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Autor:
Rachel Coselmon, Saravanaraj Ayyampalayam, Marina Shalaeva, Pil H. Lee, Lionel A. Carreira, Salwa Poole, Shobha Bhattachar, Franco Lombardo, and Eric Gifford
Publikováno v:
Molecular Pharmaceutics. 4:498-512
Most pharmacologically active molecules contain one or more ionizing groups, and it is well-known that knowledge of the ionization state of a drug, indicated by the pKa value, is critical for understanding many properties important to the drug discov