Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Rachel E. Hardisty"'
Autor:
Michael Crompton, Tom Purnell, Hayley E Tyrer, Andrew Parker, Greg Ball, Rachel E Hardisty-Hughes, Richard Gale, Debbie Williams, Charlotte H Dean, Michelle M Simon, Ann-Marie Mallon, Sara Wells, Mahmood F Bhutta, Martin J Burton, Hilda Tateossian, Steve D M Brown
Publikováno v:
PLoS Genetics, Vol 13, Iss 8, p e1006969 (2017)
Otitis media (OM), inflammation of the middle ear (ME), is a common cause of conductive hearing impairment. Despite the importance of the disease, the aetiology of chronic and recurrent forms of middle ear inflammatory disease remains poorly understo
Externí odkaz:
https://doaj.org/article/4037f860bf2443118801ffd0087a7524
Autor:
Annalisa Buniello, Rachel E Hardisty-Hughes, Johanna C Pass, Eva Bober, Richard J Smith, Karen P Steel
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e56274 (2013)
The recessive mouse mutant headbobber (hb) displays the characteristic behavioural traits associated with vestibular defects including headbobbing, circling and deafness. This mutation was caused by the insertion of a transgene into distal chromosome
Externí odkaz:
https://doaj.org/article/8c63d1aab8a343f39d05222242db5f9f
Autor:
Nicholas Parkinson, Rachel E Hardisty-Hughes, Hilda Tateossian, Hsun-Tien Tsai, Debra Brooker, Sue Morse, Zuzanna Lalane, Francesca MacKenzie, Martin Fray, Pete Glenister, Anne-Marie Woodward, Sian Polley, Ivana Barbaric, Neil Dear, Tertius A Hough, A Jackie Hunter, Michael T Cheeseman, Steve D M Brown
Publikováno v:
PLoS Genetics, Vol 2, Iss 10, p e149 (2006)
Otitis media (OM), inflammation of the middle ear, remains the most common cause of hearing impairment in children. It is also the most common cause of surgery in children in the developed world. There is evidence from studies of the human population
Externí odkaz:
https://doaj.org/article/4e04b3f64b7f43c8b014fa9eef6c1a5c
Autor:
Susan Morse, Elizabeth Smart, Robert E MacLaren, Sara Wells, Alun R. Barnard, Michael R. Bowl, Lauren Chessum, Andrew Parker, Stuart L. Johnson, Rachel E. Hardisty-Hughes, Walter Marcotti, Joanne Dorning, Melissa West, Carlos Aguilar, Leanne Carrott, Steve D. M. Brown, Greg Ball
Publikováno v:
The Journal of Neuroscience. 36:222-234
TheNeuroplastingene encodes two synapse-enriched protein isoforms, Np55 and Np65, which are transmembrane glycoproteins that regulate several cellular processes, including the genesis, maintenance, and plasticity of synapses. We found that an absence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3744a834d97c7a6eb5340234d893184
https://doi.org/10.1523/jneurosci.1808-15.2016
https://doi.org/10.1523/jneurosci.1808-15.2016
Autor:
Andrew Parker, Sara Wells, Debbie Williams, Michael Crompton, Mahmood F. Bhutta, Richard O. Gale, Tom Purnell, Hilda Tateossian, Hayley E. Tyrer, Rachel E. Hardisty-Hughes, Steve D.M. Brown, Martin J. Burton, Michelle Simon, Charlotte H. Dean, Greg Ball, Ann-Marie Mallon
Publikováno v:
PLoS Genetics, Vol 13, Iss 8, p e1006969 (2017)
PLoS Genetics
PLoS Genetics
Otitis media (OM), inflammation of the middle ear (ME), is a common cause of conductive hearing impairment. Despite the importance of the disease, the aetiology of chronic and recurrent forms of middle ear inflammatory disease remains poorly understo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe5311f9a4ff5c38ce08905b3338cf3f
http://hdl.handle.net/10044/1/52030
http://hdl.handle.net/10044/1/52030
Publikováno v:
Nature Protocols. 5:177-190
We describe a protocol for the production of mice carrying N-ethyl-N-nitrosourea (ENU) mutations and their screening for auditory and vestibular phenotypes. In comparison with the procedures describing individual phenotyping tests, this protocol inte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41fbce8fd7105f82c800ee4b85da81b4
https://doi.org/10.1038/nprot.2009.204
https://doi.org/10.1038/nprot.2009.204
Publikováno v:
Nature Reviews Genetics. 9:277-290
Mouse genetics has made crucial contributions to the understanding of the molecular mechanisms of hearing. With the help of a plethora of mouse mutants, many of the key genes that are involved in the development and functioning of the auditory system
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28c9a9d4a8277cfbc9aac3eb8cfd604c
https://doi.org/10.1038/nrg2309
https://doi.org/10.1038/nrg2309
Autor:
Susan Morse, Michael R. Bowl, George Nicholson, Emma L. Coghill, Steve D.M. Brown, Ian J. Jackson, Rachel E. Hardisty-Hughes, Sally H. Cross, Andrew Parker
Publikováno v:
Disease Models & Mechanisms.
The Mitogen-Activated Protein kinase, MAP3K1, plays an important role in a number of cellular processes, including epithelial migration during eye organogenesis. In addition, studies in keratinocytes indicate that MAP3K1 signaling through JNK is impo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d153dc7231c97542b87bbb92a8400ff3
https://doi.org/10.1242/dmm.023176
https://doi.org/10.1242/dmm.023176
Autor:
Alice Middleton, Susan Morse, Rachel E. Hardisty-Hughes, Hilda Tateossian, A. Jackie Hunter, M. Rosario Romero, Michael Cheeseman, Zuzanna Tymowska-Lalanne, Steve D.M. Brown
Publikováno v:
Human Molecular Genetics. 15:3273-3279
Otitis media (OM), inflammation of the middle ear, is the most common cause of hearing impairment and surgery in children. Recurrent and chronic forms of OM are known to have a strong genetic component, but nothing is known of the underlying genes in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b2ef5796dbe518f7076d413e44f5462
https://doi.org/10.1093/hmg/ddl403
https://doi.org/10.1093/hmg/ddl403
Publikováno v:
Brain Research. 1091:9-15
The pathogenesis of otitis media (OM) is multifactorial and includes infection, anatomical factors, immunologic status, genetic predisposition, and environmental factors. OM remains the most common cause of hearing impairment in childhood. Genetic pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2b6102bee04e326cce76c621288c0fe
https://doi.org/10.1016/j.brainres.2006.01.046
https://doi.org/10.1016/j.brainres.2006.01.046