Výsledky vyhledávání - "Rachel D, Wheeler"

Anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase antibodies: incidence using different testing criteria, and case series

Autor: Vikram M K, Joseph, Emily C, Rose, Christopher J, Edwards, Mark, Lloyd, Soha K, Amar, Rachel D, Wheeler, Tamara, Forster, Karen A, Smith, Efrem, Eren, Rod, Hughes, Vijay, Hajela, Patrick D W, Kiely

Publikováno v: Clinical and Experimental Rheumatology. 40:298-303

To estimate the incidence of anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) antibodies utilising different testing criteria, and review the clinical details of a series of patients with associated autoimmune myopathy.The incidence of an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1cb19732683a207e7aad05ce26f811d
https://doi.org/10.55563/clinexprheumatol/5y19bb

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Case report: Interference from isatuximab on serum protein electrophoresis prevented demonstration of complete remission in a myeloma patient

Autor: Rachel D Wheeler, Micsha V Costa, Asante Crichlow, Fenella Willis, Yasmin Reyal, Sarah E Linstead, Joanne E Morris

Publikováno v: Annals of clinical biochemistry. 59(2)

Multiple myeloma is a haematological cancer caused by malignant plasma cells in the bone marrow that can result in organ dysfunction and death. Recent novel treatments have contributed to improved survival rates, including monoclonal antibody therapi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d4c8d056a7158f5f3f1fa8a35c54e59
https://pubmed.ncbi.nlm.nih.gov/34937410

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P152 The incidence of anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase antibodies may be higher than we think

Autor: Mark Lloyd, Tamara Forster, Patrick D W Kiely, Emily Rose, Soha Khaled Amar, Rachel D Wheeler, Karen A Smith, Vikram M K Joseph, Christopher J Edwards

Publikováno v: Rheumatology. 60

Background/Aims Statins are associated with muscle symptoms, from myalgia with normal CK, to rhabdomyolysis. A sub-group have an autoimmune necrotising myopathy with anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase (anti-HMGCR) antibodies. This c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c530c04aecd3d41eb4b28a5879af4172
https://doi.org/10.1093/rheumatology/keab247.148

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Large abnormal peak on capillary zone electrophoresis due to contrast agent

Autor: Joanna Sheldon, Liqun Zhang, Rachel D Wheeler

Publikováno v: Annals of clinical biochemistry. 55(5)

Background Some iodinated radio-contrast media absorb ultraviolet light and can therefore be detected by capillary zone electrophoresis. If seen, these peaks are typically small with ‘quantifications’ of below 5 g/L. Here, we describe the detecti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3199141e370eb779c83ace59ce7e8a2
https://pubmed.ncbi.nlm.nih.gov/29153027

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Electrophoretic patterns post daratumumab

Autor: Joanna Sheldon, Ray Powles, Rachel D. Wheeler

Publikováno v: Annals of clinical biochemistry. 55(2)

Background Daratumumab (Darzalex) is a human IgG1 kappa monoclonal antibody targeting CD38 that has been recently approved for the treatment of refractory multiple myeloma. As it is a monoclonal protein, it can be detected on routine serum protein el

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b5467ad1b685621eb4c9c9fae94975e
https://pubmed.ncbi.nlm.nih.gov/28490184

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Inflammation in the Central Nervous System and Th17 Responses Are Inhibited by IFN-γ–Induced IL-18 Binding Protein

Autor: Jason M. Millward, Rachel D. Wheeler, Morten Løbner, Trevor Owens

Publikováno v: The Journal of Immunology. 185:2458-2466

Inflammatory responses are essential for immune protection but may also cause pathology and must be regulated. Both Th1 and Th17 cells are implicated in the pathogenesis of autoimmune inflammatory diseases, such as multiple sclerosis. We show in this

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::958f81ca68b3d37a622786d0bbe1b3e0
https://doi.org/10.4049/jimmunol.0902153

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A case study of mixed cryoglobulinaemia associated with peripheral neuropathy

Autor: D Wren, H Sharma, Joanna Sheldon, Rachel D. Wheeler, M Groves

Publikováno v: Annals of Clinical Biochemistry: International Journal of Laboratory Medicine. 44:566-569

The clinical diagnosis of mixed cryoglobulinaemia is difficult due to heterogeneity in presentation. Symptoms include the classical triad of purpura, arthralgia and weakness, with one or more other organs involved. We discuss a case of cryoglobulinae

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::766b3d648462607964e181369445e9e3
https://doi.org/10.1258/000456307782268138

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Interleukin-18 induces expression and release of cytokines from murine glial cells: interactions with interleukin-1β

Autor: Rachel D. Wheeler, Kiyoshi Takeda, Nancy J. Rothwell, Rosalind Le Feuvre, Giamal N. Luheshi, Yoichiro Iwakura, David Brough

Publikováno v: Journal of Neurochemistry. 85:1412-1420

Interleukin (IL)-18, a member of the IL-1 cytokine family, is an important mediator of peripheral inflammation and host defence responses. IL-1 is a key proinflammatory cytokine in the brain, but the role of IL-18 in the CNS is not yet clear. The obj

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::360571a9a318636664963f622095878e
https://doi.org/10.1046/j.1471-4159.2003.01787.x

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