Pharmacological activation of PIEZO1 in human red blood cells prevents Plasmodium falciparum invasion

Autor: Rakhee Lohia, Benoit Allegrini, Laurence Berry, Hélène Guizouarn, Rachel Cerdan, Manouk Abkarian, Dominique Douguet, Eric Honoré, Kai Wengelnik

Publikováno v: Cellular and Molecular Life Sciences. 80

An inherited gain-of-function variant (E756del) in the mechanosensitive cationic channel PIEZO1 was shown to confer a significant protection against severe malaria. Here, we demonstrate in vitro that human red blood cell (RBC) infection by Plasmodium

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::70296c45ca237e183447e1fb5da1a503
https://doi.org/10.1007/s00018-023-04773-0

β-Hydroxy- and β-Aminophosphonate Acyclonucleosides as Potent Inhibitors of Plasmodium falciparum Growth

Autor: Rachel Cerdan, Thomas Cheviet, Gabriel Bourchenin, Christian Périgaud, Manon Lagacherie, Sharon Wein, Suzanne Peyrottes

Publikováno v: Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, American Chemical Society, 2020, 63 (15), pp.8069-8087. ⟨10.1021/acs.jmedchem.0c00131⟩

Malaria is an infectious disease caused by a parasite of the genus Plasmodium, and the emergence of parasites resistant to all current antimalarial drugs highlights the urgency of having new classes of molecules. We developed an effective method for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00bb5fb0627e01d1b5ef2a25164b9ae0
https://hal.archives-ouvertes.fr/hal-03007532

Structural determinants of the catalytic mechanism of Plasmodium CCT, a key enzyme of malaria lipid biosynthesis

Autor: Gergely N. Nagy, Rachel Cerdan, Yinshan Yang, François Hoh, Jean-François Guichou, Henri Vial, Fanni Hajdú, Beáta G. Vértessy, Ewelina Guca, Lívia Marton, Richard Izrael

Publikováno v: Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
Scientific Reports
'Scientific Reports ', vol: 8, pages: 11215-1-11215-13 (2018)
Scientific Reports, Nature Publishing Group, 2018, 8 (1), ⟨10.1038/s41598-018-29500-9⟩

The development of the malaria parasite, Plasmodium falciparum, in the human erythrocyte, relies on phospholipid metabolism to fulfil the massive need for membrane biogenesis. Phosphatidylcholine (PC) is the most abundant phospholipid in Plasmodium m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3ec05d8dbd2d41ca90041adffa6d92a
https://doi.org/10.1038/s41598-018-29500-9

Comprehensive Analysis of Parasite Biology : From Metabolism to Drug Discovery

Autor: Sylke Müller, Rachel Cerdan, Ovidiu Radulescu

Written and edited by experts in the field, this book brings together the current state of the art in phenotypic and rational, target-based approaches to drug discovery against pathogenic protozoa. The chapters focus particularly on virtual compounds

Biochemical characterization of Plasmodium falciparum CTP:phosphoethanolamine cytidylyltransferase shows that only one of the two cytidylyltransferase domains is active

Autor: Alicia Contet, Emilie Pihan, Rachel Cerdan, Marina Lavigne, Kai Wengelnik, Blandine Alberge, Dominique Douguet, Clemens H. M. Kocken, Henri Vial, Sweta Maheshwari

Publikováno v: Biochemical Journal; Vol 450
Biochemical Journal
Biochemical Journal, Portland Press, 2013, 450 (1), pp.159-167. ⟨10.1042/BJ20121480⟩

The intra-erythrocytic proliferation of the human malaria parasite Plasmodium falciparum requires massive synthesis of PE (phosphatidylethanolamine) that together with phosphatidylcholine constitute the bulk of the malaria membrane lipids. PE is main

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2f2421f677c8388b70e1efd93be985d