Activated but functionally impaired memory Tregs are expanded in slow progressors to type 1 diabetes

Autor: Clare Megson, Anna E. Long, Isabel V. Wilson, F. Susan Wong, Rachel J Aitken, Stephanie J. Hanna, Kathleen M Gillespie, Joanne Boldison

Publikováno v: Diabetologia
Boldison, J, Long, A E, Aitken, R J, Wilson, I V, Hanna, S, Wong, F S & Gillespie, K M 2022, ' Activated but functionally impaired memory Tregs are expanded in slow progressors to type 1 diabetes ', Diabetologia, vol. 65, no. 2, pp. 343-355 . https://doi.org/10.1007/s00125-021-05595-0

Aims/hypothesis Slow progressors to type 1 diabetes are individuals positive for multiple pancreatic islet autoantibodies who have remained diabetes-free for at least 10 years; regulation of the autoimmune response is understudied in this group. Here

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::460b8482e2433313b173be3da48524a8
http://europepmc.org/articles/PMC8741669

Beta cell function and ongoing autoimmunity in long-standing, childhood onset type 1 diabetes

Autor: Rachel J Aitken, Rebecca Wyatt, Isabel V. Wilson, Polly J. Bingley, Georgina M Williams, F. Susan Wong, Alistair J K Williams, Anna E. Long, Andrew T. Hattersley, Timothy J. McDonald, Kathleen M Gillespie

Publikováno v: Diabetologia
Williams, G, Long, A, Wilson, I, Aitken, R, Wyatt, R, McDonald, T J, Wong, S, Hattersley, A T, Williams, A, Bingley, P & Gillespie, K 2016, ' Beta cell function and ongoing autoimmunity in long-standing, childhood onset type 1 diabetes. ', Diabetologia, vol. 59, no. 12, pp. 2722-2726 . https://doi.org/10.1007/s00125-016-4087-0

Aims/hypothesis This study aimed to determine the frequency\ud of residual beta cell function in individuals with long-standing\ud type 1 diabetes who were recruited at diagnosis, and relate this\ud to baseline and current islet autoantibody profile.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12ca02d0ba14012ef14c1416b2cb8354
https://orca.cardiff.ac.uk/id/eprint/96318/1/WilliamsGillespieDiabetologia2016.pdf

Type 1 Diabetes High-Risk HLA Class II Determination by Polymerase Chain Reaction Sequence-Specific Primers

Autor: Rachel J, Aitken, Georgina L, Mortimer, Kathleen M, Gillespie

Publikováno v: Methods in molecular biology (Clifton, N.J.). 1433

The only strategy to select individuals at increased risk for type 1 diabetes for primary prevention trials is through genetic risk assessment. While genome-wide association studies have identified more than 40 loci associated with type 1 diabetes, t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2ca0b8aeca1f16f3630d3771d4192e5b
https://pubmed.ncbi.nlm.nih.gov/26659794

Type 1 Diabetes High-Risk HLA Class II Determination by Polymerase Chain Reaction Sequence-Specific Primers

Autor: Rachel J Aitken, Georgina L. Mortimer, Kathleen M Gillespie

Publikováno v: Methods in Molecular Biology ISBN: 9781493936410

The only strategy to select individuals at increased risk for type 1 diabetes for primary prevention trials is through genetic risk assessment. While genome-wide association studies have identified more than 40 loci associated with type 1 diabetes, t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f13a57fee93abad4fd88c74c5adde26d
https://doi.org/10.1007/7651_2015_307

Early-Onset, Coexisting Autoimmunity and Decreased HLA-Mediated Susceptibility Are the Characteristics of Diabetes in Down Syndrome

Autor: Tilman R. Rohrer, Kathleen M Gillespie, Jamie Brown, Julian P.H. Shield, Alistair J K Williams, Edith Schober, Reinhard W. Holl, Kay L. Mehers, Rachel J Aitken, Majedah M. Abdul-Rasoul, Polly J. Bingley

Publikováno v: Aitken, R J, Mehers, K L, Williams, A J K, Brown, J L, Bingley, P J, Holl, R W, Rohrer, T P, Schober, E, Abdul-Rasoul, M M, Hamilton-Shield, J P & Gillespie, K M 2013, ' Early-Onset, Coexisting Autoimmunity and Decreased HLA-Mediated Susceptibility Are the Characteristics of Diabetes in Down Syndrome ', Diabetes Care, vol. 36, no. 5, pp. 1181-1185 . https://doi.org/10.2337/dc12-1712
Diabetes Care

OBJECTIVE Down syndrome (DS) is associated with an increased risk of diabetes, particularly in young children. HLA-mediated risk is however decreased in children with DS and diabetes (DSD). We hypothesized that early-onset diabetes in children with D

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3a26f05ab5878f3f782c76533823382
https://research-information.bris.ac.uk/en/publications/b2ee7b1f-ba79-4e07-8b96-aba4265c55e3