Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Rachel E. Johns"'
Autor:
Elzette Rousseau, Linxuan Wu, Renee Heffron, Jared M. Baeten, Connie L. Celum, Danielle Travill, Sinead Delany-Moretlwe, Linda-Gail Bekker, Elizabeth Bukusi, Victor Omollo, Ariane van der Straten, Gabrielle O’Malley, Jessica E. Haberer, Jennifer F. Morton, Rachel E. Johnson, Sarah T. Roberts
Publikováno v:
Frontiers in Reproductive Health, Vol 5 (2023)
IntroductionGendered power inequalities impact adolescent girls’ and young women's (AGYW) sexual and reproductive health (SRH) outcomes. We investigated the influence of sexual relationship power on AGYW's SRH outcomes, including HIV pre-exposure p
Externí odkaz:
https://doaj.org/article/5e59d517993e401a8e4572364d7e5bf1
Publikováno v:
Therapeutic Delivery. 3:245-261
RNAi-based approaches provide a promising therapeutic modality for the treatment of cancer. The inaccessibility of tumors in different cancer types necessitates the development of safe, specific and efficient systemic delivery systems to meet therape
Autor:
Yan Chen, Erin Kwang, Rachel E. Johns, Renata Fam, Michael McCutcheon, Feng Chen, Alan So, Gregory Severson, Barry Polisky, Michael V. Templin, Yoshiyuki Matsui, Roger C. Adami, Tod Brown, Kathy Fosnaugh, Iwona M. Maciagiewicz, Pierrot Harvie, Yan Liu, Shaguna Seth, Akihide Takagi, Narendra K. Vaish, Tianying Zhu, Susan Bell, Ken Farber, Michael E. Houston, Patrick Charmley
Publikováno v:
Molecular Therapy. 19(5):928-935
Harnessing RNA interference (RNAi) to silence aberrant gene expression is an emerging approach in cancer therapy. Selective inhibition of an overexpressed gene via RNAi requires a highly efficacious, target-specific short interfering RNA (siRNA) and
Autor:
Michael E. Houston, Brian R. Granger, Yan Liu, Gregory Severson, Shaguna Seth, Barry Polisky, Roger C. Adami, Rachel E. Johns, Feng Chen, Patrick Charmley, Pierrot Harvie, Tod Brown, Kathy Fosnaugh, Narendra K. Vaish, Michael V. Templin, Yan Chen
Publikováno v:
Nucleic Acids Research
siRNAs confer sequence specific and robust silencing of mRNA. By virtue of these properties, siRNAs have become therapeutic candidates for disease intervention. However, their use as therapeutic agents can be hampered by unintended off-target effects
Autor:
Narendra K. Vaish, Tianying Zhu, Yan Liu, Thomas T Goodman, Ken Farber, Greg Severson, Shaguna Seth, Roger C. Adami, Tod Brown, Michael E. Houston, Pierrot Harvie, Rachel E. Johns, Barry Polisky, Renata Fam, Yan Chen, Patrick Charmley, Kathy Fosnaugh, Feng Chen, Michael McCutcheon, Erin Kwang, Michael V. Templin
We demonstrate a systematic and rational approach to create a library of natural and modified, dialkylated amino acids based upon arginine for development of an efficient small interfering RNA (siRNA) delivery system. These amino acids, designated Di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b46bff2e91a6cfd8c94e84dc865af2eb
https://europepmc.org/articles/PMC3129796/
https://europepmc.org/articles/PMC3129796/
Autor:
Allan S. Hoffman, Joseph Cuschieri, Volga Bulmus, Mohamed E. H. ElSayed, Rachel E. Johns, Ronald V. Maier, Patrick S. Stayton
Publikováno v:
Journal of biomaterials science. Polymer edition. 19(10)
An excessive inflammatory response is a clinical problem following major infections and severe injury that may lead to Sepsis Syndrome and Multiple Organ Failure (MOF), including the Acute Respiratory Distress Syndrome (ARDS). Management of excessive
Autor:
Gabrielle O'Malley, Kristin M. Beima-Sofie, Stephanie D. Roche, Elzette Rousseau, Danielle Travill, Victor Omollo, Sinead Delany-Moretlwe, Linda-Gail Bekker, Elizabeth A. Bukusi, John Kinuthia, Gena Barnabee, Julie C. Dettinger, Anjuli D. Wagner, Jillian Pintye, Jennifer F. Morton, Rachel E. Johnson, Jared M. Baeten, Grace John-Stewart, Connie L. Celum
Publikováno v:
Frontiers in Reproductive Health, Vol 3 (2021)
Background: Successful integration of pre-exposure prophylaxis (PrEP) with existing reproductive health services will require iterative learning and adaptation. The interaction between the problem-solving required to implement new interventions and h
Externí odkaz:
https://doaj.org/article/7946cbb7937c4fe78622e2ecc86ba9a6
Autor:
Yoshiyuki Matsui, Greg Severson, Kathy Fosnaugh, Tianying Zhu, Tod Brown, Yan Liu, Shobana Vaidyanathan, Mike Templin, Shaguna Seth, Rachel E. Johns, Pat Charmley, Alan So, Michael E. Houston, Akihide Takagi, Pierrot Harvie, Yan Chen
Publikováno v:
Cancer Research. 72:281-281
Nucleic acid-based therapeutics offer significant promise in treatment of difficult diseases by providing high sequence specificity against target genes including “non-druggable targets”. Different nucleic acid constructs, single-stranded antisen
Autor:
Alan So, Yan Liu, Shaguna Seth, Kathy Fosnaugh, Roger C. Adami, Yoshiyuki Matsui, Rachel E. Johns, Tianying Zhu, Narendra K. Vaish, Gregory Severson, Barry Polisky, Pierrot Harvie, Yan Chen, Michael V. Templin, Pat Charmley, Susan Bell, Brian R. Granger
Publikováno v:
Cancer Research. 70:581-581
Bladder cancer and hepatocellular carcinoma are two of many cancers refractory to current treatments. Small interfering RNAs (siRNAs) are a new therapeutic modality able to specifically silence expression of targets not accessible via current small m
Publikováno v:
Molecular Therapy. 9:S242
Goals and Significance: The inflammatory response, which is initiated upon trauma, infection, or in the presence of a foreign body, is necessary for normal wound healing. However, during chronic inflammation, control of this response becomes clinical