Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Rachel E Sutherland"'
Publikováno v:
PLoS ONE, Vol 6, Iss 11, p e27564 (2011)
Mammals are serially infected with a variety of microorganisms, including bacteria and parasites. Each infection reprograms the immune system's responses to re-exposure and potentially alters responses to first-time infection by different microorgani
Externí odkaz:
https://doaj.org/article/6529f34e57034673a0907a340c66d092
Autor:
Cecilia Marmai, Kevin K. Kim, Paul J. Wolters, Xiaohui Fang, Rachel E. Sutherland, J.A. Golden, Gregory Dolganov, Charles W. Hoopes, Michael A. Matthay, Sophia S. Kim, Harold A. Chapman, Shuwei Jiang
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 301:L71-L78
Prior work has shown that transforming growth factor-β (TGF-β) can mediate transition of alveolar type II cells into mesenchymal cells in mice. Evidence this occurs in humans is limited to immunohistochemical studies colocalizing epithelial and mes
Autor:
Jon Koff, Paul J. Wolters, James A. Frank, Sophia S. Kim, Ying Mao, Charlie M Wray, Rachel E. Sutherland
Publikováno v:
The Journal of Immunology. 182:8056-8062
IL-6 is a biological marker of ventilator-associated lung injury that may contribute to alveolar barrier dysfunction in acute respiratory distress syndrome. To determine whether IL-6 affects alveolar barrier disruption in a model of ventilator-induce
Autor:
Francis Gauthier, Cécile Chupin, Géraldine Rios, Nicolas Pottier, Virginie Defamie, Bruno Cardinaud, Paul J. Wolters, Pascal Barbry, Yves Berthiaume, Bernard Mari, Rachel E. Sutherland
Publikováno v:
American Journal of Respiratory and Critical Care Medicine
American Journal of Respiratory and Critical Care Medicine, American Thoracic Society, 2007, 176 (11), pp.1098-107. ⟨10.1164/rccm.200607-1051OC⟩
American Journal of Respiratory and Critical Care Medicine, American Thoracic Society, 2007, 176 (11), pp.1098-107. ⟨10.1164/rccm.200607-1051OC⟩
RATIONALE: Different sensitivities to profibrotic compounds such as bleomycin are observed among mouse strains. OBJECTIVES: To identify genetic factors contributing to the outcome of lung injury. METHODS: Physiological comparison of C57BL/6 (sensitiv
Autor:
Sophia S. Kim, Brenda Salantes, Rachel E. Sutherland, Paul J. Wolters, Joanna S. Olsen, George H. Caughey
Publikováno v:
Biochemical and biophysical research communications. 450(1)
Prior work established that a deficiency in the cysteine protease dipeptidyl peptidase I (DPPI) improves survival following polymicrobial septic peritonitis. To test whether DPPI regulates survival from severe lung infections, DPPI(-/-) mice were stu
Systemic mast cell degranulation increases mortality during polymicrobial septic peritonitis in mice
MCs are required for an effective host response during septic peritonitis. Local MC degranulation facilitates neutrophil recruitment, activation, and bacterial killing. However, the role of MCs located distant from the site of infection is unknown. W
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1768708ca9e658f3627a1a3df18cc63
https://europepmc.org/articles/PMC3157900/
https://europepmc.org/articles/PMC3157900/
Mast Cells Degranulate In Tissues Distant To The Primary Site Of Infection During Septic Peritonitis
Publikováno v:
A37. ROLE OF MAST CELLS IN LUNG DISEASE.
Publikováno v:
C68. ALVEOLAR EPITHELIUM.
Autor:
S. Armando Villalta, Paul J. Wolters, Rachel E. Sutherland, Andrew McKinstry, Joanna S. Olsen
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 181(8)
The pleiotropic cytokine IL-6 has favorable and harmful effects on survival from bacterial infections. Although many innate immune cells produce IL-6, little is known about relevant sources in vivo and the nature of its contributions to host response
Autor:
Jon Mallen-St. Clair, Harold A. Chapman, Paul J. Wolters, Rachel E. Sutherland, Guo-Ping Shi, George H. Caughey
Publikováno v:
Biological Chemistry. 387
The cysteine protease dipeptidyl peptidase I (DPPI) activates granule-associated immune-cell serine proteases. The in vivo activator of DPPI itself is unknown; however, cathepsins L and S are candidates because they activate pro-DPPI in vitro. In thi