Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Rachel Bayley"'
Publikováno v:
Molecular & Cellular Oncology, Vol 5, Iss 6 (2018)
We recently identified that methylation of lysine 4 of histone H3 (H3K4) by SETD1A (SET domain containing 1A) maintains genome stability by protecting newly-replicated DNA from degradation. Mechanistically, SETD1A-dependent histone methylation regula
Externí odkaz:
https://doaj.org/article/a22138b6aaf7462cad98829af88a3986
Publikováno v:
Cancer Drug Resistance. 6:35-44
The clinical treatment of DNA-repair defective tumours has been revolutionised by the use of poly(ADP) ribose polymerase (PARP) inhibitors. However, the efficacy of these compounds is hampered by resistance, which is attributed to numerous mechanisms
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::33ecbb8736a925718189ebe24726a2ba
https://doi.org/10.20517/cdr.2022.73
https://doi.org/10.20517/cdr.2022.73
Autor:
Paloma García, Eva Petermann, Grant S. Stewart, Martin R. Higgs, Manoj Raghavan, Natasha Reeve, Jidnyasa Gujar, Ruba Almaghrabi, Carl Ward, Giacomo Volpe, Stephanie Dumon, Laila Cancian, Daniel Blakemore, Rachel Bayley
Gene expression analysis comapring Mybl2 high vs Mybl2 low
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6aa54c3261aeb9fb9f28f43122f1bbf3
https://doi.org/10.1158/0008-5472.22420002.v1
https://doi.org/10.1158/0008-5472.22420002.v1
Autor:
Paloma García, Eva Petermann, Grant S. Stewart, Martin R. Higgs, Manoj Raghavan, Natasha Reeve, Jidnyasa Gujar, Ruba Almaghrabi, Carl Ward, Giacomo Volpe, Stephanie Dumon, Laila Cancian, Daniel Blakemore, Rachel Bayley
Seven supplementary figures. Figure S1. Proliferation capacity of expanded CD34+ cells purified from MDS patient PBMC samples.Figure S2. Absolute numbers of bone marrow stem cell subpopulations in wild type and Mybl2 deficient animals.Figure S3. Recr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c48093b556c7c44522d83e35df9d674
https://doi.org/10.1158/0008-5472.22420005.v1
https://doi.org/10.1158/0008-5472.22420005.v1
Autor:
Paloma García, Eva Petermann, Grant S. Stewart, Martin R. Higgs, Manoj Raghavan, Natasha Reeve, Jidnyasa Gujar, Ruba Almaghrabi, Carl Ward, Giacomo Volpe, Stephanie Dumon, Laila Cancian, Daniel Blakemore, Rachel Bayley
Myelodysplastic syndromes (MDS) are a heterogeneous group of diseases characterized by blood cytopenias that occur as a result of somatic mutations in hematopoietic stem cells (HSC). MDS leads to ineffective hematopoiesis, and as many as 30% of patie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::deb8328e1edb0569a4384280fafa56d8
https://doi.org/10.1158/0008-5472.c.6510528.v1
https://doi.org/10.1158/0008-5472.c.6510528.v1
Autor:
Rachel Bayley, Valerie Borel, Rhiannon J. Moss, Ellie Sweatman, Philip Ruis, Alice Ormrod, Amalia Goula, Rachel M.A. Mottram, Tyler Stanage, Graeme Hewitt, Marco Saponaro, Grant S. Stewart, Simon J. Boulton, Martin R. Higgs
The 53BP1-RIF1-shieldin pathway maintains genome stability by suppressing nucleolytic degradation of DNA ends at double-strand breaks (DSBs). Although RIF1 interacts with damaged chromatin via phospho-53BP1 and facilitates recruitment of the shieldin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe3d5a86e0285b048acc6ca1696c3aa3
Publikováno v:
Biochimica et biophysica acta. Reviews on cancer. 1874(2)
The MYBL2 gene, also known as B-MYB, is essential to regulate vital cellular processes including cell proliferation, differentiation and DNA repair. Changes in these pathways can facilitate cancer development and as such targeting these processes rep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59747ab359371e61a593a66ca78cdcbc
https://pubmed.ncbi.nlm.nih.gov/32853735
https://pubmed.ncbi.nlm.nih.gov/32853735
Publikováno v:
Journal of Tissue Engineering and Regenerative Medicine. 12:e368-e378
Manufacture of red blood cells (RBCs) from progenitors has been proposed as a method to reduce reliance on donors. Such a process would need to be extremely efficient for economic viability given a relatively low value product and high 2E12 cell dose
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0cdc9bf794920dc8c0cad6edd97e9df2
https://doi.org/10.1002/term.2337
https://doi.org/10.1002/term.2337
Autor:
Rachel Bayley
Publikováno v:
DNA Repair and Replication ISBN: 9780429464744
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ac23b6904421c2a1728f4d2fc0623702
https://doi.org/10.1201/9780429464744-14
https://doi.org/10.1201/9780429464744-14
Publikováno v:
Oncotarget
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8aa53111568f687743de52536595ee87
https://doi.org/10.18632/oncotarget.26477
https://doi.org/10.18632/oncotarget.26477