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pro vyhledávání: '"Rachel C. Epplin"'
Autor:
Rachel C. Epplin, Shashwati Paul, Loïc Herter, Christophe Salome, Erin N. Hancock, Jay F. Larrow, Erich W. Baum, David R. Dunstan, Carol Ginsburg-Moraff, Thomas C. Fessard, M. Kevin Brown
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-5 (2022)
The development of new classes of isosteres and building blocks is crucial to the advancement of medicinal chemistry programs. Here, the authors report the synthesis and development of ladderanes to act as replacements for meta-substituted aromatic r
Externí odkaz:
https://doaj.org/article/ebd0a84e99d044029fceee6ab73bf297
Autor:
Rachel C. Epplin, Shashwati Paul, Loïc Herter, Christophe Salome, Erin N. Hancock, Jay F. Larrow, Erich W. Baum, David R. Dunstan, Carol Ginsburg-Moraff, Thomas C. Fessard, M. Kevin Brown
Publikováno v:
Nature Communications
Aromatic ring isosteres and rigidified saturated hydrocarbons are important motifs to enable drug discovery. Herein we disclose [2]-ladderanes as a class of meta-substituted aromatic ring isosteres and rigidified cyclohexanes. A straightforward synth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::704a6408ecb9323c10f1b4ad9e111357