Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Rachel J Roth Flach"'
Autor:
LouJin Song, Xian Chen, Terri A Swanson, Brianna LaViolette, Jincheng Pang, Teresa Cunio, Michael W Nagle, Shoh Asano, Katherine Hales, Arun Shipstone, Hanna Sobon, Sabra D Al-Harthy, Youngwook Ahn, Steven Kreuser, Andrew Robertson, Casey Ritenour, Frank Voigt, Magalie Boucher, Furong Sun, William C Sessa, Rachel J Roth Flach
Publikováno v:
eLife, Vol 9 (2020)
The lymphatic vasculature is involved in the pathogenesis of acute cardiac injuries, but little is known about its role in chronic cardiac dysfunction. Here, we demonstrate that angiotensin II infusion induced cardiac inflammation and fibrosis at 1 w
Externí odkaz:
https://doaj.org/article/cffe82a9df6a402a999f6d3b68cbed94
Autor:
Rachel J Roth Flach, Chunyan Su, Eliza Bollinger, Christian Cortes, Andrew W Robertson, Alan C Opsahl, Timothy M Coskran, Kevin P Maresca, Edmund J Keliher, Phillip D Yates, Albert M Kim, Amit S Kalgutkar, Leonard Buckbinder
Publikováno v:
PLoS ONE, Vol 14, Iss 3, p e0214150 (2019)
Myeloperoxidase (MPO) is a highly abundant protein within the neutrophil that is associated with lipoprotein oxidation, and increased plasma MPO levels are correlated with poor prognosis after myocardial infarct. Thus, MPO inhibitors have been develo
Externí odkaz:
https://doaj.org/article/1d4d82c1feff4fad91bb96d03ddfbae9
Autor:
Kimberly A Negrin, Rachel J Roth Flach, Marina T DiStefano, Anouch Matevossian, Randall H Friedline, DaeYoung Jung, Jason K Kim, Michael P Czech
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e107265 (2014)
Non-alcoholic fatty liver disease is prevalent in human obesity and type 2 diabetes, and is characterized by increases in both hepatic triglyceride accumulation (denoted as steatosis) and expression of pro-inflammatory cytokines such as IL-1β. We re
Externí odkaz:
https://doaj.org/article/66320ee6e11440dabb45ca7cea33b6bf
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 11 (2024)
The lymphatic vascular system spans nearly every organ in the body and serves as an important network that maintains fluid, metabolite, and immune cell homeostasis. Recently, there has been a growing interest in the role of lymphatic biology in chron
Externí odkaz:
https://doaj.org/article/fb9ea4c13e854ae6b023876d4a91122a
Autor:
Rachel J. Roth Flach, Eliza Bollinger, Allan R. Reyes, Brigitte Laforest, Bethany L. Kormos, Shenping Liu, Matthew R. Reese, Luis A. Martinez Alsina, Leanne Buzon, Yuan Zhang, Bruce Bechle, Amy Rosado, Parag V. Sahasrabudhe, John Knafels, Samit K. Bhattacharya, Kiyoyuki Omoto, John C. Stansfield, Liam D. Hurley, LouJin Song, Lina Luo, Susanne B. Breitkopf, Mara Monetti, Teresa Cunio, Brendan Tierney, Frank J. Geoly, Jake Delmore, C. Parker Siddall, Liang Xue, Ka N. Yip, Amit S. Kalgutkar, Russell A. Miller, Bei B. Zhang, Kevin J. Filipski
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Branched chain amino acid (BCAA) catabolic impairments have been implicated in several diseases. Branched chain ketoacid dehydrogenase (BCKDH) controls the rate limiting step in BCAA degradation, the activity of which is inhibited by BCKDH k
Externí odkaz:
https://doaj.org/article/f9d9823491ce46a3808353f3a122b4ab
Autor:
Megan C. Blair, Michael D. Neinast, Cholsoon Jang, Qingwei Chu, Jae Woo Jung, Jessie Axsom, Marc R. Bornstein, Chelsea Thorsheim, Kristina Li, Atsushi Hoshino, Steven Yang, Rachel J. Roth Flach, Bei B. Zhang, Joshua D. Rabinowitz, Zoltan Arany
Publikováno v:
Nature Metabolism. 5:589-606
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6262b07e528909e5110666cf8a4b8046
https://doi.org/10.1038/s42255-023-00794-y
https://doi.org/10.1038/s42255-023-00794-y
Autor:
Michael Y. Mi, Mark Whitlock, Xu Shi, Laurie A. Farrell, Victoria M. Bhambhani, Juweria Quadir, Matthew Blatnik, Kyle P. Wald, Brendan Tierney, Albert Kim, Peter Loudon, Zsu-Zsu Chen, Adolfo Correa, Yan Gao, April P. Carson, Alain G. Bertoni, Rachel J. Roth Flach, Robert E. Gerszten
Publikováno v:
The American Journal of Clinical Nutrition. 117:529-539
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::71db361603581f01b841e09823aea922
https://doi.org/10.1016/j.ajcnut.2023.01.001
https://doi.org/10.1016/j.ajcnut.2023.01.001
Autor:
Jia-yu Yu, Nancy Cao, Christoph D. Rau, Ro-Po Lee, Jieping Yang, Rachel J. Roth Flach, Lauren Petersen, Cansheng Zhu, Yea-Lyn Pak, Russell A. Miller, Yunxia Liu, Yibin Wang, Zhaoping Li, Haipeng Sun, Chen Gao
Publikováno v:
Acta Pharmacologica Sinica.
Parallel to major changes in fatty acid and glucose metabolism, defect in branched-chain amino acid (BCAA) catabolism has also been recognized as a metabolic hallmark and potential therapeutic target for heart failure. However, BCAA catabolic enzymes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::38f913ee50680ddf2a89f4ced45aa160
https://doi.org/10.1038/s41401-023-01076-9
https://doi.org/10.1038/s41401-023-01076-9
Autor:
Xian Chen, Eliza Bollinger, Teresa Cunio, Federico Damilano, John C. Stansfield, Cynthia A. Pinkus, Steven Kreuser, Dinesh Hirenallur-Shanthappa, Rachel J. Roth Flach
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 322:H234-H245
Mouse models are used to model human diseases and perform pharmacological efficacy testing to advance therapies to humans; most of these studies are conducted in room temperature conditions. At room temperature (22°C), mice are cold-stressed and mus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4ee1d3337c3b3a49d6e00ad4a59f5e1
https://doi.org/10.1152/ajpheart.00461.2021
https://doi.org/10.1152/ajpheart.00461.2021
Autor:
Eliza Bollinger, Matthew Peloquin, Jenna Libera, Bina Albuquerque, Evanthia Pashos, Arun Shipstone, Angela Hadjipanayis, Zhongyuan Sun, Gang Xing, Michelle Clasquin, John C. Stansfield, Brendan Tierney, Steven Gernhardt, C. Parker Siddall, Timothy Greizer, Frank J. Geoly, Sarah R. Vargas, Lily C. Gao, George Williams, Mackenzie Marshall, Amy Rosado, Claire Steppan, Kevin J. Filipski, Bei B. Zhang, Russell A. Miller, Rachel J. Roth Flach
Publikováno v:
Molecular metabolism. 66
Branched chain amino acid (BCAA) catabolic defects are implicated to be causal determinates of multiple diseases. This work aimed to better understand how enhancing BCAA catabolism affected metabolic homeostasis as well as the mechanisms underlying t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfc89625928d542a48371e13fb76c6b7
https://pubmed.ncbi.nlm.nih.gov/36220546
https://pubmed.ncbi.nlm.nih.gov/36220546