Externí odkaz:
https://doaj.org/article/f9d9823491ce46a3808353f3a122b4ab
Autor:
Eliza Bollinger, Matthew Peloquin, Jenna Libera, Bina Albuquerque, Evanthia Pashos, Arun Shipstone, Angela Hadjipanayis, Zhongyuan Sun, Gang Xing, Michelle Clasquin, John C. Stansfield, Brendan Tierney, Steven Gernhardt, C. Parker Siddall, Timothy Greizer, Frank J. Geoly, Sarah R. Vargas, Lily C. Gao, George Williams, Mackenzie Marshall, Amy Rosado, Claire Steppan, Kevin J. Filipski, Bei B. Zhang, Russell A. Miller, Rachel J. Roth Flach
Publikováno v:
Molecular Metabolism, Vol 66, Iss , Pp 101611- (2022)
Objective: Branched chain amino acid (BCAA) catabolic defects are implicated to be causal determinates of multiple diseases. This work aimed to better understand how enhancing BCAA catabolism affected metabolic homeostasis as well as the mechanisms u
Externí odkaz:
https://doaj.org/article/e41f6bdec3ce4e71ab9ff32d257eaba6
Autor:
Marina T. DiStefano, Rachel J. Roth Flach, Ozlem Senol-Cosar, Laura V. Danai, Joseph V. Virbasius, Sarah M. Nicoloro, Juerg Straubhaar, Sezin Dagdeviren, Martin Wabitsch, Olga T. Gupta, Jason K. Kim, Michael P. Czech
Publikováno v:
Molecular Metabolism, Vol 5, Iss 12, Pp 1149-1161 (2016)
Objective: Adipose tissue relies on lipid droplet (LD) proteins in its role as a lipid-storing endocrine organ that controls whole body metabolism. Hypoxia-inducible Gene 2 (Hig2) is a recently identified LD-associated protein in hepatocytes that pro
Externí odkaz:
https://doaj.org/article/da5c0d463454410a9f92bd4386dce998
Autor:
Ozlem Senol-Cosar, Rachel J. Roth Flach, Marina DiStefano, Anil Chawla, Sarah Nicoloro, Juerg Straubhaar, Olga T. Hardy, Hye Lim Noh, Jason K. Kim, Martin Wabitsch, Philipp E. Scherer, Michael P. Czech
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Expansion of visceral adipose tissue is usually associated with insulin resistance and metabolic disease. Here, the authors show that the membrane protein TNMD is upregulated in visceral fat of insulin resistant obese individuals and promotes healthy
Externí odkaz:
https://doaj.org/article/2b8301dcb67b41eabe00ec0fa2a01c48
Autor:
Megan C. Blair, Michael D. Neinast, Cholsoon Jang, Qingwei Chu, Jae Woo Jung, Jessie Axsom, Marc R. Bornstein, Chelsea Thorsheim, Kristina Li, Atsushi Hoshino, Steven Yang, Rachel J. Roth Flach, Bei B. Zhang, Joshua D. Rabinowitz, Zoltan Arany
Publikováno v:
Nature Metabolism. 5:589-606
Autor:
Michael Y. Mi, Mark Whitlock, Xu Shi, Laurie A. Farrell, Victoria M. Bhambhani, Juweria Quadir, Matthew Blatnik, Kyle P. Wald, Brendan Tierney, Albert Kim, Peter Loudon, Zsu-Zsu Chen, Adolfo Correa, Yan Gao, April P. Carson, Alain G. Bertoni, Rachel J. Roth Flach, Robert E. Gerszten
Publikováno v:
The American Journal of Clinical Nutrition. 117:529-539
Autor:
Jia-yu Yu, Nancy Cao, Christoph D. Rau, Ro-Po Lee, Jieping Yang, Rachel J. Roth Flach, Lauren Petersen, Cansheng Zhu, Yea-Lyn Pak, Russell A. Miller, Yunxia Liu, Yibin Wang, Zhaoping Li, Haipeng Sun, Chen Gao
Publikováno v:
Acta Pharmacologica Sinica.
Parallel to major changes in fatty acid and glucose metabolism, defect in branched-chain amino acid (BCAA) catabolism has also been recognized as a metabolic hallmark and potential therapeutic target for heart failure. However, BCAA catabolic enzymes
Autor:
Xian Chen, Eliza Bollinger, Teresa Cunio, Federico Damilano, John C. Stansfield, Cynthia A. Pinkus, Steven Kreuser, Dinesh Hirenallur-Shanthappa, Rachel J. Roth Flach
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 322:H234-H245
Mouse models are used to model human diseases and perform pharmacological efficacy testing to advance therapies to humans; most of these studies are conducted in room temperature conditions. At room temperature (22°C), mice are cold-stressed and mus
Autor:
Shenping Liu, Bethany L. Kormos, John D. Knafels, Parag V. Sahasrabudhe, Amy Rosado, Ruth F. Sommese, Allan R. Reyes, Jessica Ward, Rachel J. Roth Flach, Xiaochun Wang, Leanne M. Buzon, Matthew R. Reese, Samit K. Bhattacharya, Kiyoyuki Omoto, Kevin J. Filipski
Publikováno v:
Journal of Biological Chemistry. 299:102959