Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Rachel J, Lew"'
Autor:
I-Li Tan, Alexendar R. Perez, Rachel J. Lew, Xiaoyu Sun, Alisha Baldwin, Yong K. Zhu, Mihir M. Shah, Mitchel S. Berger, Jennifer A. Doudna, Christof Fellmann
Publikováno v:
Cell Reports, Vol 42, Iss 11, Pp 113339- (2023)
Summary: Glioblastoma (GBM) is the most common lethal primary brain cancer in adults. Despite treatment regimens including surgical resection, radiotherapy, and temozolomide (TMZ) chemotherapy, growth of residual tumor leads to therapy resistance and
Externí odkaz:
https://doaj.org/article/d8685e6afe054325880742901e6d843a
Autor:
Marco J. Lobba, Christof Fellmann, Alan M. Marmelstein, Johnathan C. Maza, Elijah N. Kissman, Stephanie A. Robinson, Brett T. Staahl, Cole Urnes, Rachel J. Lew, Casey S. Mogilevsky, Jennifer A. Doudna, Matthew B. Francis
Publikováno v:
ACS Central Science, Vol 6, Iss 9, Pp 1564-1571 (2020)
Externí odkaz:
https://doaj.org/article/717bb74132f54986ad0e5c0d11e24c37
Autor:
Mandy Y. Boontanrart, Markus S. Schröder, Gautier M. Stehli, Marija Banović, Stacia K. Wyman, Rachel J. Lew, Matteo Bordi, Benjamin G. Gowen, Mark A. DeWitt, Jacob E. Corn
Publikováno v:
Cell Reports, Vol 32, Iss 5, Pp 107993- (2020)
Summary: β-Hemoglobinopathies can trigger rapid production of red blood cells in a process known as stress erythropoiesis. Cellular stress prompts differentiating erythroid precursors to express high levels of fetal γ-globin. However, the mechanism
Externí odkaz:
https://doaj.org/article/3fe47469212244e8974cbf8b70ce5d59
Autor:
Gavin J Knott, Brady F Cress, Jun-Jie Liu, Brittney W Thornton, Rachel J Lew, Basem Al-Shayeb, Daniel J Rosenberg, Michal Hammel, Benjamin A Adler, Marco J Lobba, Michael Xu, Adam P Arkin, Christof Fellmann, Jennifer A Doudna
Publikováno v:
eLife, Vol 8 (2019)
CRISPR-Cas systems provide bacteria and archaea with programmable immunity against mobile genetic elements. Evolutionary pressure by CRISPR-Cas has driven bacteriophage to evolve small protein inhibitors, anti-CRISPRs (Acrs), that block Cas enzyme fu
Externí odkaz:
https://doaj.org/article/164dc30ebd294804bf4e661f484ab735
Autor:
Rachel J. Lew, Christof Fellmann, Thomas G. Laughlin, Arik Shams, Benjamin L. Oakes, Maria Lukarska, David F. Savage, Jennifer A. Doudna, Brett T. Staahl, Shin Kim, Sean Higgins, Madeline L. Arnold
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Nature Communications
Nature Communications
Proteins evolve through the modular rearrangement of elements known as domains. Extant, multidomain proteins are hypothesized to be the result of domain accretion, but there has been limited experimental validation of this idea. Here, we introduce a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4f70d441a833ddfbd416ccca873bb39
https://doaj.org/article/f92b1a4bf0574fe9b95344d8bcec8e40
https://doaj.org/article/f92b1a4bf0574fe9b95344d8bcec8e40
Autor:
Matthew B. Francis, Alan M. Marmelstein, Brett T. Staahl, Johnathan C. Maza, Stephanie A. Robinson, Elijah N Kissman, Marco J. Lobba, Casey S. Mogilevsky, Rachel J. Lew, Jennifer A. Doudna, Christof Fellmann, Cole Urnes
Publikováno v:
ACS Central Science, Vol 6, Iss 9, Pp 1564-1571 (2020)
ACS Central Science
ACS Central Science
The synthesis of protein–protein and protein–peptide conjugates is an important capability for producing vaccines, immunotherapeutics, and targeted delivery agents. Herein we show that the enzyme tyrosinase is capable of oxidizing exposed tyrosin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4600a77b0411205dee1e9f3902acd10d
https://doaj.org/article/717bb74132f54986ad0e5c0d11e24c37
https://doaj.org/article/717bb74132f54986ad0e5c0d11e24c37
Autor:
Blake McMahon, Rachel J. Lew, Jennifer A. Doudna, Haridha Shivram, Christof Fellmann, Kyle E. Watters
Publikováno v:
Proceedings of the National Academy of Sciences. 117:6531-6539
Anti-CRISPRs (Acrs) are small proteins that inhibit the RNA-guided DNA targeting activity of CRISPR-Cas enzymes. Encoded by bacteriophage and phage-derived bacterial genes, Acrs prevent CRISPR-mediated inhibition of phage infection and can also block
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::02928fcd83c577605f2dc03af40a6acf
https://doi.org/10.1073/pnas.1917668117
https://doi.org/10.1073/pnas.1917668117
Autor:
Enrique Lin-Shiao, Wolfgang G Pfeifer, Brian R Shy, Mohammad Saffari Doost, Evelyn Chen, Vivasvan S Vykunta, Jennifer R Hamilton, Elizabeth C Stahl, Diana M Lopez, Cindy R Sandoval Espinoza, Alexander E Deyanov, Rachel J Lew, Michael G Poirer, Alexander Marson, Carlos E Castro, Jennifer A Doudna
Publikováno v:
Nucleic acids research. 50(3)
DNA nanostructures are a promising tool to deliver molecular payloads to cells. DNA origami structures, where long single-stranded DNA is folded into a compact nanostructure, present an attractive approach to package genes; however, effective deliver
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a432c1ed1e4a4adbc1fb7078ee0e1aac
https://pubmed.ncbi.nlm.nih.gov/35104875
https://pubmed.ncbi.nlm.nih.gov/35104875
Autor:
Alexandra M. Amen, Ryan M. Loughran, Chun-Hao Huang, Rachel J. Lew, Archna Ravi, Yuanzhe Guan, Emma M. Schatoff, Lukas E. Dow, Brooke M. Emerling, Christof Fellmann
Publikováno v:
Cell reports methods, vol 2, iss 7
We present Multi-miR, a microRNA-embedded shRNA system modeled after endogenous microRNA clusters that enables simultaneous expression of up to three or four short hairpin RNAs (shRNAs) from a single promoter without loss of activity, enabling robust
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6908663862a8a6e6457494cbe28cb5ea
https://pubmed.ncbi.nlm.nih.gov/35880017
https://pubmed.ncbi.nlm.nih.gov/35880017
Autor:
Jennifer R. Hamilton, Diana M. Lopez, Cindy R. Sandoval Espinoza, Alexander E. Dejanov, Michael G. Poirer, Vivasvan Vykunta, Rachel J. Lew, Enrique Lin-Shiao, Carlos E. Castro, Brian R. Shy, Alexander Marson, Mohammad Saffari Doost, Wolfgang Pfeifer, Jennifer A. Doudna, Evelyn Chen, Elizabeth C. Stahl
DNA nanostructures are a promising tool for delivery of a variety of molecular payloads to cells. DNA origami structures, where 1000’s of bases are folded into a compact nanostructure, present an attractive approach to package genes; however, effec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::de2d8888b97cc7c800b8ac0999c0148d
https://doi.org/10.1101/2021.11.08.467750
https://doi.org/10.1101/2021.11.08.467750
