Zobrazeno 1 - 10
of 87
pro vyhledávání: '"Rachel Culp-Hill"'
Autor:
Tanja Eberhart, Federico Uchenna Stanley, Luisa Ricci, Tiziana Chirico, Roberto Ferrarese, Sofia Sisti, Alessandra Scagliola, Andreina Baj, Sylvia Badurek, Andreas Sommer, Rachel Culp-Hill, Monika Dzieciatkowska, Engy Shokry, David Sumpton, Angelo D’Alessandro, Nicola Clementi, Nicasio Mancini, Simone Cardaci
Publikováno v:
Cell Death and Disease, Vol 15, Iss 2, Pp 1-16 (2024)
Abstract Aconitate decarboxylase 1 (ACOD1) is the enzyme synthesizing itaconate, an immuno-regulatory metabolite tuning host-pathogen interactions. Such functions are achieved by affecting metabolic pathways regulating inflammation and microbe surviv
Externí odkaz:
https://doaj.org/article/3cd0e9d0544a4871a65621196c1cf98d
Autor:
Mohd Minhajuddin, Amanda Winters, Haobin Ye, Shanshan Pei, Brett Stevens, Austin Gillen, Krysta Engel, Stephanie Gipson, Monica Ransom, Maria Amaya, Anagha Inguva, Maura Gasparetto, Mark J. Althoff, Regan Miller, Ian Shelton, Hunter Tolison, Anna Krug, Rachel Culp-Hill, Angelo D’Alessandro, Daniel W Sherbenou, Daniel A. Pollyea, Clayton Smith, Craig T Jordan
Publikováno v:
Haematologica, Vol 999, Iss 1 (2024)
The treatment of blast phase chronic myeloid leukemia (bpCML) remains a challenge due at least in part to drug resistance of leukemia stem cells (LSCs). Recent clinical evidence suggests that the BCL-2 inhibitor venetoclax in combination with ABL-tar
Externí odkaz:
https://doaj.org/article/1e698dc2b5034f73b534561525fe0273
Autor:
Cristiana O’Brien, Tianyi Ling, Jacob M. Berman, Rachel Culp-Hill, Julie A. Reisz, Vincent Rondeau, Soheil Jahangiri, Jonathan St-Germain, Vinitha Macwan, Audrey Astori, Andy Zeng, Jun Young Hong, Meng Li, Min Yang, Sadhan Jana, Fabia Gamboni, Emily Tsao, Weiyi Liu, John E. Dick, Hening Lin, Ari Melnick, Anastasia Tikhonova, Andrea Arruda, Mark D. Minden, Brian Raught, Angelo D'Alessandro, Courtney L. Jones
Publikováno v:
Haematologica, Vol 108, Iss 9 (2023)
Outcomes for patients with acute myeloid leukemia (AML) remain poor due to the inability of current therapeutic regimens to fully eradicate disease-initiating leukemia stem cells (LSC). Previous studies have demonstrated that oxidative phosphorylatio
Externí odkaz:
https://doaj.org/article/365041b041f04292a5cd13ba5d068c3d
Autor:
Emily L. Giddings, Devin P. Champagne, Meng-Han Wu, Joshua M. Laffin, Tina M. Thornton, Felipe Valenca-Pereira, Rachel Culp-Hill, Karen A. Fortner, Natalia Romero, James East, Phoebe Cao, Hugo Arias-Pulido, Karatatiwant S. Sidhu, Brian Silverstrim, Yoonseok Kam, Shana Kelley, Mark Pereira, Susan E. Bates, Janice Y. Bunn, Steven N. Fiering, Dwight E. Matthews, Robert W. Robey, Domink Stich, Angelo D’Alessandro, Mercedes Rincon
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Drug efflux through ABC transporters is a common mechanism leading to chemoresistance in cancer. Here, the authors show that mitochondrial respiration provides ATP to allow ABC transporters activity so mitochondrial respiration inhibition overcomes c
Externí odkaz:
https://doaj.org/article/96cc5e262fc1481b86eceff834f1a9ce
Autor:
Rachel Culp-Hill, Brett M. Stevens, Courtney L. Jones, Shanshan Pei, Monika Dzieciatkowska, Mohammad Minhajuddin, Craig T. Jordan, Angelo D’Alessandro
Publikováno v:
Metabolites, Vol 13, Iss 4, p 467 (2023)
Recent advances in targeting leukemic stem cells (LSCs) using venetoclax with azacitidine (ven + aza) has significantly improved outcomes for de novo acute myeloid leukemia (AML) patients. However, patients who relapse after traditional chemotherapy
Externí odkaz:
https://doaj.org/article/65d7f53879dc4307ac50c0ab77af4dac
Autor:
Andrew J. Jezewski, Yu-Hsi Lin, Julie A. Reisz, Rachel Culp-Hill, Yasaman Barekatain, Victoria C. Yan, Angelo D’Alessandro, Florian L. Muller, Audrey R. Odom John
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 11 (2021)
Glycolysis controls cellular energy, redox balance, and biosynthesis. Antiglycolytic therapies are under investigation for treatment of obesity, cancer, aging, autoimmunity, and microbial diseases. Interrupting glycolysis is highly valued as a therap
Externí odkaz:
https://doaj.org/article/22d7e09907934e49a2840c1a4cc95da1
Autor:
Rani K. Powers, Rachel Culp-Hill, Michael P. Ludwig, Keith P. Smith, Katherine A. Waugh, Ross Minter, Kathryn D. Tuttle, Hannah C. Lewis, Angela L. Rachubinski, Ross E. Granrath, María Carmona-Iragui, Rebecca B. Wilkerson, Darcy E. Kahn, Molishree Joshi, Alberto Lleó, Rafael Blesa, Juan Fortea, Angelo D’Alessandro, James C. Costello, Kelly D. Sullivan, Joaquin M. Espinosa
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Down syndrome (DS) is caused by trisomy 21 (T21), but the underlying etiology of the related immune and neurological dysfunction is unclear. Here, the authors show that T21 activates the kynurenine pathway via increased interferon receptor copy numbe
Externí odkaz:
https://doaj.org/article/ab62f68b2f204b5a960385c4c5866d85
Autor:
Heather L. Howie, Ariel M. Hay, Karen de Wolski, Hayley Waterman, Jenna Lebedev, Xiaoyun Fu, Rachel Culp-Hill, Angelo D'Alessandro, James D. Gorham, Matthew S. Ranson, John D. Roback, Peter C. Thomson, James C. Zimring
Publikováno v:
Blood Advances, Vol 3, Iss 15, Pp 2272-2285 (2019)
Abstract: Red blood cells (RBCs) are the most numerous cell type in the body and serve a vital purpose of delivering oxygen to essentially all tissues. In addition to the central role of RBCs in health and disease, RBC storage is a requirement for th
Externí odkaz:
https://doaj.org/article/af97ca379a834d02bbdaa7b73bbe84ad
Autor:
Angelo D'Alessandro, Xiaoyun Fu, Tamir Kanias, Julie A. Reisz, Rachel Culp-Hill, Yuelong Guo, Mark T. Gladwin, Grier Page, Steven Kleinman, Marion Lanteri, Mars Stone, Michael P. Busch, James C. Zimring
Publikováno v:
Haematologica, Vol 106, Iss 5 (2020)
Red blood cell storage in the blood bank promotes the progressive accumulation of metabolic alterations that may ultimately impact the erythrocyte capacity to cope with oxidant stressors. However, the metabolic underpinnings of the capacity of RBCs t
Externí odkaz:
https://doaj.org/article/8a01873d34ad4a95898f59516fd970bb
Autor:
Rachel Culp-Hill, Connie Zheng, Julie A. Reisz, Keith Smith, Angela Rachubinski, Travis Nemkov, Eric Butcher, Ross Granrath, Kirk C. Hansen, Joaquín M. Espinosa, Angelo D'Alessandro
Publikováno v:
Blood Advances, Vol 1, Iss 27, Pp 2776-2780 (2017)
Abstract: Red blood cells (RBCs) are the most abundant cell in the human body. During their ∼120-day life span in the circulatory system, RBCs release oxygen to all human tissues while being exposed to tissue metabolic activity. Owing to the relati
Externí odkaz:
https://doaj.org/article/40373d55374143bd8aed4ec649ea90a5