Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Rachel J, Eclov"'
Autor:
Terra E W Lewis, David W Scott, Kirsten B Romero, Rachel J Eclov, Jeremy L Rouse, Daniel D McCoy, Mayank Kapadia, Clayton W Beard, Gary S Mansfield
Publikováno v:
Journal of the Endocrine Society
Severe Congenital Adrenal Hyperplasia (CAH) is most commonly caused by genetic defects in the CYP21A2 gene, which leads to a deficiency of 21-hydroxylase enzyme and disruption in the biosynthesis of Adrenal corticosteriods. Despite treatment with cor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9f5f1d005ca614855e6fe0cdb77cf6e
http://europepmc.org/articles/PMC7209390
http://europepmc.org/articles/PMC7209390
Autor:
Adam J Shaywitz, Sophie Le Fur, Rafael D Escandon, Mimi S. Kim, Rachel J Eclov, Richard J. Auchus, Deborah P. Merke, Mitchell E. Geffner, Clayton W Beard, Pierre Bougnères, Kamal N Bharucha, Kyriakie Sarafoglou
Publikováno v:
Journal of the Endocrine Society. 5:A82-A82
The CYP21A2 gene, which encodes the 21-hydroxylase enzyme, plays a critical role in glucocorticoid (GC) and mineralocorticoid synthesis by the adrenal cortex. CYP21A2 pathogenic variants cause 21-hydroxylase deficiency (21OHD), the most common type o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3dc57926c6033783e8755de07a1f4017
https://doi.org/10.1210/jendso/bvab048.165
https://doi.org/10.1210/jendso/bvab048.165
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 46(5)
ABCG2 encodes the breast cancer resistance protein (BCRP), an efflux membrane transporter important in the detoxification of xenobiotics. In the present study, the basal activity of the ABCG2 promoter in liver, kidney, intestine, and breast cell line
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::29043a217ac99925f9edec88057353f7
https://pubmed.ncbi.nlm.nih.gov/29467213
https://pubmed.ncbi.nlm.nih.gov/29467213
Publikováno v:
Pharmacogenetics and genomics, vol 27, iss 12
Author(s): Eclov, Rachel J; Kim, Mee J; Chhibber, Aparna; Smith, Robin P; Ahituv, Nadav; Kroetz, Deanna L | Abstract: ObjectivesThe expression and activity of the breast cancer resistance protein (ABCG2) contributes toward the pharmacokinetics of end
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::101fc1c78e729eb05e0ff3880923e216
https://pubmed.ncbi.nlm.nih.gov/28930109
https://pubmed.ncbi.nlm.nih.gov/28930109
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 45(2)
ABCG2 encodes the mitoxantrone resistance protein (MXR; breast cancer resistance protein), an ATP-binding cassette (ABC) efflux membrane transporter. Computational analysis of the ∼300 kb region of DNA surrounding ABCG2 (chr4:88911376-89220011, hg1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e97647040cf5f677d95ac1cd443db38a
https://pubmed.ncbi.nlm.nih.gov/27856528
https://pubmed.ncbi.nlm.nih.gov/27856528
Autor:
Deanna L. Kroetz, Eric Jorgenson, Eric P. Winer, Lawrence N. Shulman, Yusuke Nakamura, John S. Witte, Joel Mefford, Howard L. McLeod, Kouros Owzar, Rachel J. Eclov, Mark J. Ratain, Clifford A. Hudis, Chen Jiang, Aparna Chhibber, Hitoshi Zembutsu, R. Michael Baldwin, Paula N. Friedman, Michiaki Kubo, Dorothy Watson
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 18(18)
Purpose: Sensory peripheral neuropathy is a common and sometimes debilitating toxicity associated with paclitaxel therapy. This study aims to identify genetic risk factors for the development of this toxicity. Experimental Design: A prospective pharm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8e218b38e1dd15d5442ef681980940d
https://pubmed.ncbi.nlm.nih.gov/22843789
https://pubmed.ncbi.nlm.nih.gov/22843789