Lymphotoxin-alpha expression in the meninges causes lymphoid tissue formation and neurodegeneration

Autor: Rachel E James Bates, Eleanor Browne, Renee Schalks, Heather Jacobs, Li Tan, Puja Parekh, Roberta Magliozzi, Massimiliano Calabrese, Nicholas D Mazarakis, Richard Reynolds

Publikováno v: Brain. 145:4287-4307

Organized meningeal immune cell infiltrates are suggested to play an important role in cortical grey matter pathology in the multiple sclerosis brain, but the mechanisms involved are as yet unresolved. Lymphotoxin-alpha plays a key role in lymphoid o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd28b5ead48ce1464ea619db7ef7420b
https://doi.org/10.1093/brain/awac232

Meningeal inflammation in multiple sclerosis induces phenotypic changes in cortical microglia that differentially associate with neurodegeneration

Autor: Lydian Knoop, Alwin Kamermans, Susanne M. A. van der Pol, Svenja Kiljan, Marc Franssen, Geert J. Schenk, Carmen Picón, Jack van Horssen, Evelien Drost, Nicholas D. Mazarakis, Sandra Amor, Lynn van Olst, Richard Reynolds, Helga E. de Vries, Rachel E. James, Maarten E. Witte, Iliana Michailidou, Jeroen J. G. Geurts, Carla Rodriguez-Mogeda

Publikováno v: Acta Neuropathologica, 141(6), 881-899. Springer Verlag
van Olst, L, Rodriguez Mogeda, C, Picon, C, Kiljan, S, James, R E, Kamermans, A, van der Pol, S M A, Knoop, L, Michailidou, I, Drost, E, Franssen, M, Schenk, G J, Geurts, J J G, Amor, S, Mazarakis, N D, van Horssen, J, de Vries, H E, Reynolds, R & Witte, M E 2021, ' Meningeal inflammation in multiple sclerosis induces phenotypic changes in cortical microglia that differentially associate with neurodegeneration ', Acta Neuropathologica, vol. 141, no. 6, pp. 881-899 . https://doi.org/10.1007/s00401-021-02293-4
Acta Neuropathologica

Meningeal inflammation strongly associates with demyelination and neuronal loss in the underlying cortex of progressive MS patients, thereby contributing significantly to clinical disability. However, the pathological mechanisms of meningeal inflamma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0957b67feeac3b0e4dfd13e8b3902887
https://research.vumc.nl/en/publications/1f92b2d0-c8fa-4105-bbe6-f8f866702a82

Persistent elevation of intrathecal pro-inflammatory cytokines leads to multiple sclerosis-like cortical demyelination and neurodegeneration

Autor: Richard Reynolds, Rachel E. James, Ioanna Eleftheriadou, Carmen Picon Munoz, Nicholas D. Mazarakis, Renee Schalks, Eleanor Browne

Publikováno v: Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-18 (2020)
Acta Neuropathologica Communications

Analysis of isolated meninges and cerebrospinal fluid (CSF) of post-mortem MS cases has shown increased gene and protein expression for the pro-inflammatory cytokines: tumour necrosis factor (TNF) and interferon-γ (IFNγ). Here we tested the hypothe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3eab17103a92250ac39d30e24ecc110d
http://hdl.handle.net/10044/1/79273

Loss of galectin-3 decreases the number of immune cells in the subventricular zone and restores proliferation in a viral model of multiple sclerosis

Autor: Betty Gration, Stephen D. Miller, David R. Greaves, Istvan Adorjan, Gabriele C. DeLuca, Moon Moon Majumdar, Mayara T.V.V. Mundim, Maureen H. Richards, James M. Hillis, Richard L. Yates, Asif J. Iqbal, Rachel E. James, Gwendolyn E. Goings, Francis G. Szele

Publikováno v: Glia

Multiple sclerosis (MS) frequently starts near the lateral ventricles, which are lined by subventricular zone (SVZ) progenitor cells that can migrate to lesions and contribute to repair. Because MS‐induced inflammation may decrease SVZ proliferatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::add4627b5f9a562e38af624f0f53fc37
https://doi.org/10.1002/glia.22906

Evidence for early specialized processing of speech formant information in anterior and posterior human auditory cortex

Autor: Barrie A, Edmonds, Rachel E, James, Alexander, Utev, Martin D, Vestergaard, Roy D, Patterson, Katrin, Krumbholz

Publikováno v: The European journal of neuroscience. 32(4)

Many speech sounds, such as vowels, exhibit a characteristic pattern of spectral peaks, referred to as formants, the frequency positions of which depend both on the phonological identity of the sound (e.g. vowel type) and on the vocal-tract length of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::32377ee7cec376e6b3a979185037de98
https://pubmed.ncbi.nlm.nih.gov/20646047