Zobrazeno 1 - 10 of 13 pro vyhledávání: '"Rachel H Wilson"'
1
Akademický článek
Disruption of canonical AHR-mediated induction of hepatocyte PKM2 expression compromises antioxidant defenses and increases TCDD-induced hepatotoxicity
Autor: Karina Orlowska, Rance Nault, Jesmin Ara, John J. LaPres, Jack Harkema, Elena Y. Demireva, Huirong Xie, Rachel H. Wilson, Christopher A. Bradfield, Dianne Yap, Aditya Joshi, Cornelis J. Elferink, Tim Zacharewski
Publikováno v: Redox Biology, Vol 77, Iss , Pp 103405- (2024)
Metabolic reprogramming by the pyruvate kinase M2 isoform is associated with cell proliferation and reactive oxygen species (ROS) defenses. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), an environmental contaminant that induces ROS and hepatotoxicity,
Externí odkaz: https://doaj.org/article/023a274e1ddd498c9e7194f464b1c96a
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3
Regional variation in cardiovascular genes enables a tractable genome editing strategy
Autor: Vikki A. Krysov, Rachel H. Wilson, Nicholas S. Ten, Nathan Youlton, Hannah N. De Jong, Shirley Sutton, Yong Huang, Chloe Reuter, Megan E. Grove, Matthew T. Wheeler, Euan A. Ashley, Victoria N. Parikh
Recent rise in the number and therapeutic potential of genome engineering technologies has generated excitement in cardiovascular genetics. One significant barrier to their implementation is costly and time consuming reagent development for novel uni
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1c07bb2673b5db216ff6dcdc24c9a849
https://doi.org/10.1101/2022.03.03.22271786
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4
The Ah Receptor: Adaptive Metabolism, Ligand Diversity, and the Xenokine Model
Autor: Rachel H Wilson, Mark E. Hahn, Christopher A. Bradfield, Kristen Malecki, Mele N Avilla
Publikováno v: Chemical Research in Toxicology
The Ah receptor (AHR) has been studied for almost five decades. Yet, we still have many important questions about its role in normal physiology and development. Moreover, we still do not fully understand how this protein mediates the adverse effects
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41d13ecbe00b419a76695f1aee841003
https://doi.org/10.1021/acs.chemrestox.9b00476
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6
Rodent genetic models of Ah receptor signaling
Autor: Rachel H Wilson, Christopher A. Bradfield
Publikováno v: Drug Metab Rev
The aryl hydrocarbon receptor (AHR) is a ligand activated transcription factor that is a member of the PER-ARNT-SIM superfamily of environmental sensors. This receptor has been a molecule of interest for many years in the field of toxicology, as it w
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fe1cc48c9f47a0333d1eb6d7e434c49
https://pubmed.ncbi.nlm.nih.gov/34289754
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7
Generation of an Allelic Series at the Ahr Locus Using an Edited Recombinant Approach
Autor: Jeremiah S. Yee, Rachel H Wilson, Clifford Dustin Rubinstein, Nicholas A Goetz, Jessica C. Parrott, Manabu Nukaya, Susan M. Moran, E.W.N. Glover, Brenda L Rojas, Kathy J. Krentz, Christopher A. Bradfield, Yongna Xing, Patrick R. Carney
Publikováno v: Toxicol Sci
The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor and a member of the PER-ARNT-SIM (PAS) superfamily of environmental sensors. The AHR is involved in a series of biological processes including adaptive metabolism of xenob
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6495cb26c6b27a21188fb4bb35ec4db
https://pubmed.ncbi.nlm.nih.gov/33480436
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10
Akademický článek
Rodent genetic models of Ah receptor signaling.
Autor: Wilson, Rachel H.1,2 (AUTHOR), Bradfield, Christopher A.1,2,3 (AUTHOR)
Publikováno v: Drug Metabolism Reviews. Aug 2021, Vol. 53 Issue 3, p350-374. 25p.
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