Zobrazeno 1 - 10
of 481
pro vyhledávání: '"Rachel F Tyndale"'
Autor:
Kelley J. Jansen, Brianna N. Tranby, Aliassa L. Shane, Todd Takeno, Kelly Chadwick, Pamela Sinicrope, Jennifer L. Shaw, Rachel F. Tyndale, Jeffrey R. Harris, Christi A. Patten, Jaedon P. Avey
Publikováno v:
Archives of Public Health, Vol 82, Iss 1, Pp 1-9 (2024)
Abstract Background Individualized treatment for commercial tobacco smoking cessation, such as through the utilization of the nicotine metabolite ratio (NMR), offers potential clinical benefit. NMR is a metabolism-informed biomarker that can be used
Externí odkaz:
https://doaj.org/article/a52d11a2f096474395d119742bc68225
Autor:
Scott S. Lee, Nicole Senft Everson, Maureen Sanderson, Rebecca Selove, William J. Blot, Stephen King, Karen Gilliam, Suman Kundu, Mark Steinwandel, Sarah J. Sternlieb, Qiuyin Cai, Shaneda Warren Andersen, Debra L. Friedman, Erin Connors Kelly, Mary Kay Fadden, Matthew S. Freiberg, Quinn S. Wells, Juan Canedo, Rachel F. Tyndale, Robert P. Young, Raewyn J. Hopkins, Hilary A. Tindle
Publikováno v:
Addiction Science & Clinical Practice, Vol 19, Iss 1, Pp 1-12 (2024)
Abstract Background The feasibility of precision smoking treatment in socioeconomically disadvantaged communities has not been studied. Methods Participants in the Southern Community Cohort Study who smoked daily were invited to join a pilot randomiz
Externí odkaz:
https://doaj.org/article/d106c37905634403b939d73fc60e9ef6
Autor:
Andrew W Bergen, Martha Michel, Denise Nishita, Ruth Krasnow, Harold S Javitz, Karen N Conneely, Christina N Lessov-Schlaggar, Hyman Hops, Andy Z X Zhu, James W Baurley, Jennifer B McClure, Sharon M Hall, Timothy B Baker, David V Conti, Neal L Benowitz, Caryn Lerman, Rachel F Tyndale, Gary E Swan, Transdisciplinary Research in Cancer of the Lung Research Team
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0126113 (2015)
The Nicotine Metabolite Ratio (NMR, ratio of trans-3'-hydroxycotinine and cotinine), has previously been associated with CYP2A6 activity, response to smoking cessation treatments, and cigarette consumption. We searched for drug metabolizing enzyme an
Externí odkaz:
https://doaj.org/article/482e4745ab7b45ce912e61d8e8237ff7
Autor:
Rachel F Tyndale, Andy Z X Zhu, Tony P George, Paul Cinciripini, Larry W Hawk, Robert A Schnoll, Gary E Swan, Neal L Benowitz, Daniel F Heitjan, Caryn Lerman, PGRN-PNAT Research Group
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0128109 (2015)
CHRNA5-A3-B4 variants, rs16969968, rs588765 and rs578776, are consistently associated with tobacco consumption among smokers, but the association with smoking cessation is less consistent. Among the studies that reported significant associations with
Externí odkaz:
https://doaj.org/article/08ad16306e92446085e4a3ce871ff0e8
Autor:
Shakir D Alsharari, Justin R King, Jacob C Nordman, Pretal P Muldoon, Asti Jackson, Andy Z X Zhu, Rachel F Tyndale, Nadine Kabbani, M Imad Damaj
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0137070 (2015)
Although menthol, a common flavoring additive to cigarettes, has been found to impact the addictive properties of nicotine cigarettes in smokers little is known about its pharmacological and molecular actions in the brain. Studies were undertaken to
Externí odkaz:
https://doaj.org/article/1bec6611c1144482a1b52f86266bcd64
Autor:
Anu Loukola, Jadwiga Buchwald, Richa Gupta, Teemu Palviainen, Jenni Hällfors, Emmi Tikkanen, Tellervo Korhonen, Miina Ollikainen, Antti-Pekka Sarin, Samuli Ripatti, Terho Lehtimäki, Olli Raitakari, Veikko Salomaa, Richard J Rose, Rachel F Tyndale, Jaakko Kaprio
Publikováno v:
PLoS Genetics, Vol 11, Iss 9, p e1005498 (2015)
Individuals with fast nicotine metabolism typically smoke more and thus have a greater risk for smoking-induced diseases. Further, the efficacy of smoking cessation pharmacotherapy is dependent on the rate of nicotine metabolism. Our objective was to
Externí odkaz:
https://doaj.org/article/dbdbd382618a4a53a6714feb5d998c29
Autor:
Andy Z X Zhu, Qian Zhou, Lisa Sanderson Cox, Jasjit S Ahluwalia, Neal L Benowitz, Rachel F Tyndale
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e70938 (2013)
CYP2A6 metabolizes nicotine to its primary metabolite cotinine and also mediates the metabolism of cotinine to trans-3'-hydroxycotinine (3HC). The ratio of 3HC to cotinine (the "nicotine metabolite ratio", NMR) is an in vivo marker for the rate of CY
Externí odkaz:
https://doaj.org/article/b01d5c7dac6d4ba387c9271b14a1c3d0
Autor:
Ian Mahar, Rosemary C Bagot, Maria Antonietta Davoli, Sharon Miksys, Rachel F Tyndale, Claire-Dominique Walker, Marissa Maheu, Sheng-Hai Huang, Tak Pan Wong, Naguib Mechawar
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e37219 (2012)
The influence of developmental nicotine exposure on the brain represents an important health topic in light of the popularity of nicotine replacement therapy (NRT) as a smoking cessation method during pregnancy.In this study, we used a model of NRT d
Externí odkaz:
https://doaj.org/article/df1c9426053b475295e314d66883f37b
Autor:
Christine Ibrahim, Victor M. Tang, Daniel M. Blumberger, Saima Malik, Rachel F. Tyndale, Alisson P. Trevizol, Mera S. Barr, Zafiris J. Daskalakis, Abraham Zangen, Bernard Le Foll
Publikováno v:
Brain Stimulation, Vol 16, Iss 5, Pp 1501-1509 (2023)
Background: Current smoking cessation treatments are limited in terms of efficacy, particularly with regards to long term abstinence. There is a large amount of evidence implicating the insula in nicotine addiction. Objective: To examine the efficacy
Externí odkaz:
https://doaj.org/article/a794a60f98b74fe39c929a7ca457f10e
Autor:
Van Thi Thanh Truong, Charles Green, Claudia Pedroza, Lu-Yu Hwang, Suja S. Rajan, Robert Suchting, Paul Cinciripini, Rachel F. Tyndale, Caryn Lerman
Publikováno v:
BMC Medical Research Methodology, Vol 23, Iss 1, Pp 1-11 (2023)
Abstract Background Research on risk factors for neuropsychiatric adverse events (NAEs) in smoking cessation with pharmacotherapy is scarce. We aimed to identify predictors and develop a prediction model for risk of NAEs in smoking cessation with med
Externí odkaz:
https://doaj.org/article/efd42060311f41f18beedb1ba07a1e0e