Modulation of Wnt Signaling Enhances Inner Ear Organoid Development in 3D Culture.

Autor: Rachel E DeJonge, Xiao-Ping Liu, Christopher R Deig, Stefan Heller, Karl R Koehler, Eri Hashino

Publikováno v: PLoS ONE, Vol 11, Iss 9, p e0162508 (2016)

Stem cell-derived inner ear sensory epithelia are a promising source of tissues for treating patients with hearing loss and dizziness. We recently demonstrated how to generate inner ear sensory epithelia, designated as inner ear organoids, from mouse

Externí odkaz: https://doaj.org/article/623e3eef17544796a210d64cb077c4dc

Intrastriatal Transplantation of Adenovirus-Generated Induced Pluripotent Stem Cells for Treating Neuropathological and Functional Deficits in a Rodent Model of Huntington's Disease

Autor: Rachel E. DeJonge, Laurent Lescaudron, Gary L. Dunbar, Ming Lu, Aaron Antcliff, Allison C. Moore, Xavier Lévêque, Lucas D. Huffman, Andrew T. Crane, Darren Story, Dylan J. Dues, Julien Rossignol, Phillip A. Starski, Kyle D. Fink

Publikováno v: Stem Cells Translational Medicine
Stem Cells Translational Medicine, Wiley, 2014, 3 (5), pp.620-631. ⟨10.5966/sctm.2013-0151⟩
Stem cells translational medicine, vol 3, iss 5
Stem Cells Translational Medicine, 2014, 3 (5), pp.620-631. ⟨10.5966/sctm.2013-0151⟩

Induced pluripotent stem cells (iPSCs) show considerable promise for cell replacement therapies for Huntington's disease (HD). Our laboratory has demonstrated that tail-tip fibroblasts, reprogrammed into iPSCs via two adenoviruses, can survive and di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::387d590c1a67f027ba98c6595c80084c
https://www.hal.inserm.fr/inserm-01847320/document