Výsledky vyhledávání - "Rachel E Thomas"

Akademický článek

Spontaneous liver disease in wild-type C57BL/6JOlaHsd mice fed semisynthetic diet.

Autor: Onne A H O Ronda, Bert J M van de Heijning, Alain de Bruin, Rachel E Thomas, Ingrid Martini, Martijn Koehorst, Albert Gerding, Mirjam H Koster, Vincent W Bloks, Angelika Jurdzinski, Niels L Mulder, Rick Havinga, Eline M van der Beek, Dirk-Jan Reijngoud, Folkert Kuipers, Henkjan J Verkade

Publikováno v: PLoS ONE, Vol 15, Iss 9, p e0232069 (2020)

Mouse models are frequently used to study mechanisms of human diseases. Recently, we observed a spontaneous bimodal variation in liver weight in C57BL/6JOlaHsd mice fed a semisynthetic diet. We now characterized the spontaneous variation in liver wei

Externí odkaz: https://doaj.org/article/7a34a45721614e4783dbcd572ecf0fb3

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Autor: Wenxuan Zhang, Rachel E. Thomas, Johan W. Jonker, Justina C. Wolters, Fentaw Abegaz, Janine K. Kruit, Ronald van Os, Marleen B Dommerholt, Barbara M. Bakker, Dirk-Jan Reijngoud, Maaike Blankestijn, Ydwine T. van der Veen, Marcel A. Vieira-Lara, Albert Gerding

Publikováno v: BMC Biology, Vol 19, Iss 1, Pp 1-18 (2021)
BMC Biology, 19(1):154. BioMed Central Ltd.
BMC Biology
Vieira-Lara, M A, Dommerholt, M B, Zhang, W, Blankestijn, M, Wolters, J C, Abegaz, F, Gerding, A, van der Veen, Y T, Thomas, R, van Os, R P, Reijngoud, D J, Jonker, J W, Kruit, J K & Bakker, B M 2021, ' Age-related susceptibility to insulin resistance arises from a combination of CPT1B decline and lipid overload ', BMC Biology, vol. 19, no. 1, 154 . https://doi.org/10.1186/s12915-021-01082-5

Background The skeletal muscle plays a central role in glucose homeostasis through the uptake of glucose from the extracellular medium in response to insulin. A number of factors are known to disrupt the normal response to insulin leading to the emer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5588b5270296379509163fcde869ad4
https://doaj.org/article/a9716da0b74d420cb0e3c1ac024d69e9

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Hepatic Carbohydrate Response Element Binding Protein Activation Limits Nonalcoholic Fatty Liver Disease Development in a Mouse Model for Glycogen Storage Disease Type 1a

Autor: Justina C. Wolters, Michel van Weeghel, Gilles Mithieux, Aycha Bleeker, Folkert Kuipers, Vincent W. Bloks, Fabienne Rajas, Yu Lei, Joanne A Hoogerland, Henk Wolters, Maaike H. Oosterveer, Trijnie Bos, Alain de Bruin, Brenda S. Hijmans, Rachel E. Thomas, Theo H. van Dijk, Riekelt H. Houtkooper

Publikováno v: Hepatology (Baltimore, Md.)
Hepatology
Hepatology, Wiley-Blackwell, 2020, 72 (5), pp.1638-1653. ⟨10.1002/hep.31198⟩
Hepatology (Baltimore, Md.), 72(5), 1638-1653. John Wiley and Sons Ltd

International audience; Background and aims: Glycogen storage disease (GSD) type 1a is an inborn error of metabolism caused by defective glucose-6-phosphatase catalytic subunit (G6PC) activity. Patients with GSD 1a exhibit severe hepatomegaly due to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fef552596e2f74f7d1302480c5bc2586
http://europepmc.org/articles/PMC7702155

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Cordless ultrasonic dissector versus advanced bipolar vessel sealing device for laparoscopic ovariectomy in dogs*

Autor: Jolle Kirpensteijn, Rachel E. Thomas, Sebastiaan A. van Nimwegen, Sara S. D. S. Janssens, Anneleen L. Spillebeen

Publikováno v: Veterinary Surgery. 46:467-477

Objective To compare Sonicision cordless ultrasonic dissector (SCUD) to LigaSure vessel sealing device (LVSD) for laparoscopic ovariectomy (Lap OVE) in dogs. Study design Randomized, paired prospective clinical trial. Animals Client-owned dogs (n = 2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4c78ea679a46f4dc38fe05141e5f7ab7
https://doi.org/10.1111/vsu.12640

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Gastric carcinoma in canines and humans, a review

Autor: Alexander J. German, Paul J J Mandigers, Iwan Burgener, Rachel E. Thomas, S. Hugen

Publikováno v: Veterinary and Comparative Oncology. 15:692-705

Gastric carcinoma (GC) is the most common neoplasm in the stomach of dogs. Although incidence in the general population is reported to be low, breed-specific GC has a high incidence. Median age at presentation ranges from 8 to approximately 10 years.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::464b651e89cc1fe2ad1acf316b02bfec
https://doi.org/10.1111/vco.12249

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Atypical E2Fs inhibit tumor angiogenesis

Autor: Bart Westendorp, Stefan Schulte-Merker, M Zijp, W J Bakker, B T Hien, Bart Weijts, Rachel E. Thomas, L M Martínez-López, A. de Bruin, Ingrid Thurlings

Publikováno v: Oncogene, 37, 271. Nature Publishing Group
ONCOGENE, 37(2), 271-276. Nature Publishing Group
Oncogene, 37(2), 271-276. Nature Publishing Group
Oncogene, 37(2), 271. Nature Publishing Group
Oncogene

Atypical E2F transcription factors (E2F7 and E2F8) function as key regulators of cell cycle progression and their inactivation leads to spontaneous cancer formation in mice. However, the mechanism of the tumor suppressor functions of E2F7/8 remain ob

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::365844f8d9941687f94eb1d86431a330
https://dspace.library.uu.nl/handle/1874/388249

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The Wnt pathway, epithelial-stromal interactions, and malignant progression in phyllodes tumours

Autor: Rachel E. Thomas, Andrew M. Hanby, Cheryl Gillett, Elinor J. Sawyer, Andrew Rowan, Richard Poulsom, Sunil R. Lakhani, Ian Tomlinson, Paul Ellis, Ian O. Ellis

In a previous study of phyllodes tumours, it has been shown that both the stroma and the epithelium can exhibit distinct molecular changes, suggesting that both are part of the neoplastic process. In view of this finding, it was decided to study stro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20cd3fad385ee7d7361b836f2fb1a407
https://ora.ox.ac.uk/objects/uuid:1f344794-319f-4006-a487-d5140fd0e9b6

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Cordless ultrasonic dissector versus advanced bipolar vessel sealing device for laparoscopic ovariectomy in dogs

Autor: Anneleen L, Spillebeen, Sara S D S, Janssens, Rachel E, Thomas, Jolle, Kirpensteijn, Sebastiaan A, van Nimwegen

Publikováno v: Veterinary surgery : VS. 46(4)

To compare Sonicision cordless ultrasonic dissector (SCUD) to LigaSure vessel sealing device (LVSD) for laparoscopic ovariectomy (Lap OVE) in dogs.Randomized, paired prospective clinical trial.Client-owned dogs (n = 22) presented for elective Lap OVE

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::27efea6ac97534e5302a00db4dda4bd3
https://pubmed.ncbi.nlm.nih.gov/28314072

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Evaluation of group versus individual physiotherapy following lower limb intra-muscular Botulinum Toxin-Type A injections for ambulant children with cerebral palsy: A single-blind randomized comparison trial

Autor: Megan Kentish, Leanne Sakzewski, Leanne M Johnston, Rachel E. Thomas, Roslyn N. Boyd

Publikováno v: Research in developmental disabilities.

This study aimed to evaluate efficacy of group (GRP) versus individual (IND) physiotherapy rehabilitation following lower limb intramuscular injections of Botulinum Toxin-Type A (BoNT-A) for ambulant children with cerebral palsy (CP). Following lower

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d72fa9be55131010dc04b484848da9f1
https://pubmed.ncbi.nlm.nih.gov/26955912

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