Zobrazeno 1 - 10
of 87
pro vyhledávání: '"Rachel D. Kuns"'
Autor:
Marcela Montes de Oca, Fabian de Labastida Rivera, Clay Winterford, Teija C M Frame, Susanna S Ng, Fiona H Amante, Chelsea L Edwards, Luzia Bukali, Yulin Wang, Jude E Uzonna, Rachel D Kuns, Ping Zhang, Agnieszka Kabat, Ramon I Klein Geltink, Edward J Pearce, Geoffrey R Hill, Christian R Engwerda
Publikováno v:
PLoS Pathogens, Vol 16, Iss 10, p e1008994 (2020)
Inflammation is critical for controlling pathogens, but also responsible for symptoms of infectious diseases. IL-27 is an important regulator of inflammation and can limit development of IFNγ-producing Tbet+ CD4+ T (Th1) cells. IL-27 is thought to d
Externí odkaz:
https://doaj.org/article/d4ce631961bd4ced87a72fbb062a5bf9
Autor:
Geoffrey R. Hill, Motoko Koyama, Mariapia A. Degli-Esposti, Joseph A. Trapani, Kelli P.A. MacDonald, Christian R. Engwerda, Mark J. Smyth, Glen M. Boyle, Kate A. Markey, Slavica Vuckovic, Antiopi Varelias, Greg Kelly, Vivien R. Sutton, Karshing Chang, Jose Paulo Martins, Christopher E. Andoniou, Rachel D. Kuns, Ping Zhang, Siok-Keen Tey, Jason S. Lee, Kate H. Gartlan, Melody Cheong
Supplementary Figure S1: GVHD survival of lethally-irradiated (day 0, 1000cGy split dose) B6.WT, B6.ASC-/- or B6.NLRP3-/- recipients transplanted with BALB/c BM (5x106) and T cells (5x106). The non-GVHD control group received TCD BM cells (5x106) onl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12c670406bdd6e90ec2d85cea9452ca1
https://doi.org/10.1158/2326-6066.22543108
https://doi.org/10.1158/2326-6066.22543108
Autor:
Geoffrey R. Hill, Motoko Koyama, Mariapia A. Degli-Esposti, Joseph A. Trapani, Kelli P.A. MacDonald, Christian R. Engwerda, Mark J. Smyth, Glen M. Boyle, Kate A. Markey, Slavica Vuckovic, Antiopi Varelias, Greg Kelly, Vivien R. Sutton, Karshing Chang, Jose Paulo Martins, Christopher E. Andoniou, Rachel D. Kuns, Ping Zhang, Siok-Keen Tey, Jason S. Lee, Kate H. Gartlan, Melody Cheong
The adaptor protein ASC (apoptosis-associated speck-like protein containing a CARD) is known to facilitate caspase-1 activation, which is essential for innate host immunity via the formation of the inflammasome complex, a multiprotein structure respo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7145b9fd80a40cc0741b069c6d960d1
https://doi.org/10.1158/2326-6066.c.6550138.v1
https://doi.org/10.1158/2326-6066.c.6550138.v1
Autor:
Geoffrey R. Hill, Motoko Koyama, Mariapia A. Degli-Esposti, Joseph A. Trapani, Kelli P.A. MacDonald, Christian R. Engwerda, Mark J. Smyth, Glen M. Boyle, Kate A. Markey, Slavica Vuckovic, Antiopi Varelias, Greg Kelly, Vivien R. Sutton, Karshing Chang, Jose Paulo Martins, Christopher E. Andoniou, Rachel D. Kuns, Ping Zhang, Siok-Keen Tey, Jason S. Lee, Kate H. Gartlan, Melody Cheong
Supplementary Table S1 (related to Fig. 4A): (A) Ingenuity Pathway Analysis derived from the uncorrected dataset displaying top canonical signaling pathways involving differentially regulated genes in recipients as described in Fig.4A. (B) 10 selecte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b81f04af8f07416c8522368ebdbf6e4
https://doi.org/10.1158/2326-6066.22543105.v1
https://doi.org/10.1158/2326-6066.22543105.v1
Autor:
Geoffrey R. Hill, Steven W. Lane, Mariapia A. Degli-Esposti, Thomas Brocker, Gabrielle T. Belz, Raymond J. Steptoe, Mark J. Smyth, Motoko Koyama, Melody Cheong, Simone A. Minnie, Andrea S. Henden, J. Paulo Martins, Renee J. Robb, Kate H. Gartlan, Daniel J. Browne, Rachel D. Kuns, Kate A. Markey
Supplementary table 1: Supplementary Table 1: Gene expression measured in QIAGEN Apoptosis Array; Supplementary Table 2: Antibodies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::042dfc3f266b06f081aef1749f01cb6a
https://doi.org/10.1158/1078-0432.22464882.v1
https://doi.org/10.1158/1078-0432.22464882.v1
Autor:
Geoffrey R. Hill, Steven W. Lane, Mariapia A. Degli-Esposti, Thomas Brocker, Gabrielle T. Belz, Raymond J. Steptoe, Mark J. Smyth, Motoko Koyama, Melody Cheong, Simone A. Minnie, Andrea S. Henden, J. Paulo Martins, Renee J. Robb, Kate H. Gartlan, Daniel J. Browne, Rachel D. Kuns, Kate A. Markey
Purpose: Allogeneic bone marrow transplantation (BMT) provides curative therapy for leukemia via immunologic graft-versus-leukemia (GVL) effects. In practice, this must be balanced against life threatening pathology induced by graft-versus-host disea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2311323d00efc28d48e4bbf248a1df81
https://doi.org/10.1158/1078-0432.c.6525849.v1
https://doi.org/10.1158/1078-0432.c.6525849.v1
Autor:
Simone A. Minnie, Olivia G. Waltner, Kathleen S. Ensbey, Nicole S. Nemychenkov, Christine R. Schmidt, Shruti S. Bhise, Samuel R. W. Legg, Gabriela Campoy, Luke D. Samson, Rachel D. Kuns, Ting Zhou, John D. Huck, Slavica Vuckovic, Danniel Zamora, Albert Yeh, Andrew Spencer, Motoko Koyama, Kate A. Markey, Steven W. Lane, Michael Boeckh, Aaron M. Ring, Scott N. Furlan, Geoffrey R. Hill
Publikováno v:
Sci Immunol
Some hematological malignancies such as multiple myeloma are inherently resistant to immune-mediated antitumor responses, the cause of which remains unknown. Allogeneic bone marrow transplantation (alloBMT) is the only curative immunotherapy for hema
Autor:
William R. Heath, William C. Dougall, Shyam Sundar, Rachel D. Kuns, Jinrui Na, Mika Casey, Shashi Bhushan Chauhan, Alex Loukas, Ashraful Haque, Benjamin A. McEnroe, Nicole Cloonan, Christian R. Engwerda, Dillon Corvino, Eilish Moore, Fabian de Labastida Rivera, Shivangi Wani, Jiajie Hou, Fiona H. Amante, Siddharth Sankar Singh, Nazanin Ghazanfari, Jessica A. Engel, Alan G. Baxter, Juming Yan, Ping Zhang, Megan S. F. Soon, Michele W.L. Teng, Chelsea L. Edwards, Geoffrey R. Hill, Patrick T. Bunn, Yulin Wang, Norelle L. Daly, Tobias Bald, Xian-Yang Li, Rajiv Kumar, Mariapia A. Degli-Esposti, Jude E. Uzonna, Siok-Keen Tey, Mark J. Smyth, Marco J Herold, Marcela Montes de Oca, Matthias Braun, Andrew J. Kueh, Bhawana Singh, Susanna S. Ng, Indrajit Das, Kyohei Nakamura, Amy Roman Aguilera, Om Prakash Singh, Teija C. M. Frame
Publikováno v:
Nature Immunology. 21:1205-1218
Immune-modulating therapies have revolutionized the treatment of chronic diseases, particularly cancer. However, their success is restricted and there is a need to identify new therapeutic targets. Here, we show that natural killer cell granule prote
Autor:
Kate H. Gartlan, Slavica Vuckovic, Karshing Chang, Glen M. Boyle, Vivien R. Sutton, Mark J. Smyth, Melody Cheong, Ping Zhang, Motoko Koyama, Kelli P. A. MacDonald, José Paulo Martins, Christopher E. Andoniou, Joseph A. Trapani, Geoffrey R. Hill, Antiopi Varelias, Greg Kelly, Kate A. Markey, Rachel D. Kuns, Siok-Keen Tey, Mariapia A. Degli-Esposti, Jason Sang Hun Lee, Christian R. Engwerda
Publikováno v:
Cancer Immunology Research. 8:1085-1098
The adaptor protein ASC (apoptosis-associated speck-like protein containing a CARD) is known to facilitate caspase-1 activation, which is essential for innate host immunity via the formation of the inflammasome complex, a multiprotein structure respo
Autor:
Kate L Bowerman, Rachel D. Kuns, Geoffrey R. Hill, Philip Hugenholtz, Nancy Lachner, Antiopi Varelias
Publikováno v:
Gut Microbes
article-version (VoR) Version of Record
article-version (VoR) Version of Record
Objective The gut microbiome plays a key role in the development of acute graft-versus-host disease (GVHD) following allogeneic hematopoietic stem cell transplantation. Here we investigate the individual contribution of the pre- and post-transplant g