Výsledky vyhledávání - "Rachel E. Kohler"

In vivo expansion of T reg cells with IL-2–mAb complexes: induction of resistance to EAE and long-term acceptance of islet allografts without immunosuppression

Autor: Tomas Mrkvan, Kylie E. Webster, Onur Boyman, Shane T. Grey, Charles D. Surh, Stacey N. Walters, Rachel E. Kohler, Jonathan Sprent

Publikováno v: Journal of Experimental Medicine, vol. 206, no. 4, pp. 751-760
The Journal of Experimental Medicine

Via a transcription factor, Foxp3, immunoregulatory CD4+CD25+ T cells (T reg cells) play an important role in suppressing the function of other T cells. Adoptively transferring high numbers of T reg cells can reduce the intensity of the immune respon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b28d10dbf3125e5880c71de9dc1e813
https://doi.org/10.1084/jem.20082824

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A Role for Macrophage Inflammatory Protein-3α/CC Chemokine Ligand 20 in Immune Priming During T Cell-Mediated Inflammation of the Central Nervous System

Autor: David O. Willenborg, Adriana C. Caon, Shaun R. McColl, Ian Clark-Lewis, Rachel E. Kohler

Publikováno v: The Journal of Immunology. 170:6298-6306

Chemokines are a family of cytokines that exhibit selective chemoattractant properties for target leukocytes and play a significant role in leukocyte migration. In this study, we have investigated the role of the C-C chemokine, macrophage inflammator

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef6d4b61f9bea8ee3c778709d561fa03
https://doi.org/10.4049/jimmunol.170.12.6298

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Inhibition of CCR6 Function Reduces the Severity of Experimental Autoimmune Encephalomyelitis via Effects on the Priming Phase of the Immune Response

Autor: Rachel E. Kohler, Heinrich Körner, Iain Comerford, Adrian Liston, Adriana C. Caon, Ian Clark-Lewis, Sarah Haylock-Jacobs, Shaun R. McColl, Julie Webster, Scott L. Townley, Jodie M. Harrison, Jeremy Swann

Chemokines are essential for homeostasis and activation of the immune system. The chemokine ligand/receptor pairing CCL20/CCR6 is interesting because these molecules display characteristics of both homeostatic and activation functions. These dual cha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d38738a6cbec7c7249b480b822ee4fcc
https://lirias.kuleuven.be/handle/123456789/256628

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Direct stimulation of T cells by membrane vesicles from antigen-presenting cells

Autor: Inkyu Hwang, Jonathan Sprent, Marek Kovar, Rachel E. Kohler, Onur Boyman, Xuefei Shen

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 103(31)

Activation of naïve T cells generally requires T cell receptor-mediated contact with MHC-bound peptides on viable antigen-presenting cells such as dendritic cells (DC). Here evidence is presented that dissociated cell membrane fragments from a DC li

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::324d8ceda1edbb7b481195d923fc35fe
https://pubmed.ncbi.nlm.nih.gov/16855047

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Antagonism of the Chemokine Receptors CXCR3 and CXCR4 Reduces the Pathology of Experimental Autoimmune Encephalomyelitis

Autor: Scott L. Townley, Sarah Haylock-Jacobs, Ian Clark-Lewis, Iain Comerford, Rachel E. Kohler, Shaun R. McColl

Publikováno v: Brain Pathol

Chemokines regulate lymphocyte trafficking under physiologic and pathologic conditions. In this study, we have investigated the role of CXCR3 and CXCR4 in the activation of T lymphocytes and their migration to the central nervous system (CNS) using n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcbf77e2a029cb72fca6798224433ce4
https://doi.org/10.1111/j.1750-3639.2008.00154.x

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