Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Rachel D Edgar"'
Autor:
Lisa M McEwen, Meaghan J Jones, David Tse Shen Lin, Rachel D Edgar, Lucas T Husquin, Julia L MacIsaac, Katia E Ramadori, Alexander M Morin, Christopher F Rider, Chris Carlsten, Lluís Quintana-Murci, Steve Horvath, Michael S Kobor
Publikováno v:
Clinical Epigenetics, Vol 10, Iss 1, Pp 1-9 (2018)
Abstract Background The capacity of technologies measuring DNA methylation (DNAm) is rapidly evolving, as are the options for applicable bioinformatics methods. The most commonly used DNAm microarray, the Illumina Infinium HumanMethylation450 (450K a
Externí odkaz:
https://doaj.org/article/c7c9511d89d7403dbd78d2c6ae04b322
Autor:
Kieran J O'Donnell, Vivette Glover, Jari Lahti, Marius Lahti, Rachel D Edgar, Katri Räikkönen, Thomas G O'Connor
Publikováno v:
PLoS ONE, Vol 12, Iss 6, p e0177506 (2017)
Maternal prenatal anxiety is an important risk factor for altered child neurodevelopment but there is uncertainty concerning the biological mechanisms involved and sources of individual differences in children's responses. We sought to determine the
Externí odkaz:
https://doaj.org/article/4402e00e297940648363ff44bd93375b
Autor:
Casey P. Shannon, Travis M. Blimkie, Rym Ben-Othman, Nicole Gladish, Nelly Amenyogbe, Sibyl Drissler, Rachel D. Edgar, Queenie Chan, Mel Krajden, Leonard J. Foster, Michael S. Kobor, William W. Mohn, Ryan R. Brinkman, Kim-Anh Le Cao, Richard H. Scheuermann, Scott J. Tebbutt, Robert E.W. Hancock, Wayne C. Koff, Tobias R. Kollmann, Manish Sadarangani, Amy Huei-Yi Lee
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
BackgroundVaccination remains one of the most effective means of reducing the burden of infectious diseases globally. Improving our understanding of the molecular basis for effective vaccine response is of paramount importance if we are to ensure the
Externí odkaz:
https://doaj.org/article/2b50d5dc445d48949f659ab881399fe1
Culture Associated DNA Methylation Changes Impact on Cellular Function of Human Intestinal Organoids
Autor:
Rachel D Edgar, Francesca Perrone, April R Foster, Felicity Payne, Sophia Lewis, Komal M Nayak, Judith Kraiczy, Aurélie Cenier, Franco Torrente, Camilla Salvestrini, Robert Heuschkel, Kai O Hensel, Rebecca Harris, D. Leanne Jones, Daniel R Zerbino, Matthias Zilbauer
Background & AimsHuman intestinal epithelial organoids (IEO) are a powerful tool to model major aspects of intestinal development, health and diseases, as patient derived cultures retain many features found in-vivo. A necessary aspect of the organoid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c70d852eae9f9e5b1e0975ac83948df8
https://doi.org/10.1101/2022.04.25.489354
https://doi.org/10.1101/2022.04.25.489354
Culture-Associated DNA Methylation Changes Impact on Cellular Function of Human Intestinal Organoids
Autor:
Rachel D. Edgar, Francesca Perrone, April R. Foster, Felicity Payne, Sophia Lewis, Komal M. Nayak, Judith Kraiczy, Aurélie Cenier, Franco Torrente, Camilla Salvestrini, Robert Heuschkel, Kai O. Hensel, Rebecca Harris, D. Leanne Jones, Daniel R. Zerbino, Matthias Zilbauer
Publikováno v:
Cellular and molecular gastroenterology and hepatology. 14(6)
BACKGROUND & AIMS: Human intestinal epithelial organoids (IEOs) are a powerful tool to model major aspects of intestinal development, health, and diseases because patient-derived cultures retain many features found in vivo. A necessary aspect of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::413edc66fbe8a5eb0e186596cdd58927
https://pubmed.ncbi.nlm.nih.gov/36038072
https://pubmed.ncbi.nlm.nih.gov/36038072
Autor:
Megan G. McGill, Jeffrey M. Armstrong, Pathik D. Wadhwa, David T.S. Lin, Tanja Jovanovic, Irina Pokhvisneva, Nancy E. Adler, Michael J. Meaney, Elisabeth B. Binder, Michael S. Kobor, Claudia Buss, Julia L. MacIsaac, Rachel D. Edgar, Katia E Ramadori, Marieke S. Tollenaar, Michelle Z. L. Kee, Kieran J. O’Donnell, Neerja Karnani, Kerry J. Ressler, Sonja Entringer, Torsten Klengel, Nicole R. Bush, Gerald F. Giesbrecht, James N. Reynolds, Nicole Gladish, Meir Steiner, Marilyn J. Essex, Nicole Letourneau, Bekh Bradley, Darina Czamara, Elika Garg, Steve Horvath, Eva Unternaehrer, Lisa M. McEwen, Ronald G. Barr, Carolina de Weerth, Alexander M. Morin, Roseriet Beijers, W. Thomas Boyce, Meaghan J. Jones
Publikováno v:
PNAS, 117(38), 23329-23335
Proc Natl Acad Sci U S A
Proceedings of the National Academy of Sciences of the United States of America, vol 117, iss 38
Proceedings of the National Academy of Sciences USA, 117, 23329-23335
Proceedings of the National Academy of Sciences USA, 117, 38, pp. 23329-23335
Proc Natl Acad Sci U S A
Proceedings of the National Academy of Sciences of the United States of America, vol 117, iss 38
Proceedings of the National Academy of Sciences USA, 117, 23329-23335
Proceedings of the National Academy of Sciences USA, 117, 38, pp. 23329-23335
Contains fulltext : 219496.pdf (Publisher’s version ) (Closed access) DNA methylation is the most studied modification in human population epigenetics. Its information content can be explored in 2 principal ways - epigenome-wide association studies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f38f25c717ad2d4d4c3a8fc780caaf1
https://doi.org/10.1073/pnas.1820843116
https://doi.org/10.1073/pnas.1820843116
Autor:
Calen P Ryan, Meaghan J Jones, Rachel D Edgar, Nanette R Lee, Michael S Kobor, Thomas W McDade, Christopher W Kuzawa
Publikováno v:
Evolution, medicine, and public health. 10(1)
Background Consistent with evolutionarily theorized costs of reproduction (CoR), reproductive history in women is associated with life expectancy and susceptibility to certain cancers, autoimmune disorders and metabolic disease. Immunological changes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67d30e6dc25c4647079390e4c1e49908
https://pubmed.ncbi.nlm.nih.gov/35169479
https://pubmed.ncbi.nlm.nih.gov/35169479
Autor:
Rym Ben-Othman, Bing Cai, Aaron C. Liu, Natallia Varankovich, Daniel He, Travis M. Blimkie, Amy H. Lee, Erin E. Gill, Mark Novotny, Brian Aevermann, Sibyl Drissler, Casey P. Shannon, Sarah McCann, Kim Marty, Gordean Bjornson, Rachel D. Edgar, David Tse Shen Lin, Nicole Gladish, Julia Maclsaac, Nelly Amenyogbe, Queenie Chan, Alba Llibre, Joyce Collin, Elise Landais, Khoa Le, Samantha M. Reiss, Wayne C. Koff, Colin Havenar-Daughton, Manraj Heran, Bippan Sangha, David Walt, Mel Krajden, Shane Crotty, Devin Sok, Bryan Briney, Dennis R. Burton, Darragh Duffy, Leonard J. Foster, William W. Mohn, Michael S. Kobor, Scott J. Tebbutt, Ryan R. Brinkman, Richard H. Scheuermann, Robert E. W. Hancock, Tobias R. Kollmann, Manish Sadarangani
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, 2020, 11, pp.580373. ⟨10.3389/fimmu.2020.580373⟩
Frontiers in Immunology, Frontiers, 2020, 11, pp.580373. ⟨10.3389/fimmu.2020.580373⟩
Frontiers in Immunology, Vol 11 (2020)
Frontiers in Immunology, 2020, 11, pp.580373. ⟨10.3389/fimmu.2020.580373⟩
Frontiers in Immunology, Frontiers, 2020, 11, pp.580373. ⟨10.3389/fimmu.2020.580373⟩
Frontiers in Immunology, Vol 11 (2020)
International audience; Conventional vaccine design has been based on trial-and-error approaches, which have been generally successful. However, there have been some major failures in vaccine development and we still do not have highly effective lice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f8359cde10059cefbc3052a9579fc33
https://hal-pasteur.archives-ouvertes.fr/pasteur-03155985/file/fimmu-11-580373.pdf
https://hal-pasteur.archives-ouvertes.fr/pasteur-03155985/file/fimmu-11-580373.pdf
Autor:
Judith Kraiczy, Matthias Zilbauer, Franco Torrente, Marco Gasparetto, Robert Heuschkel, Yosef Philip-McKenzie, Jack Satsangi, Nicholas T. Ventham, Felicity Payne, Claire Glemas, Daniel R. Zerbino, Rachel D. Edgar, Alexander Ross, Camilla Salvestrini, Rahul Kalla, Komal Nayak, Peter Sarkies
Publikováno v:
Gastroenterology
Background & Aims Gene expression patterns of CD8+ T cells have been reported to correlate with clinical outcomes of adults with inflammatory bowel diseases (IBD). We aimed at validating these findings in independent patient cohorts. Methods We obtai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0919f104964294f126b6170de12b87f
http://europepmc.org/articles/PMC7428744
http://europepmc.org/articles/PMC7428744
Autor:
Komal Nayak, Felicity Payne, Matthias Zilbauer, Glemas C, Franco Torrente, Daniel R. Zerbino, Robert Heuschkel, Judith Kraiczy, Alexander Ross, Rachel D. Edgar, Camilla Salvestrini, Peter Sarkies, Yosef Philip-McKenzie, Marco Gasparetto
Background & AimsCD8+ T-cell gene expression has been implicated in the pathogenesis of Inflammatory Bowel Diseases (IBD) and has been shown to correlate with disease outcome in adult patients. Moreover, CD8+ T-cell exhaustion was identified as a con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd9256e2a165ea8c4cde156e6241a921
https://doi.org/10.1101/2020.03.30.015446
https://doi.org/10.1101/2020.03.30.015446