An essential thioredoxin-type protein of Trypanosoma brucei acts as redox-regulated mitochondrial chaperone.

Autor: Rachel B Currier, Kathrin Ulrich, Alejandro E Leroux, Natalie Dirdjaja, Matías Deambrosi, Mariana Bonilla, Yasar Luqman Ahmed, Lorenz Adrian, Haike Antelmann, Ursula Jakob, Marcelo A Comini, R Luise Krauth-Siegel

Publikováno v: PLoS Pathogens, Vol 15, Iss 9, p e1008065 (2019)

Most known thioredoxin-type proteins (Trx) participate in redox pathways, using two highly conserved cysteine residues to catalyze thiol-disulfide exchange reactions. Here we demonstrate that the so far unexplored Trx2 from African trypanosomes (Tryp

Externí odkaz: https://doaj.org/article/760db50775bb44a9a0ccbc05aa1486bd

Cathepsin-L can resist lysis by human serum in Trypanosoma brucei brucei.

Autor: Sam Alsford, Rachel B Currier, José Afonso Guerra-Assunção, Taane G Clark, David Horn

Publikováno v: PLoS Pathogens, Vol 10, Iss 5, p e1004130 (2014)

Closely related African trypanosomes cause lethal diseases but display distinct host ranges. Specifically, Trypanosoma brucei brucei causes nagana in livestock but fails to infect humans, while Trypanosoma brucei gambiense and Trypanosoma brucei rhod

Externí odkaz: https://doaj.org/article/da03d8ad19eb4e579a26b5e1dbf72188

Decoding the network of Trypanosoma brucei proteins that determines sensitivity to apolipoprotein-L1

Autor: Hollie Burrell-Saward, Annette MacLeod, Rachel B. Currier, Anneli Cooper, Sam Alsford

Publikováno v: PLoS Pathogens
PLoS Pathogens, Vol 14, Iss 1, p e1006855 (2018)

In contrast to Trypanosoma brucei gambiense and T. b. rhodesiense (the causative agents of human African trypanosomiasis), T. b. brucei is lysed by apolipoprotein-L1 (apoL1)-containing human serum trypanolytic factors (TLF), rendering it non-infectio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12ddac112898f807abe24f11da8dc6c8
http://europepmc.org/articles/PMC5790291

An essential thioredoxin-type protein of Trypanosoma brucei acts as redox-regulated mitochondrial chaperone

Autor: Mariana Bonilla, Marcelo A. Comini, Matías Deambrosi, Haike Antelmann, Natalie Dirdjaja, Yasar Luqman Ahmed, Lorenz Adrian, Ursula Jakob, Rachel B. Currier, Alejandro E. Leroux, Kathrin Ulrich, R. Luise Krauth-Siegel

Publikováno v: PLoS Pathogens
COLIBRI
Universidad de la República
instacron:Universidad de la República
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
PLoS Pathogens, Vol 15, Iss 9, p e1008065 (2019)

Most known thioredoxin-type proteins (Trx) participate in redox pathways, using two highly conserved cysteine residues to catalyze thiol-disulfide exchange reactions. Here we demonstrate that the so far unexplored Trx2 from African trypanosomes (Tryp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1479757250d326147bf104a57ad754d5
https://doi.org/10.1371/journal.ppat.1008065

The king cobra genome reveals dynamic gene evolution and adaptation in the snake venom system

Autor: Ryan J.R. McCleary, Mark Yandell, Wolfgang Wüster, A. P. Jason de Koning, Diego Calderon, Asad S. Hyder, Harald M. E. Kerkkamp, Jessica M. Logan, R. Manjunatha Kini, Denis Duboule, Walter Pirovano, Guido van den Thillart, Anthony E. Woods, Libia Sanz, Freek J. Vonk, José M. C. Ribeiro, Rachel B. Currier, Nicholas R. Casewell, Alysha Heimberg, Christiaan V. Henkel, Herman P. Spaink, Robert A. Harrison, Ron P. Dirks, Hans J. Jansen, Todd A. Castoe, David D. Pollock, Isabel Guerreiro, Rutger A. Vos, Camila Renjifo, David Salgado, Davinia Pla, Edwina McGlinn, Jan W. Arntzen, Marten Boetzer, Juan J. Calvete, Michael K. Richardson

Publikováno v: Europe PubMed Central
Proceedings of the National Academy of Sciences
Proceedings of the National Academy of Sciences, 110(51), 20651-20656

Snakes are limbless predators, and many species use venom to help overpower relatively large, agile prey. Snake venoms are complex protein mixtures encoded by several multilocus gene families that function synergistically to cause incapacitation. To

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ead0bb18eefd47610ed5a3af7706c776
https://hdl.handle.net/1887/55328