Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Rachel E, Ibbotson"'
Autor:
Anton Parker, Gordon Strathdee, Rachel E. Ibbotson, Laura Irving, David Oscier, Tryfonia Mainou-Fowler
Publikováno v:
Epigenetics. 6:300-306
Chronic lymphocytic leukemia (CLL) exhibits a highly variable clinical course. Altered DNA methylation of genes has shown promise as a source of novel prognostic makers in a number of cancers. Here we have studied the potential utility of a panel of
Autor:
Renata Walewska, Anne Gardiner, Oliver Giles Best, Aneela Majid, David Oscier, Tatjana Stankovic, Rachel E. Ibbotson, Martin J. S. Dyer, Anna Skowronska, Belinda Austen
Publikováno v:
Leukemia. 22:1456-1459
A novel functional assay using etoposide plus nutlin-3a detects and distinguishes between ATM and TP53 mutations in CLL
Autor:
Françoise Berger, Ralf Küppers, José I. Martín-Subero, Wolfram Klapper, Evelyne Callet-Bauchu, Randy D. Gascoyne, Hans-Heinrich Wacker, Martin J. S. Dyer, Michael Kneba, Pascale Felman, C De Wolf-Peeters, Douglas E. Horsman, Anne Gardiner, Aneela Majid, Matthias Ritgen, Iwona Wlodarska, N. Parry-Jones, G. Thiel, Lana Harder, S Gesk, Lucienne Michaux, Marta Salido, Reiner Siebert, Rachel E. Ibbotson, David Oscier, Maria-Jose Calasanz, Francesc Sole
Publikováno v:
Leukemia. 21:1532-1544
The biologic and pathologic features of B-cell malignancies bearing a translocation t(14;19)(q32;q13) leading to a fusion of IGH and BCL3 are still poorly described. Herein we report the results of a comprehensive cytogenetic, fluorescence in situ hy
Autor:
Martin Corcoran, Olle Sangfelt, Mikael Lerner, Dan Grandér, Marianne Hammarsund, Lars Forsberg, Chaoyong Zhu, Rachel E. Ibbotson, Kapanadze Bi, Stefan Einhorn, Catharina Larsson, David Oscier, Bill Wilson
Publikováno v:
Genes, Chromosomes and Cancer. 40:285-297
Our group previously identified two novel genes, RFP2/LEU5 and DLEU2, within a 13q14.3 genomic region of loss seen in various malignancies. However, no specific inactivating mutations were found in these or other genes in the vicinity of the deletion
Autor:
Anna Pestova, Rachel E. Ibbotson, Ancha Baranova, Francesco Gorreta, N. V. Makeeva, Stefan Einhorn, Marianne Hammarsund, Tariq Alsheddi, Martin Corcoran, Dmitry A. Shagin, Eugene R. Zabarovsky, T. V. Tyazhelova, Nikitin Ea, Andrey Ivanovich Vorobiev, Dmitry Ivanov, Kapanadze Bi, Mikhail Skoblov, N. K. Yankovsky, Karen Schlauch, Olle Sangfelt, Tatiana Borodina, Vikas Chandhoke, A. B. Poltaraus, Dan Grandér, Svetlana Nazarenko, David Oscier, Sergey Lukianov
Publikováno v:
Gene. 321:103-112
In the present study, we describe the human and mouse RFP2 gene structure, multiple RFP2 mRNA isoforms in the two species that have different 5' UTRs and a human-specific antisense transcript RFP2OS. Since the human RFP2 5' UTR is not conserved in mo
Autor:
Rachel E. Ibbotson, R V Seear, Anne Gardiner, Jenny A. Orchard, Nicholas C.P. Cross, Andrew Chase, L Y Zhang, David Oscier
Publikováno v:
Leukemia. 17:2097-2100
The P2X7 receptor, a plasma membrane ATP-gated ion channel that plays a role in lymphocyte apoptosis, has been suggested as an important contributory factor to the pathogenesis of chronic lymphocytic leukaemia (CLL). The P2X7 gene resides on chromoso
Autor:
Louis M. Staudt, George E. Wright, Adrian Wiestner, Rachel E. Ibbotson, Diane C. Arthur, Todd S. Barry, R. Eric Davis, Mark Raffeld, Wyndham H. Wilson, Jenny A. Orchard, Terry J. Hamblin, Hong Zhao, Gerald E. Marti, Zadie Davis, David Oscier, Andreas Rosenwald, Sarah E. Henrickson, Maryalice Stetler-Stevenson
Publikováno v:
Blood. 101:4944-4951
The presence or absence of somatic mutations in the expressed immunoglobulin heavy chain variable regions (IgVH) of chronic lymphocytic leukemia (CLL) cells provides prognostic information. Patients whose leukemic cells express unmutated IgVH regions
Autor:
Jenny A. Orchard, Terry J. Hamblin, Sarah Mould, Rachel E. Ibbotson, Zadie Davis, Peter Thomas, R. Chapman, David Oscier, Sharron Glide, Anne Gardiner, Martin Corcoran, J. Adrian Copplestone
Publikováno v:
Blood. 100:1177-1184
This study evaluates the prognostic significance of genetic abnormalities (detected at or shortly after presentation), clinical stage, lymphocyte morphology, CD38 expression, and IGVHgene status in 205 patients with chronic lymphocytic leukemia (B-CL
Autor:
Rachel E. Ibbotson, Terry J. Hamblin, Jenny A. Orchard, Peter Thomas, Freda K. Stevenson, Zadie Davis, David Oscier
Publikováno v:
Blood. 99:1023-1029
Although the presence or absence of somatic mutations in the immunoglobulin variable region (IgVH) genes in chronic lymphocytic leukemia (B-CLL) identifies subtypes with very different prognoses, the assay is technically complex and unavailable to mo
Autor:
Gerassimos A. Pangalis, Theodora Papadaki, Neil McIver-Brown, Theodoros P. Vassilakopoulos, Anne Gardiner, Maria K. Angelopoulou, Kostas Stamatopoulos, Penelope Korkolopoulou, Achilles Anagnostopoulos, Christina Kalpadakis, Aliki Xochelli, Zadie Davis, Anastasia Athanasiadou, George Kanellis, Rachel E. Ibbotson, David Oscier, Sarah Mould, Evangelia Stalika, Panagiotis Baliakas, Helen A. Papadaki, Sotirios Sachanas
Publikováno v:
Blood. 123(8)
The biological and clinical significance of a clonal B-cell lymphocytosis with an immunophenotype consistent with marginal-zone origin (CBL-MZ) is poorly understood. We retrospectively evaluated 102 such cases with no clinical evidence to suggest a c