Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Rachel E. Ashley"'
Autor:
Sylvia A. McPherson, Rachel E. Ashley, Charles L. Turnbough, Neil Osheroff, Keir C. Neuman, Andrew Dittmore
Publikováno v:
Nucleic Acids Research
Although bacterial gyrase and topoisomerase IV have critical interactions with positively supercoiled DNA, little is known about the actions of these enzymes on overwound substrates. Therefore, the abilities of Bacillus anthracis and Escherichia coli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10bb76d4f3fa145239a11c8cb0ae0790
https://doi.org/10.1093/nar/gkx649
https://doi.org/10.1093/nar/gkx649
Autor:
Neil Osheroff, Rachel E. Ashley
Publikováno v:
Knots, Low-Dimensional Topology and Applications ISBN: 9783030160302
Although the genetic information is encoded in a one-dimensional array of nucleic acid bases, three-dimensional relationships within DNA play a major role in how this information is accessed and utilized by living organisms. Because of the intertwine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::509000a0daffc74f37270565dae660df
https://doi.org/10.1007/978-3-030-16031-9_20
https://doi.org/10.1007/978-3-030-16031-9_20
Publikováno v:
Chemical Research in Toxicology. 28:989-996
Extracts from the rhizome of the turmeric plant are widely consumed as anti-inflammatory dietary supplements. Turmeric extract contains the three curcuminoids, curcumin (≈80% relative abundance), demethoxycurcumin (DMC; ≈15%), and bisdemethoxycur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c90c87a101cf38ee38e6578f94cb3c4
https://doi.org/10.1021/acs.chemrestox.5b00009
https://doi.org/10.1021/acs.chemrestox.5b00009
Publikováno v:
Antimicrobial Resistance in the 21st Century ISBN: 9783319785370
Fluoroquinolones are one of the most widely prescribed classes of broad-spectrum antibacterials currently in clinical use. These drugs kill bacteria by increasing DNA strand breaks generated by the type II topoisomerases, gyrase and topoisomerase IV.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a36e799c65b14fabe0331d35cb4eeb3f
https://doi.org/10.1007/978-3-319-78538-7_16
https://doi.org/10.1007/978-3-319-78538-7_16
Publikováno v:
Biochemistry
Biochemistry, 2017, Vol.56(40), pp.5440-5448 [Peer Reviewed Journal]
Biochemistry, 2017, Vol.56(40), pp.5440-5448 [Peer Reviewed Journal]
Mycobacterium tuberculosis encodes only a single type II topoisomerase, gyrase. As a result, this enzyme likely carries out the cellular functions normally performed by canonical gyrase and topoisomerase IV, both in front of and behind the replicatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1699f6e4f1cb482d8ab77f889524859e
https://pubmed.ncbi.nlm.nih.gov/28921956
https://pubmed.ncbi.nlm.nih.gov/28921956
Autor:
Sylvia A. McPherson, R. Hunter Lindsey, Rachel E. Ashley, Robert J. Kerns, Neil Osheroff, Charles L. Turnbough
Publikováno v:
Biochemistry
Gyrase appears to be the primary cellular target for quinolone antibacterials in multiple pathogenic bacteria, including Bacillus anthracis, the causative agent of anthrax. Given the significance of this type II topoisomerase as a drug target, it is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2d46c4a0cc512383a959c70c6a5adbd
https://pubmed.ncbi.nlm.nih.gov/28708938
https://pubmed.ncbi.nlm.nih.gov/28708938
Autor:
Joseph E. Deweese, Rachel E. Ashley, MaryJean Pendleton, Susan L. Mercer, R. Hunter Lindsey, Neil Osheroff
Publikováno v:
Biochemistry
Coordination between the N-terminal gate and the catalytic core of topoisomerase II allows the proper capture, cleavage, and transport of DNA during the catalytic cycle. Because the activities of these domains are tightly linked, it has been difficul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dc0b7143d5d0ffc73c8903749084727
https://pubmed.ncbi.nlm.nih.gov/25280269
https://pubmed.ncbi.nlm.nih.gov/25280269
Autor:
Tracy L. Johnson Salyard, Neil Osheroff, Steven L. Pitts, Jeannie Stubblefield, Anuradha Liyana Pathiranage, Norma K. Dunlap, Rachel E. Ashley
Publikováno v:
Bioorganicmedicinal chemistry letters. 24(24)
A series of novel ether-linked dimers of demethylepipodophyllotoxin are topoisomerase II poisons that exhibit higher levels of double-stranded versus single-stranded DNA cleavage than their corresponding monomers. The dimers also have higher levels o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::815ba40e377c3c893af62daf1f86bddc
https://pubmed.ncbi.nlm.nih.gov/25466187
https://pubmed.ncbi.nlm.nih.gov/25466187
Autor:
Rachel E. Ashley, Neil Osheroff
Publikováno v:
Chemical Research in Toxicology
The seeds of Nigella sativa (often referred to as black seed) have long been utilized as a medicinal herb in Middle Eastern, Northern African, and Indian cultures. Historically, black seed has been used to treat a variety of illnesses associated with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9504ae7ab7bd898fcd3a7bb4bebc82ab
https://pubmed.ncbi.nlm.nih.gov/24650156
https://pubmed.ncbi.nlm.nih.gov/24650156
Publikováno v:
Chemical Research in Toxicology; May2015, Vol. 28 Issue 5, p989-996, 8p