Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Rachel E. Geroux"'
Autor:
Andrea Stojakovic, Sergey Trushin, Anthony Sheu, Layla Khalili, Su-Youne Chang, Xing Li, Trace Christensen, Jeffrey L. Salisbury, Rachel E. Geroux, Benjamin Gateno, Padraig J. Flannery, Mrunal Dehankar, Cory C. Funk, Jordan Wilkins, Anna Stepanova, Tara O’Hagan, Alexander Galkin, Jarred Nesbitt, Xiujuan Zhu, Utkarsh Tripathi, Slobodan Macura, Tamar Tchkonia, Tamar Pirtskhalava, James L. Kirkland, Rachel A. Kudgus, Renee A. Schoon, Joel M. Reid, Yu Yamazaki, Takahisa Kanekiyo, Song Zhang, Emirhan Nemutlu, Petras Dzeja, Adam Jaspersen, Ye In Christopher Kwon, Michael K. Lee, Eugenia Trushina
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-9 (2024)
Externí odkaz:
https://doaj.org/article/67f438cf2e6642df8392e5f12d364395
Autor:
Andrea Stojakovic, Sergey Trushin, Anthony Sheu, Layla Khalili, Su-Youne Chang, Xing Li, Trace Christensen, Jeffrey L. Salisbury, Rachel E. Geroux, Benjamin Gateno, Padraig J. Flannery, Mrunal Dehankar, Cory C. Funk, Jordan Wilkins, Anna Stepanova, Tara O’Hagan, Alexander Galkin, Jarred Nesbitt, Xiujuan Zhu, Utkarsh Tripathi, Slobodan Macura, Tamar Tchkonia, Tamar Pirtskhalava, James L. Kirkland, Rachel A. Kudgus, Renee A. Schoon, Joel M. Reid, Yu Yamazaki, Takahisa Kanekiyo, Song Zhang, Emirhan Nemutlu, Petras Dzeja, Adam Jaspersen, Ye In Christopher Kwon, Michael K. Lee, Eugenia Trushina
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-20 (2021)
Abstract Alzheimer’s Disease (AD) is a devastating neurodegenerative disorder without a cure. Here we show that mitochondrial respiratory chain complex I is an important small molecule druggable target in AD. Partial inhibition of complex I trigger
Externí odkaz:
https://doaj.org/article/2dbe29f2b76b4e27b72c8ee1c521260b
Autor:
Liang Zhang, Sergey Trushin, Trace A. Christensen, Utkarsh Tripathi, Courtney Hong, Rachel E. Geroux, Kyle G. Howell, Joseph F. Poduslo, Eugenia Trushina
Publikováno v:
Neurobiology of Disease, Vol 114, Iss , Pp 1-16 (2018)
Inhibition of mitochondrial axonal trafficking by amyloid beta (Aβ) peptides has been implicated in early pathophysiology of Alzheimer's Disease (AD). Yet, it remains unclear whether the loss of motility inevitably induces the loss of mitochondrial
Externí odkaz:
https://doaj.org/article/52f1554e86a742b5b3c0ff9f6e53d363
Autor:
Antentor Hinton, Prasanna Katti, Trace A. Christensen, Margaret Mungai, Jianqiang Shao, Liang Zhang, Sergey Trushin, Ahmad Alghanem, Adam Jaspersen, Rachel E. Geroux, Kit Neikirk, Michelle Biete, Edgar Garza Lopez, Bryanna Shao, Zer Vue, Larry Vang, Heather K. Beasley, Andrea G. Marshall, Dominique Stephens, Steven Damo, Jessica Ponce, Christopher K. E. Bleck, Innes Hicsasmaz, Sandra A. Murray, Ranthony A. C. Edmonds, Andres Dajles, Young Do Koo, Serif Bacevac, Jeffrey L. Salisbury, Renata O. Pereira, Brian Glancy, Eugenia Trushina, E. Dale Abel
Publikováno v:
Advanced Biology.
Autor:
Dajles A, Antentor Hinton, Zer Vue, Bacevac S, Kit Neikirk, Ahmad F. Alghanem, Abel Ed, Eugenia Trushina, Andrea G. Marshall, Garza Lopez E, Jianqiang Shao, Adam Jaspersen, Edmonds Ra, Renata O. Pereira, Liang Zhang, Hicsasmaz I, Prasanna Katti, Sergey Trushin, Brian Glancy, Jeffrey L. Salisbury, Heather K. Beasley, Trace A. Christensen, Mungai M, Young Do Koo, Rachel E. Geroux, Michelle Biete
SummaryMitochondrial dynamics (fission, fusion, and the formation of nanotunnels) and morphology are very sensitive to the cellular environment. Mitochondria may be adversely affected by oxidative stress, changes in calcium levels, and hypoxia. Inves
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a94b4f98f4de2f08ad3b3fed2345bd09
https://doi.org/10.1101/2021.06.27.450055
https://doi.org/10.1101/2021.06.27.450055
Autor:
Benjamin Gateno, Tara O’Hagan, Michael K. Lee, Xiujuan Zhu, Yu Yamazaki, Joel M. Reid, Andrea Stojakovic, Takahisa Kanekiyo, Su-Youne Chang, Song Zhang, Renee A. Schoon, Tamar Pirtskhalava, Rachel E. Geroux, Xing Li, Ye In Christopher Kwon, Trace A. Christensen, Eugenia Trushina, Jeffrey L. Salisbury, Slobodan Macura, Cory C. Funk, Mrunal Dehankar, James L. Kirkland, Petras P. Dzeja, Utkarsh Tripathi, Jarred J. Nesbitt, Adam Jaspersen, Tamar Tchkonia, Padraig J. Flannery, Sergey Trushin, Emirhan Nemutlu, Jordan Wilkins, Alexander Galkin, Anna Stepanova, Anthony Sheu, Layla Khalili, Rachel A. Kudgus
Publikováno v:
Communications Biology
Communications Biology, Vol 4, Iss 1, Pp 1-20 (2021)
Communications Biology, Vol 4, Iss 1, Pp 1-20 (2021)
Alzheimer’s Disease (AD) is a devastating neurodegenerative disorder without a cure. Here we show that mitochondrial respiratory chain complex I is an important small molecule druggable target in AD. Partial inhibition of complex I triggers the AMP
Autor:
Setri Fugar, Khrystyna Deka, Christina Anderson, Claudia Lama von Buchwald, Rachel E. Geroux, Maria S. Gerges, Jennifer White, Fareed Moses S. Collado, Hussam Suradi, Clifford J. Kavinsky
Publikováno v:
Journal of the Society for Cardiovascular Angiography & Interventions. 1:100184
Autor:
Tamar Pirtskhalava, Trace A. Christensen, Emirhan Nemutlu, Mrunal Dehankar, Utkarsh Tripathi, Adam Jaspersen, Anthony Sheu, Sergey Trushin, Eugenia Trushina, Tamar Tchkonia, Christopher Ye In Kwon, Su-Youne Chang, Song Zhang, James L. Kirkland, Xing Li, Xiujuan Zhu, Slobodan Macura, Jordan Wilkins, Layla Khalili, Rachel A. Kudgus, Andrea Stojakovic, Jeffrey L. Salisbury, Alexander Galkin, Jarred J. Nesbitt, Petras P. Dzeja, Padraig J. Flannery, Joel M. Reid, Renee A. Schoon, Takahisa Kanekiyo, Anna Stepanova, Tara O’Hagan, Michael K. Lee, Yu Yamazaki, Rachel E. Geroux, Cory C. Funk, Benjamin Gateno
We demonstrate that mitochondrial respiratory chain complex I is an important small molecule druggable target in Alzheimer’s Disease (AD). Partial inhibition of complex I triggers the AMP-activated protein kinase-dependent signaling network leading
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9277825fbc16e4b867cbddafb5528dbf
https://doi.org/10.1101/2020.07.01.182428
https://doi.org/10.1101/2020.07.01.182428
Autor:
Trace A. Christensen, Utkarsh Tripathi, Eugenia Trushina, Kyle G. Howell, Joseph F. Poduslo, Liang Zhang, Courtney Hong, Rachel E. Geroux, Sergey Trushin
Publikováno v:
Neurobiology of Disease, Vol 114, Iss, Pp 1-16 (2018)
Inhibition of mitochondrial axonal trafficking by amyloid beta (Aβ) peptides has been implicated in early pathophysiology of Alzheimer's Disease (AD). Yet, it remains unclear whether the loss of motility inevitably induces the loss of mitochondrial