Zobrazeno 1 - 10
of 93
pro vyhledávání: '"Rachel Hargest"'
Autor:
Rocco Friebel, Rachel Hargest, Martilord Ifeanyichi, Taiwo Oladimeji, Jose Luis Mosso Lara, Phyllis Tenkorang, Meskerem Aleka Kebede, Maeve Bognini, Alshaheed Nasraldin Abdelhabeeb, Uchenna Amaechina, Faiza Ambreen, Shreeja Sarabu, Ana Carolina Toguchi
Publikováno v:
BMJ Global Health, Vol 9, Iss 10 (2024)
Background Cost-effectiveness evidence is a critical tool to support resource allocation decisions. There is growing recognition that the development of benefit packages for surgical care should be guided by such evidence, particularly in resource-co
Externí odkaz:
https://doaj.org/article/4113ceda32234d1dbcacd2b018f565df
Identifying critical gaps in research to advance global surgery by 2030: a systematic mapping review
Autor:
Meskerem Aleka Kebede, Deng Simon Garang Tor, Tesfamariam Aklilu, Adane Petros, Martilord Ifeanyichi, Ezekiel Aderaw, Maeve Sophia Bognini, Darshita Singh, Rosemary Emodi, Rachel Hargest, Rocco Friebel
Publikováno v:
BMC Health Services Research, Vol 23, Iss 1, Pp 1-8 (2023)
Abstract Progress on surgical system strengthening has been slow due to a disconnect between evidence generation and the information required for effective policymaking. This systematic mapping review sought to assess critical research gaps in the fi
Externí odkaz:
https://doaj.org/article/44eb0d10a8444954a0517eab6a1ad65d
Autor:
Luned M Badder, Andrew J Hollins, Bram Herpers, Kuan Yan, Kenneth B Ewan, Mairian Thomas, Jennifer R Shone, Delyth A Badder, Marc Naven, Kevin E Ashelford, Rachel Hargest, Alan R Clarke, Christina Esdar, Hans-Peter Buchstaller, J Mark Treherne, Sylvia Boj, Bahar Ramezanpour, Dirk Wienke, Leo S Price, Paul H Shaw, Trevor C Dale
Publikováno v:
PLoS ONE, Vol 15, Iss 8, p e0235319 (2020)
Aberrant activation of the Wnt signalling pathway is required for tumour initiation and survival in the majority of colorectal cancers. The development of inhibitors of Wnt signalling has been the focus of multiple drug discovery programs targeting c
Externí odkaz:
https://doaj.org/article/7afb5fbeb60b440b90aba42a6bfd295c
Autor:
Rachel Hargest
Publikováno v:
Journal of the Royal Society of Medicine. 114(2)
The last 30 years have seen a revolution in the provision of minimal access surgery for many conditions, and technological advances are increasing exponentially. Many instruments are superseded by improved versions before the NHS and publicly funded
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::299c2db8656adfab8b46fc1e168cf336
https://pubmed.ncbi.nlm.nih.gov/33135951
https://pubmed.ncbi.nlm.nih.gov/33135951
Autor:
Rachel Hargest
Publikováno v:
Journal of the Royal Society of Medicine. 114(1)
Summary This is the second of a three-part series that charts the history of minimal access surgery from antiquity to current times. Although rapid developments in laparoscopic and robotic surgery have transformed surgical care over the last 30 years
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7273ccdf75d283e551d0b5870e8df5a
https://pubmed.ncbi.nlm.nih.gov/33135950
https://pubmed.ncbi.nlm.nih.gov/33135950
Autor:
Rachel Hargest
Publikováno v:
Journal of the Royal Society of Medicine. 113(12)
Summary Surgeons and their patients recognise that one of the major advances in surgical technique over the last 20 years has been the growth of minimal access surgery by means of laparoscopic and robotic approaches. Partnerships with industry have f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ba79b9266c72d2854c5eb4f3a149117
https://pubmed.ncbi.nlm.nih.gov/33565915
https://pubmed.ncbi.nlm.nih.gov/33565915
Autor:
Andrew Godkin, Awen Gallimore, Tom Hockey, Adam Christian, Simon Phillips, Rachel Hargest, Mike Davies, Hayley Bridgeman, Kathryn Smart, Clare Brown, Rohit Srinivasan, Tom Pembroke, Anja Bloom, Martin Scurr
PDF file - 10925K, S. Fig. 1. Cultured 5T4-specific CD4+ T cells can be cloned from CRC patients (A) and healthy donors (B). S. Fig. 2. A comparison of 5T4 responses and age amongst CRC patients. S. Fig. 3. 5T4 Immunohistochemistry staining of frozen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37e4fb6564364670e2df082f05d6e122
https://doi.org/10.1158/2326-6066.22536068.v1
https://doi.org/10.1158/2326-6066.22536068.v1
Autor:
Andrew Godkin, Awen Gallimore, Tom Hockey, Adam Christian, Simon Phillips, Rachel Hargest, Mike Davies, Hayley Bridgeman, Kathryn Smart, Clare Brown, Rohit Srinivasan, Tom Pembroke, Anja Bloom, Martin Scurr
The relationship between the adaptive CD4+ T-cell response and human cancer is unclear. The oncofetal antigen 5T4 is expressed in many human carcinomas, including colorectal cancer cells, but has limited expression on normal tissues. We previously id
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b1bf0a7180aec6b54e1db4cf624551e
https://doi.org/10.1158/2326-6066.c.6548039.v1
https://doi.org/10.1158/2326-6066.c.6548039.v1
Autor:
Andrew Godkin, Awen Gallimore, Tom Hockey, Adam Christian, Simon Phillips, Rachel Hargest, Mike Davies, Hayley Bridgeman, Kathryn Smart, Clare Brown, Rohit Srinivasan, Tom Pembroke, Anja Bloom, Martin Scurr
PDF file - 65K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4188c8de9b64c796beb387924f72e320
https://doi.org/10.1158/2326-6066.22536071.v1
https://doi.org/10.1158/2326-6066.22536071.v1
Autor:
Andrew Godkin, Awen Gallimore, Richard J. Stanton, Alan L. Parker, Robert Andrews, Kevin E. Ashelford, Adam D. Christian, Simon Phillips, Rachel Hargest, Michael M. Davies, James A. Davies, Stephanie E.A. Burnell, Sarah L. Hulin-Curtis, Yuan Chen, Michelle S. Somerville, Emma Campbell, Alex Greenshields-Watson, Martin J. Scurr
Purpose:Broadly expressed, highly differentiated tumor-associated antigens (TAA) can elicit antitumor immunity. However, vaccines targeting TAAs have demonstrated disappointing clinical results, reflecting poor antigen selection and/or immunosuppress
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::906d7bca2872e6feb04d0114a8d7a38f
https://doi.org/10.1158/1078-0432.c.6529380.v1
https://doi.org/10.1158/1078-0432.c.6529380.v1