Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Rachel E Woolley"'
Autor:
Tomas Malinauskas, Gareth Moore, Amalie F. Rudolf, Holly Eggington, Hayley L. Belnoue-Davis, Kamel El Omari, Samuel C. Griffiths, Rachel E. Woolley, Ramona Duman, Armin Wagner, Simon J. Leedham, Clair Baldock, Hilary L. Ashe, Christian Siebold
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Twisted gastrulation (TWSG1) is an evolutionarily conserved secreted glycoprotein which controls signaling by Bone Morphogenetic Proteins (BMPs). TWSG1 binds BMPs and their antagonist Chordin to control BMP signaling during embryonic develop
Externí odkaz:
https://doaj.org/article/ddfaa798787944ee8ae8169dabd72ec6
Autor:
Maia Kinnebrew, Rachel E. Woolley, T. Bertie Ansell, Eamon F. X. Byrne, Sara Frigui, Giovanni Luchetti, Ria Sircar, Sigrid Nachtergaele, Laurel Mydock-McGrane, Kathiresan Krishnan, Simon Newstead, Mark S. P. Sansom, Douglas F. Covey, Christian Siebold, Rajat Rohatgi
Publikováno v:
Science Advances. 8
Smoothened (SMO) transduces the Hedgehog (Hh) signal across the plasma membrane in response to accessible cholesterol. Cholesterol binds SMO at two sites: one in the extracellular cysteine-rich domain (CRD) and a second in the transmembrane domain (T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cecbac756ffd5793e4e4f0b3695b007b
https://doi.org/10.1126/sciadv.abm5563
https://doi.org/10.1126/sciadv.abm5563
Autor:
Jean M. H. van den Elsen, Hannah B. L. Jones, Omar Kassaar, Michael J Knight, Christina E. Gulácsy, Andrew G. Watts, Rachel E Woolley, Stephen A. Wells, Stuart Parsons, Elizabeth Rodriguez, Polly Phaal, Andreia Marques, Anthony Kwok, Alison Turner, John O'Hara, Christopher R. Pudney, Leo A Bowsher, Kieran Dawkins
Publikováno v:
Biochemical Journal
Among the major challenges in the development of biopharmaceuticals are structural heterogeneity and aggregation. The development of a successful therapeutic monoclonal antibody (mAb) requires both a highly active and also stable molecule. Whilst a r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53b7492f844b31e06c9240ca54a3446f
https://doi.org/10.1042/bcj20200580
https://doi.org/10.1042/bcj20200580
Publikováno v:
Current Opinion in Structural Biology
The Hedgehog (HH) signalling pathway is a cell–cell communication system that controls the patterning of multiple tissues during embryogenesis in metazoans. In adults, HH signals regulate tissue stem cells and regenerative responses. Abnormal signa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9e8205cc127129a4af6266106f6d14f
Autor:
Paul J Neeson, Dale I. Godfrey, Andrew N. Keller, Jamie Rossjohn, Rachel E. Woolley, Adam P Uldrich, John N. Waddington, Jérôme Le Nours, David Ritchie, James McCluskey, David P. Fairlie, Daniel G. Pellicci, Richard W Birkinshaw, Nicholas A Gherardin, Ligong Liu, Sidonia B G Eckle
Publikováno v:
Immunity. 44(1)
A characteristic of mucosal-associated invariant T (MAIT) cells is the expression of TRAV1-2(+) T cell receptors (TCRs) that are activated by riboflavin metabolite-based antigens (Ag) presented by the MHC-I related molecule, MR1. Whether the MR1-rest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe02825539dd74ecbef7b464b64fe24e
https://pubmed.ncbi.nlm.nih.gov/26795251
https://pubmed.ncbi.nlm.nih.gov/26795251