Effect of L-Ergothioneine on the metabolic plasma profile of the RUPP rat model of pre-eclampsia.

Autor: Aude-Claire Morillon, Rachel D Williamson, Philip N Baker, Douglas B Kell, Louise C Kenny, Jane A English, Fergus P McCarthy, Cathal McCarthy

Publikováno v: PLoS ONE, Vol 15, Iss 3, p e0230977 (2020)

IntroductionPre-eclampsia is a major cause of maternal and fetal mortality and morbidity worldwide. Its pathophysiology remains unclear, but mitochondrial dysfunction and oxidative stress have been implicated. L-Ergothioneine is a naturally occurring

Externí odkaz: https://doaj.org/article/c7954483a34a4e88b21d08f42d240a65

L-(+)-Ergothioneine Significantly Improves the Clinical Characteristics of Preeclampsia in the Reduced Uterine Perfusion Pressure Rat Model

Autor: Cathal McCarthy, Rachel D. Williamson, Douglas B. Kell, Emer Groarke, Fergus P. McCarthy, Louise C. Kenny, Samprikta Manna

Publikováno v: HYPERTENSION
Williamson, R D, McCarthy, F P, Manna, S, Groarke, E, Kell, D B, Kenny, L C & McCarthy, C M 2020, ' L-(+)-Ergothioneine Significantly Improves the Clinical Characteristics of Preeclampsia in the Reduced Uterine Perfusion Pressure Rat Model ', Hypertension, vol. 75, no. 2, pp. 561-568 . https://doi.org/10.1161/hypertensionaha.119.13929

Preeclampsia is a multifactorial hypertensive disorder of pregnancy founded on abnormal placentation, and the resultant placental ischemic microenvironment is thought to play a crucial role in its pathophysiology. Placental ischemia because of fluctu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c34db58b2f57e2921c7fd24d789e8631
https://pubmed.ncbi.nlm.nih.gov/31865793

Activation of a TLR9 mediated innate immune response in preeclampsia

Autor: Fergus P. McCarthy, Rachel D. Williamson, Cathal McCarthy, Louise C. Kenny

Publikováno v: SCIENTIFIC REPORTS
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-8 (2019)

Preeclampsia is a multisystemic disorder leading to the development of a placental ischemic microenvironment with a resultant increase in oxidative stress. There is evidence that mitochondrial dysfunction and the innate immune system both play a role

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::922c2c6fbe4dd54174b77991c5423bb2

Magnesium sulphate prevents lipopolysaccharide-induced cell death in an in vitro model of the human placenta

Autor: Cathal McCarthy, Gerard W. O'Keeffe, Louise C. Kenny, Rachel D. Williamson

Publikováno v: Pregnancy hypertension. 6(4)

Objectives To determine if magnesium sulphate (MgSO 4 ) prevents lipopolysaccharide (LPS)-induced cell death in an in vitro model of the human placenta. Study design BeWo choriocarcinoma cells were treated with increasing concentrations of LPS (10–

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df167bc8eb0607238152a1e030060acc
https://pubmed.ncbi.nlm.nih.gov/27939482

O12. Analysis of the molecular and cellular mechanisms regulated by magnesium sulphate in an in vitro model of the human placenta

Autor: Gerard W. O'Keeffe, Rachel D. Williamson, Louise C. Kenny

Publikováno v: Pregnancy Hypertension: An International Journal of Women's Cardiovascular Health. 5:212

Introduction Pre-eclampsia is a multi-systemic pregnancy disorder and characterised as a hypertensive condition which consists of symptoms such as high blood pressure and proteinuria in women in their second trimester (around 20weeks gestation). It g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::258766559f0dc0f2525309b961651a47
https://doi.org/10.1016/j.preghy.2015.07.012