Výsledky vyhledávání - "Rachel C, Skirrow"

Effects of Acute Exposure to the Non-steroidal Anti-inflammatory Drug Ibuprofen on the Developing North American Bullfrog (Rana catesbeiana) Tadpole

Autor: Graham van Aggelen, Caren C. Helbing, Rachel C. Skirrow, Lorraine Brown, Nik Veldhoen

Publikováno v: Environmental Science & Technology. 48:10439-10447

A variety of pharmaceutical chemicals can represent constituents of municipal effluent outflows that are dispersed into aquatic receiving environments worldwide. Increasingly, there is concern as to the potential of such bioactive substances to inter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9b120c6b8ec8183ad3b65aee5388ced
https://doi.org/10.1021/es502539g

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Effect of low dose exposure to the herbicide atrazine and its metabolite on cytochrome P450 aromatase and steroidogenic factor-1 mRNA levels in the brain of premetamorphic bullfrog tadpoles (Rana catesbeiana)

Autor: Rachel C. Skirrow, Nik Veldhoen, Wei Ding, Mark P. Gunderson, Graham van Aggelen, Caren C. Helbing, Magnus K. Macnab

Publikováno v: Aquatic Toxicology. 102:31-38

The transcriptional regulator steroidogenic factor 1 (SF-1) and the enzyme cytochrome P450 aromatase (CYP19) play a central role in modulation of a broad range of tissue-specific developmental processes associated with hormone homeostasis that includ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95d16e2abef8492704784b3785b2a445
https://doi.org/10.1016/j.aquatox.2010.12.019

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Nanometals Induce Stress and Alter Thyroid Hormone Action in Amphibia at or below North American Water Quality Guidelines

Autor: Graham van Aggelen, Jay T. Cullen, Rachel C. Skirrow, Caren C. Helbing, Nik Veldhoen, Ashley Hinther, Patricia Collins, Saadia Vawda

Publikováno v: Environmental Science & Technology. 44:8314-8321

Nanometals are manufactured to particle sizes with diameters in the nanometer range and are included in a variety of consumer and health products. There is a lack of information regarding potential effects of these materials on aquatic organisms. Amp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcdaa81b939879187082d15fbb977447
https://doi.org/10.1021/es101902n

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Roscovitine inhibits thyroid hormone-induced tail regression of the frog tadpole and reveals a role for cyclin C/Cdk8 in the establishment of the metamorphic gene expression program

Autor: Rachel C. Skirrow, Caren C. Helbing, Dominik Domanski, Nik Veldhoen

Publikováno v: Developmental Dynamics. 237:3787-3797

The involvement of phosphorylation signaling pathways in postembryonic development of the frog is poorly understood. The thyroid hormone, 3, 5, 3′-triiodothyronine (T3), is essential for inducing tadpole metamorphosis and we show that the cyclin-de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd45ad9fa4091613b57a496faaf14b95
https://doi.org/10.1002/dvdy.21800

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Genistein prevents thyroid hormone-dependent tail regression ofRana catesbeiana tadpoles by targetting protein kinase C and thyroid hormone receptor α

Autor: Dominik Domanski, Caren C. Helbing, Lan Ji, Rachel C. Skirrow

Publikováno v: Developmental Dynamics. 236:777-790

Thyroid hormone (TH)-regulated gene expression is mainly mediated by TH binding to nuclear thyroid hormone receptors (TRs). Despite extensive studies in mammalian cell lines that show that phosphorylation signaling pathways are important in TH action

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68e5b4301efbcf609c4024da6dafd85a
https://doi.org/10.1002/dvdy.21088

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Evaluating the treatment of a synthetic wastewater containing a pharmaceutical and personal care product chemical cocktail: compound removal efficiency and effects on juvenile rainbow trout

Autor: Graham van Aggelen, Christopher J. Kennedy, Rachel C. Skirrow, Eric R. Hall, Caren C. Helbing, Mehrnoush Mohammadali, Heather L. Osachoff, Lorraine Brown

Publikováno v: Water research. 62

Pharmaceutical and personal care products (PPCPs) can evade degradation in sewage treatment plants (STPs) and can be chronically discharged into the environment, causing concern for aquatic organisms, wildlife, and humans that may be exposed to these

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83c0c0912aca2df7cce60d7c89323ff8
https://pubmed.ncbi.nlm.nih.gov/24963889

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Minimally invasive transcriptome profiling in salmon: detection of biological response in rainbow trout caudal fin following exposure to environmental chemical contaminants

Autor: Graham van Aggelen, Nik Veldhoen, Cynthia L. Meays, Mitchel R. Stevenson, Caren C. Helbing, Kevin J. Rieberger, Rachel C. Skirrow

Publikováno v: Aquatic toxicology (Amsterdam, Netherlands).

An increasing number of anthropogenic chemicals have demonstrated potential for disruption of biological processes critical to normal growth and development of wildlife species. Both anadromous and freshwater salmon species are at risk of exposure to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0da1a6d6819cf03031f19ac97e6fda29
https://pubmed.ncbi.nlm.nih.gov/24055988

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Triclosan exposure alters postembryonic development in a Pacific tree frog (Pseudacris regilla) Amphibian Metamorphosis Assay (TREEMA)

Autor: Kurtis Vallée, Dannika Bakker, Bonnie P. Lo, Caren C. Helbing, Graham van Aggelen, James R. Elphick, Vicki L. Marlatt, Rachel C. Skirrow, Dayue Shang, Maxine Haberl, Nik Veldhoen, Vicki Rehaume

Publikováno v: Aquatic toxicology (Amsterdam, Netherlands). 126

The Amphibian Metamorphosis Assay (AMA), developed for Xenopus laevis, is designed to identify chemicals that disrupt thyroid hormone (TH)-mediated biological processes. We adapted the AMA for use on an ecologically-relevant North American species, t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b94518742ab5ecc0468a79777917c5e9
https://pubmed.ncbi.nlm.nih.gov/23159728

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