Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Rachel C. Childers"'
Autor:
Binata Joddar, Michael S Firstenberg, Rashmeet K Reen, Saradhadevi Varadharaj, Mahmood Khan, Rachel C Childers, Jay L Zweier, Keith J Gooch
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0120301 (2015)
Saphenous veins used as arterial grafts are exposed to arterial levels of oxygen partial pressure (pO2), which are much greater than what they experience in their native environment. The object of this study is to determine the impact of exposing hum
Externí odkaz:
https://doaj.org/article/ececd30ea95a4e7aa44188596b0df137
Autor:
Rachel C. Childers, Pamela A. Lucchesi, Ian Sunyecz, Keith J. Gooch, Mary J. Cismowski, T. Aaron West
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 316:H596-H608
Hemodynamic load regulates cardiac remodeling. In contrast to pressure overload (increased afterload), hearts subjected to volume overload (VO; preload) undergo a distinct pattern of eccentric remodeling, chamber dilation, and decreased extracellular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5c0971d3042e5d74619b8c05fd7bc00
https://doi.org/10.1152/ajpheart.00095.2018
https://doi.org/10.1152/ajpheart.00095.2018
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 6231, p 6231 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 12
International Journal of Molecular Sciences
Volume 22
Issue 12
A hypofibrotic phenotype has been observed in cardiac fibroblasts (CFs) isolated from a volume overload heart failure model, aortocaval fistula (ACF). This paradoxical phenotype results in decreased ECM synthesis despite increased TGF-β presence. Si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e1fdb976718b5639eda954063424327
https://www.mdpi.com/1422-0067/22/12/6231
https://www.mdpi.com/1422-0067/22/12/6231
Publikováno v:
Journal of biomechanical engineering. 143(8)
Pressure overload (PO) and volume overload (VO) of the heart result in distinctive changes to geometry, due to compensatory structural remodeling. This remodeling potentially leads to changes in tissue mechanical properties. Understanding such change
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a95499e91e6a0b4f94c9513944695e1b
https://pubmed.ncbi.nlm.nih.gov/33729495
https://pubmed.ncbi.nlm.nih.gov/33729495
Autor:
Lauren E Evans, Ean G Beyer, Kar Ming Fung, Yi Wu, Jacob Richardson, Anju R Babu, Rheal A. Towner, Colton J. Ross, Rachel C. Childers, Harold M. Burkhart, Chung-Hao Lee, Arshid Mir, Devin W. Laurence, Gerhard Holzapfel
Publikováno v:
J R Soc Interface
The atrioventricular heart valve (AHV) leaflets have a complex microstructure composed of four distinct layers: atrialis, ventricularis, fibrosa and spongiosa. Specifically, the spongiosa layer is primarily proteoglycans and glycosaminoglycans (GAGs)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4955f5cff4c2a80e94bf15a4dcb2bb3
https://doi.org/10.1098/rsif.2019.0069
https://doi.org/10.1098/rsif.2019.0069
Publikováno v:
The FASEB Journal. 29
Objective: Determine whether substrate stiffness contributes to the hypo-fibrotic phenotype of cardiac fibroblasts (CFs) isolated from a volume overload heart failure model. Methods: Primary (P0) C...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8562d38884a1891cdd103e1014a68e45
https://doi.org/10.1096/fasebj.29.1_supplement.1045.3
https://doi.org/10.1096/fasebj.29.1_supplement.1045.3
Autor:
Saradhadevi Varadharaj, Rashmeet K. Reen, Jay L. Zweier, Binata Joddar, Rachel C. Childers, Mahmood Khan, Keith J. Gooch, Michael S. Firstenberg
Publikováno v:
PLoS ONE
PLoS ONE, Vol 10, Iss 3, p e0120301 (2015)
PLoS ONE, Vol 10, Iss 3, p e0120301 (2015)
Saphenous veins used as arterial grafts are exposed to arterial levels of oxygen partial pressure (pO2), which are much greater than what they experience in their native environment. The object of this study is to determine the impact of exposing hum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a679248b51214106874ce2b82756c1e6
https://pubmed.ncbi.nlm.nih.gov/25799140
https://pubmed.ncbi.nlm.nih.gov/25799140
Autor:
Rachel C. Childers, Keith J. Gooch, Xiaojin Zhang, T. Aaron West, Maarten L. Galantowicz, John C. Weibel, Pamela A. Lucchesi, Mary J. Cismowski
Publikováno v:
The FASEB Journal. 27
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::67d805c4dce48a2d6e63253125efdbbd
https://doi.org/10.1096/fasebj.27.1_supplement.1129.15
https://doi.org/10.1096/fasebj.27.1_supplement.1129.15