Výsledky vyhledávání - "Rachel E. Nally"

Eicosapentaenoic acid confers neuroprotection in the amyloid-β challenged aged hippocampus

Autor: Dana Kilroy, David J. Loane, Marina A. Lynch, Florence O’Connell, Aileen M. Lynch, Rachel E. Nally, Aedín M. Minogue, Óran J. Roche, Rachael M. Clarke

Publikováno v: Neurobiology of Aging. 28:845-855

Among the changes that occur in the hippocampus with age, is a deficit in long-term potentiation (LTP). This impairment is associated with inflammatory changes, which are typified by increased concentration of the pro-inflammatory cytokine interleuki

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5c0d682100d8cc5cb3ab65001f81269
https://doi.org/10.1016/j.neurobiolaging.2006.04.006

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Interaction between interferon ? and insulin-like growth factor-1 in hippocampus impacts on the ability of rats to sustain long-term potentiation

Autor: Rachel E. Nally, Frank O. Maher, Marina A. Lynch, Rachael M. Clarke, Áine M. Kelly

Publikováno v: Journal of Neurochemistry. 96:1560-1571

There is compelling evidence to suggest that inflammation significantly contributes to neurodegenerative changes. Consistent with this is the observation that several neurodegenerative disorders are accompanied by an increase in the concentration of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9993b8f655515938d3557af17e8bcc2d
https://doi.org/10.1111/j.1471-4159.2006.03664.x

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Ethologically Based Resolution of D2-Like Dopamine Receptor Agonist-versus Antagonist-Induced Behavioral Topography in Dopamine- and Adenosine 3′,5′-Monophosphate-Regulated Phosphoprotein of 32 kDa 'Knockout' Mutants Congenic on the C57BL/6 Genetic Background

Autor: Orna Tighe, Allen A. Fienberg, Paul Greengard, John L. Waddington, Anthony Kinsella, Rachel E. Nally, David T. Croke

Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 310:1281-1287

Given the critical role of dopamine- and adenosine 3′,5′-monophosphate-regulated phosphoprotein of 32 kDa (DARPP-32) in the regulation of dopaminergic function, DARPP-32-null mutant mice congenic on the inbred C57BL/6 strain for 10 generations we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1666ca528ddcc6ea13c504278ffd471c
https://doi.org/10.1124/jpet.104.068957

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Autor: Yvonne McCartney, Yvonne M. Nolan, Rebecca J. Griffin, Marina A. Lynch, Rachel E. Nally, James Linden

Publikováno v: Journal of neurochemistry. 99(4)

It is well established that inflammatory changes contribute to brain ageing, and an increased concentration of proinflammatory cytokine, interleukin-1beta (IL-1beta), has been reported in the aged brain associated with a deficit in long-term potentia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::510ad057cd2b912f463d8f5125cd3f0a
https://pubmed.ncbi.nlm.nih.gov/16981890

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Disruption of orofacial movement topographies in congenic mutants with dopamine D5 but not D4 receptor or DARPP-32 transduction 'knockout'

Autor: Katsunori Tomiyama, David T. Croke, Rachel E. Nally, Orna Tighe, Yasuyuki Makihara, David R. Sibley, Gerard J. O'Sullivan, Allen A. Fienberg, Hiroshi Yamamoto, David K. Grandy, John L. Waddington, Anthony Kinsella, Noriaki Koshikawa

Publikováno v: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. 16(6)

The role of D(1)-like [D(1), D(5)] and D(2)-like [D(2), D(3), D(4)] dopamine receptors and dopamine transduction via DARPP-32 in topographies of orofacial movement was assessed in restrained mice with congenic D(4) vs. D(5) receptor vs. DARPP-32 'kno

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acc853f429b471e809276c24d64856df
https://pubmed.ncbi.nlm.nih.gov/16413758

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Ethologically based resolution of D2-like dopamine receptor agonist-versus antagonist-induced behavioral topography in dopamine- and adenosine 3',5'-monophosphate-regulated phosphoprotein of 32 kDa 'knockout' mutants congenic on the C57BL/6 genetic background

Autor: Rachel E, Nally, Anthony, Kinsella, Orna, Tighe, David T, Croke, Allen A, Fienberg, Paul, Greengard, John L, Waddington

Publikováno v: The Journal of pharmacology and experimental therapeutics. 310(3)

Given the critical role of dopamine- and adenosine 3',5'-monophosphate-regulated phosphoprotein of 32 kDa (DARPP-32) in the regulation of dopaminergic function, DARPP-32-null mutant mice congenic on the inbred C57BL/6 strain for 10 generations were e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::aea7e77eea37a9fe6a2a7c89d2c494bf
https://pubmed.ncbi.nlm.nih.gov/15140917

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Topographical Assessment of Ethological and Dopamine Receptor Agonist-Induced Behavioral Phenotype in Mutants with Congenic DARPP-32 'Knockout'

Autor: Orna Tighe, David T. Croke, Rachel E. Nally, Jeremiah J Clifford, Paul Greengard, Allen A. Fienberg, Fergal N McNamara, John L. Waddington, Anthony Kinsella

Publikováno v: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 28(12)

Congenic (10 backcrosses into C57BL/6J) mutants with targeted gene deletion of DARPP-32, a neuronal phosphoprotein regarded as an essential mediator of the biological effects of dopamine (DA), were assessed phenotypically using an ethologically based

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::905504153931cb7a4e96fd180f9019bd
https://pubmed.ncbi.nlm.nih.gov/12865890

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