Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Rachel H Fong"'
Autor:
Jarrod J Mousa, Elad Binshtein, Stacey Human, Rachel H Fong, Gabriela Alvarado, Benjamin J Doranz, Martin L Moore, Melanie D Ohi, James E Crowe
Publikováno v:
PLoS Pathogens, Vol 14, Iss 2, p e1006837 (2018)
Respiratory syncytial virus (RSV) is a major human pathogen that infects the majority of children by two years of age. The RSV fusion (F) protein is a primary target of human antibodies, and it has several antigenic regions capable of inducing neutra
Externí odkaz:
https://doaj.org/article/ffc611f2544f42be8d3e1eb19368079d
Autor:
Suganya Selvarajah, Nicole R Sexton, Kristen M Kahle, Rachel H Fong, Kimberly-Anne Mattia, Joy Gardner, Kai Lu, Nathan M Liss, Beatriz Salvador, David F Tucker, Trevor Barnes, Manu Mabila, Xiangdong Zhou, Giada Rossini, Joseph B Rucker, David Avram Sanders, Andreas Suhrbier, Vittorio Sambri, Alain Michault, Marcus O Muench, Benjamin J Doranz, Graham Simmons
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 7, Iss 9, p e2423 (2013)
The mosquito-borne alphavirus, chikungunya virus (CHIKV), has recently reemerged, producing the largest epidemic ever recorded for this virus, with up to 6.5 million cases of acute and chronic rheumatic disease. There are currently no licensed vaccin
Externí odkaz:
https://doaj.org/article/8169a058b1b3485d96513f63bdd55e09
Autor:
Rachel H. Fong, Benjamin J. Doranz, John T. Roehrig, Susan L. Bennett, Amanda E. Calvert, Ann R. Hunt, Carol D. Blair
Publikováno v:
Virology
Eastern equine encephalitis virus (EEEV), western equine encephalitis virus (WEEV) and Venezuelan equine encephalitis virus (VEEV) can cause fatal encephalitis in humans and equids. Some MAbs to the E1 glycoprotein are known to be cross-reactive, wea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b73b703321032527110036020589f3d6
https://doi.org/10.1016/j.virol.2021.09.007
https://doi.org/10.1016/j.virol.2021.09.007
Autor:
Jing Jin, Nathan M. Liss, Dong-Hua Chen, Maofu Liao, Julie M. Fox, Raeann M. Shimak, Rachel H. Fong, Daniel Chafets, Sonia Bakkour, Sheila Keating, Marina E. Fomin, Marcus O. Muench, Michael B. Sherman, Benjamin J. Doranz, Michael S. Diamond, Graham Simmons
Publikováno v:
Cell Reports, Vol 13, Iss 11, Pp 2553-2564 (2015)
We evaluated the mechanism by which neutralizing human monoclonal antibodies inhibit chikungunya virus (CHIKV) infection. Potently neutralizing antibodies (NAbs) blocked infection at multiple steps of the virus life cycle, including entry and release
Externí odkaz:
https://doaj.org/article/73ebf265434a4ebbbb248581331d2655
Autor:
Joseph Rucker, Rachel H. Fong, Tabb Sullivan, Carmen Navia, Brad Screnci, Rona Wilf, Benjamin J. Doranz
Publikováno v:
Cancer Research. 83:2646-2646
Rigorous specificity analysis is critical for the development of antibody-based therapies, as even minimal off-target binding can lead to toxicity and clinical failures. Long believed to be exquisitely specific, recent preclinical data and our own wo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cdec5dca593a7da126c4c78ab976761d
https://doi.org/10.1158/1538-7445.am2023-2646
https://doi.org/10.1158/1538-7445.am2023-2646
Autor:
Subhajit Poddar, Rong Zhang, Hueylie Lin, Daved H. Fremont, Rachel H. Fong, Arthur S. Kim, William B. Klimstra, Julie M. Fox, James E. Crowe, Katherine Basore, Benjamin J. Doranz, Rebecca Rimkunas, Michael S. Diamond, Sharmila Nair
Publikováno v:
Nature
Arthritogenic alphaviruses comprise a group of enveloped RNA viruses that are transmitted to humans by mosquitoes and cause debilitating acute and chronic musculoskeletal disease 1 . The host factors required for alphavirus entry remain poorly charac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a43c606b2f56f7556db265abc10b89c
https://doi.org/10.1038/s41586-018-0121-3
https://doi.org/10.1038/s41586-018-0121-3
Autor:
Natasha M. Kafai, Lo Vang, Lauren E. Williamson, Michael S. Diamond, Prashant N. Jethva, Michael L. Gross, Arthur S. Kim, William B. Klimstra, Paulina Kaplonek, Jose A. Quiroz, Daved H. Fremont, Aadit P. Shah, Matthias Mack, Emma S. Winkler, Jonathan R. Lai, Benjamin J. Doranz, Galit Alter, Emily L. Cottle, James E. Crowe, Ryan J. Malonis, Theron C. Gilliland, Edgar Davidson, Rachel H. Fong, James T. Earnest
Publikováno v:
Cell
Alphaviruses are emerging, mosquito-transmitted pathogens that cause musculoskeletal and neurological disease in humans. Although neutralizing antibodies that inhibit individual alphaviruses have been described, broadly reactive antibodies that prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::899a986b3c48dadf4f520a3ed9a5d341
https://doi.org/10.1016/j.cell.2021.07.006
https://doi.org/10.1016/j.cell.2021.07.006
Autor:
Maofu Liao, Marina E. Fomin, Graham Simmons, Daniel M. Chafets, Sheila M. Keating, Nathan M. Liss, Rachel H. Fong, Benjamin J. Doranz, Michael B. Sherman, Dong-Hua Chen, Raeann M. Shimak, Sonia Bakkour, Marcus O. Muench, Jing Jin, Michael S. Diamond, Julie M. Fox
Publikováno v:
Cell Reports, Vol 13, Iss 11, Pp 2553-2564 (2015)
SummaryWe evaluated the mechanism by which neutralizing human monoclonal antibodies inhibit chikungunya virus (CHIKV) infection. Potently neutralizing antibodies (NAbs) blocked infection at multiple steps of the virus life cycle, including entry and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4b351c7ef56a9b888893be9bdb3c742
https://doi.org/10.1016/j.celrep.2015.11.043
https://doi.org/10.1016/j.celrep.2015.11.043
Autor:
Wataru Akahata, Zhenguo Chen, Andrei Fokine, Thomas Klose, James E. Crowe, Rachel H. Fong, Michael G. Rossmann, Michael S. Diamond, Yue Liu, Feng Long, Stephen K. Austin, Benjamin J. Doranz, Jason Porta, Gopal Sapparapu
Publikováno v:
Proceedings of the National Academy of Sciences. 112:13898-13903
Chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus that causes severe acute and chronic disease in humans. Although highly inhibitory murine and human monoclonal antibodies (mAbs) have been generated, the structural basis of their neutral
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f15f95397f1c99d7dddc30e0beb132b6
https://doi.org/10.1073/pnas.1515558112
https://doi.org/10.1073/pnas.1515558112
Autor:
Benjamin J. Doranz, Hao Yan, Melanie Horton, Aimin Tang, Sheri Dubey, Danilo R. Casimiro, Zhifeng Chen, Daniel J. DiStefano, Kalpit A. Vora, Xin-Min Wang, Rachel H. Fong, Kara S. Cox, Andrew Ettenger
Publikováno v:
mAbs
Monitoring antigen-specific memory B cells and the antibodies they encode is important for understanding the specificity, breadth and duration of immune response to an infection or vaccination. The antibodies isolated could further help design vaccin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::768646b2b83f97308ac4310de46c89e1
https://doi.org/10.1080/19420862.2015.1109757
https://doi.org/10.1080/19420862.2015.1109757