Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Rachel H. Hsu"'
Autor:
Marco De Giorgi, Kelsey E. Jarrett, Jason C. Burton, Alexandria M. Doerfler, Ayrea Hurley, Ang Li, Rachel H. Hsu, Mia Furgurson, Kalyani R. Patel, Jun Han, Christoph H. Borchers, William R. Lagor
Publikováno v:
Journal of Lipid Research, Vol 61, Iss 12, Pp 1675-1686 (2020)
HMG-CoA reductase (Hmgcr) is the rate-limiting enzyme in the mevalonate pathway and is inhibited by statins. In addition to cholesterol, Hmgcr activity is also required for synthesizing nonsterol isoprenoids, such as dolichol, ubiquinone, and farnesy
Externí odkaz:
https://doaj.org/article/ed795593e77944b1aba45644fccaf0d5
Autor:
Mia Furgurson, Ayrea Hurley, Jun Han, Alexandria M. Doerfler, Ang Li, Jason C. Burton, Christoph H. Borchers, Marco De Giorgi, William R. Lagor, Rachel H. Hsu, Kalyani R. Patel, Kelsey E Jarrett
Publikováno v:
J Lipid Res
Journal of Lipid Research, Vol 61, Iss 12, Pp 1675-1686 (2020)
Journal of Lipid Research, Vol 61, Iss 12, Pp 1675-1686 (2020)
HMG-CoA reductase (Hmgcr) is the rate-limiting enzyme in the mevalonate pathway and is inhibited by statins. In addition to cholesterol, Hmgcr activity is also required for synthesizing nonsterol isoprenoids, such as dolichol, ubiquinone, and farnesy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::770616831edb479aac432495d2555db3
Autor:
Kelsey E Jarrett, Alexandria M. Doerfler, Marco De Giorgi, William R. Lagor, Ciaran M. Lee, Henry J. Pownall, Ang Li, Gang Bao, Ayrea Hurley, Rachel H. Hsu
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 38
Background: Current methods to study genetic contributions to atherosclerosis are time-consuming and expensive. The Ldlr and Apoe knockout (KO) models are currently the gold-standard, but require extensive backcrossing to homozygosity and congenic st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::06a35c79f75ec76ab1733022effe8294
https://doi.org/10.1161/atvb.38.suppl_1.032
https://doi.org/10.1161/atvb.38.suppl_1.032
Autor:
Marco De Giorgi, Ayrea Hurley, William R. Lagor, Kelsey E Jarrett, Jason C. Burton, Rachel H. Hsu, Alexandria M. Doerfler
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 38
Hmg-CoA Reductase (Hmgcr) catalyzes the conversion of Hmg-CoA to mevalonate, which is the rate-limiting step in the cholesterol biosynthetic pathway. Hmgcr is the target of statins, which are the front line therapy for hypercholesterolemia. Statin-re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e3b9759467989c063da5052dd58f33d
https://doi.org/10.1161/atvb.38.suppl_1.216
https://doi.org/10.1161/atvb.38.suppl_1.216
Autor:
James F. Martin, Perla J. Rodriguez, Chang Seok Lee, Min Zhang, Baiba K. Gillard, William R. Lagor, Ciaran M. Lee, Rachel H. Hsu, Henry J. Pownall, Karl-Dimiter Bissig, Kelsey E Jarrett, Rajat Gupta, Gang Bao, Yi-Hsien Yeh
Publikováno v:
Scientific Reports
Germline manipulation using CRISPR/Cas9 genome editing has dramatically accelerated the generation of new mouse models. Nonetheless, many metabolic disease models still depend upon laborious germline targeting, and are further complicated by the need
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0871939032d72446ae4dce1aa8f6f56c