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Autor:
Jeremy S. Parker, Michael P. Housden, Ian Paterson, Nelson Y. S. Lam, Jason S. Carroll, Stephen J. Walsh, David R. Spring, Talia R Pettigrew, Rachel J Porter
Publikováno v:
Chemical communications (Cambridge, England). 56(10)
The aplyronines are a family of highly cytotoxic marine natural products with potential application in targeted cancer chemotherapy. To address the severe supply issue, function-oriented molecular editing of their macrolactone scaffold led to the des