Ruxolitinib, a JAK1/2 Inhibitor, Ameliorates Cytokine Storm in Experimental Models of Hyperinflammation Syndrome

Autor: Eduardo Huarte, Michael T. Peel, Katherine Verbist, Brittany L. Fay, Rachel Bassett, Sabrin Albeituni, Kim E. Nichols, Paul A. Smith

Publikováno v: Frontiers in Pharmacology, Vol 12 (2021)

Hyperinflammatory syndromes comprise a heterogeneous group of disorders characterized by severe inflammation, multiple organ dysfunction, and potentially death. In response to antigenic stimulus (e.g., SARS-CoV-2 infection), overactivated CD8+ T-cell

Externí odkaz: https://doaj.org/article/df02de8b70a848108cbd1aee78cceb38

JAK/STAT pathway inhibition sensitizes CD8 T cells to dexamethasone-induced apoptosis in hyperinflammation

Autor: Heather Tillman, Brooks Scull, Katherine Verbist, Carl E. Allen, Lauren K. Meyer, Michelle L. Hermiston, Rachel Bassett, Alexa N. Stroh, Kim E. Nichols, Sabrin Albeituni

Publikováno v: Blood. 136:657-668

Cytokine storm syndromes (CSS) are severe hyperinflammatory conditions characterized by excessive immune system activation leading to organ damage and death. Hemophagocytic lymphohistiocytosis (HLH), a disease often associated with inherited defects

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6344f3823a149439d0c3fff18180c220
https://doi.org/10.1182/blood.2020006075

AN EXAMINATION OF ADVANCED CARE PLANNING IN BLACK AMERICANS: DIRECTION TO IMPROVE ENGAGEMENT

Autor: Rachel Bassett, Daniel Paulson, Nicole Valdes McClure

Publikováno v: Innovation in Aging. 6:862-862

Past studies have found that older Black Americans are less likely to establish advance care directives (ACDs) than their White age peers, and medical distrust has been identified as one possible cause. Others have suggested the formulaic approach of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::427aadc3f8c2ca578013128da3078723
https://doi.org/10.1093/geroni/igac059.3083

Synthesis and Biological Studies of (+)-Liquiditerpenoic Acid A (Abietopinoic Acid) and Representative Analogues: SAR Studies

Autor: Steffen Hering, José M. Padrón, Fatima Rivas, Miguel A. González-Cardenete, Damir Hamulić, Rachel Bassett, M. Auxiliadora Dea-Ayuela, Marco Stadler, Marco A. Loza-Mejía

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
CEU Repositorio Institucional
Fundación Universitaria San Pablo CEU (FUSPCEU)

The first semisynthesis and biological profiling of the new abietane diterpenoid (+)-liquiditerpenoic acid A (abietopinoic acid) (7) along with several analogues are reported. The compounds were obtained from readily available methyl dehydroabietate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98655bbd286c50cab2c7c155dac489f7
https://doi.org/10.1021/acs.jnatprod.8b00884

Ruxolitinib, a JAK1/2 Inhibitor, Ameliorates Cytokine Storm in Experimental Models of Hyperinflammation Syndrome

Autor: Michael Peel, Rachel Bassett, Katherine Verbist, Kim E. Nichols, Sabrin Albeituni, Eduardo Huarte, Brittany Fay, Paul A. Smith

Publikováno v: Frontiers in Pharmacology
Frontiers in Pharmacology, Vol 12 (2021)

Hyperinflammatory syndromes comprise a heterogeneous group of disorders characterized by severe inflammation, multiple organ dysfunction, and potentially death. In response to antigenic stimulus (e.g., SARS-CoV-2 infection), overactivated CD8+ T-cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c30f487046b78dfa8c538d8847778cf6
https://pubmed.ncbi.nlm.nih.gov/33981229