Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Rachel J Mitchell"'
Autor:
David I Marks, Amy A Kirkwood, Clare J Rowntree, Melanie Aguiar, Katharine E Bailey, Brendan Beaton, Paul Cahalin, Anna Z Castleton, Laura Clifton-Hadley, Mhairi Copland, Anthony H Goldstone, Richard Kelly, Emma Lawrie, SooWah Lee, Andrew K McMillan, Mary Frances McMullin, Tobias F Menne, Rachel J Mitchell, Anthony V Moorman, Bela Patel, Pip Patrick, Paul Smith, David Taussig, Deborah Yallop, Krisztina Zuborne Alapi, Adele K Fielding
Publikováno v:
Marks, D I, Kirkwood, A A, Rowntree, C J, Aguiar, M, Bailey, K E, Beaton, B, Cahalin, P, Castleton, A Z, Clifton-Hadley, L, Copland, M, Goldstone, A H, Kelly, R, Lawrie, E, Lee, S, McMillan, A K, McMullin, M F, Menne, T F, Mitchell, R J, Moorman, A V, Patel, B, Patrick, P, Smith, P, Taussig, D, Yallop, D, Alapi, K Z & Fielding, A K 2022, ' Addition of four doses of rituximab to standard induction chemotherapy in adult patients with precursor B-cell acute lymphoblastic leukaemia (UKALL14): a phase 3, multicentre, randomised controlled trial ', The Lancet Haematology, vol. 9, no. 4, pp. e262-e275 . https://doi.org/10.1016/S2352-3026(22)00038-2
BACKGROUND: Treatment for adults with acute lymphoblastic leukaemia requires improvement. UKALL14 was a UK National Cancer Research Institute Adult ALL group study that aimed to determine the benefit of adding the anti-CD20 monoclonal antibody, ritux
Autor:
Pip Patrick, Clare J. Rowntree, Andrew McMillan, Emma Lawrie, Krisztina Zuborne Alapi, Bela Patel, Laura Clifton-Hadley, Emilio Barretta, Adele K. Fielding, Rachel J. Mitchell, Anthony V. Moorman, Tobias F. Menne, Elli Papaemmanuil, David I. Marks, Soo Wah Lee, Amy A Kirkwood, Daniel Leongamornlert, Nahid Zareian
Publikováno v:
Blood Adv
IKZF1 deletions (ΔIKZF1) are commonly detected in B-precursor acute lymphoblastic leukemia (ALL; B-ALL) and are widely assumed to have a significant impact on outcome. We compared the ability of multiplex ligand-dependent probe amplification (MLPA)
Autor:
Sarah Aref, Daniel Leongamornlert, Richard K. Burt, Adele K. Fielding, Dina Ahmed Said Aly Okasha, Aditi Dey, Katharine Bailey, Anna Castleton, Rachel J. Mitchell
Publikováno v:
Mol Ther
The mechanism of tumor-selective replication of oncolytic measles virus (MV) is poorly understood. Using a stepwise model of cellular transformation, in which oncogenic hits were additively expressed in human bone marrow-derived mesenchymal stromal c
Autor:
Jesus Gutierrez-Abril, Laura Clifton-Hadley, Anthony V. Moorman, Neerav Shukla, Yangyu Zhou, SooWah Lee, Amy A Kirkwood, Gunes Gundem, Pip Patrick, Juan E. Arango Ossa, Adele K. Fielding, Maria Luisa Sulis, Juan S. Medina-Martinez, Elli Papaemmanuil, Andrew L. Kung, Daniel Leongamornlert, Rachel J. Mitchell, Max Levine, Bela Wrench
Publikováno v:
Journal of Clinical Oncology. 39:7028-7028
7028 Background: Hematological neoplasms are often characterized by acute onset and rapid disease progression. Cytogenetics, FISH, SNP arrays, targeted DNA and RNA sequencing are performed to inform diagnosis, risk stratification and guide treatment
Autor:
Erik Sahai, Krisztina Zuborne-Alapi, Jiten Manji, Amy A Kirkwood, Sarah Aref, Constandina Pospori, Adele K. Fielding, William Day, Ayse U. Akarca, SooWah Lee, Marc R. Mansour, I Puccio, Rachel J. Mitchell, Aditi Dey, Robert C. Muirhead, Katharine Bailey, Teresa Marafioti, Melanie Aguiar, Kristina Kirschner, Steven Hooper, Richard K. Burt, Kenton Cheuk Yan Ng, Cristina Lo Celso
We investigated and modeled the mesenchymal stromal cell (MSC) niche in adult acute lymphoblastic leukemia (ALL). We used gene expression profiling, cytokine/chemokine quantification, flow cytometry, and a variety of imaging techniques to show that M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06d45c01fc617a63a81138a5ad83f72d
https://europepmc.org/articles/PMC6856969/
https://europepmc.org/articles/PMC6856969/
Autor:
Juan L Garcia-Leon, Elizabeth Cervantes, Cesar Samanez-Figari, Krisztina Zuborne Alapi, Jhoysi Casas, Arturo Zapata, Rachel J. Mitchell, Daniel J Enriquez, Karina Cancino, Gustavo Sandival, Adele K. Fielding, Juan C Haro, Bryan Valcarcel
Publikováno v:
Blood. 136:11-11
Frequency of IKZF1 Deletions in a Peruvian Population with B-cell Acute Lymphoblastic Leukemia Background: B-cell Acute Lymphoblastic Leukemia (B-ALL) is an aggressive disease with worse outcomes in older patients, and latino ethnicity. Additionally,
Autor:
Thomas Creasey, Amy A Kirkwood, Emilio Barretta, Daniel Leongamornlert, Elli Papaemmanuil, Adele K. Fielding, Soo Wah Lee, Anthony V. Moorman, Rachel J. Mitchell, Bela Wrench, Pip Patrick, Laura Clifton-Hadley, Peter J. Campbell
Publikováno v:
Blood. 134:2743-2743
B-other ALL represents a working definition for patients with B cell precursor (BCP) ALL without a known primary chromosomal abnormality. In this study we use whole genome sequencing (WGS) to characterize adult B-other cases (age ≥ 25yrs) from the
Autor:
Clare Rowntree, Paul Smith, Pip Patrick, Laura Clifton-Hadley, Rachel J. Mitchell, Bela Wrench, David I. Marks, Amy A Kirkwood, Krisztina Zuborne Alapi, Brendan Beaton, Melanie Aguiar, Tobias Menne, Anthony V. Moorman, Andrew McMillan, Katharine Bailey, Adele K. Fielding, SooWah Lee, Emma Lawrie
Publikováno v:
Blood. 134:739-739
UKALL14 (NCT01085617) randomised 655 patients aged 25-65 years with B-precursor ALL, irrespective of Philadelphia chromosome (Ph) status or cell surface CD20 expression to determine if the addition of four doses of rituximab to standard induction che
Autor:
Marc R. Mansour, Nadine Farah, Teodora Popa, Sunniyat Rahman, Rachel J. Mitchell, Richard A. Young, Rosemary E. Gale, Christopher Allen, Sophia Bustraan, David C. Linch, Arnold Pizzey, Michael Magnussen, Frank J. T. Staal, Tom Naughton, Brian J. Abraham, Karin Pike-Overzet, Laura Garcia-Perez, Zhaodong Li, Krisztina Zuborne Alapi, A. Thomas Look, Theresa E. Leon, Adele K. Fielding
Publikováno v:
Blood, 129(24), 3221-3226
Prof. Young
Prof. Young
Somatic mutations within noncoding genomic regions that aberrantly activate oncogenes have remained poorly characterized. Here we describe recurrent activating intronic mutations of LMO2, a prominent oncogene in T-cell acute lymphoblastic leukemia (T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::974dc70bbf3a822f4cc2f9610040c273
http://hdl.handle.net/1887/116028
http://hdl.handle.net/1887/116028
Autor:
Krisztina Zuborne Alapi, Tom Naughton, Theresa E. Leon, Brian J. Abraham, Christopher Allen, Michael Magnussen, Zhaodong Li, Richard A. Young, Rosemary E. Gale, Adele K. Fielding, A. Thomas Look, Nadine Farah, Sunniyat Rahman, Marc R. Mansour, Sophia Bustraan, David C. Linch, Arnold Pizzey, Rachel J. Mitchell
Publikováno v:
Blood. 128:733-733
LMO2is a crucial regulator of normal hematopoiesis but is progressively silenced from the early T-cell progenitor stage of thymic development. Aberrant LMO2 expression leads to a block in differentiation, increased self-renewal and aggressive T-cell