Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Rachel Abbotts"'
Autor:
Anna J. Dellomo, Rachel Abbotts, Christian L. Eberly, Mariusz Karbowski, Maria R. Baer, Tami J. Kingsbury, Feyruz V. Rassool
Publikováno v:
Translational Oncology, Vol 15, Iss 1, Pp 101283- (2022)
Signal transducer and activator of transcription 5 (STAT5) signaling plays a pathogenic role in both hematologic malignancies and solid tumors. In acute myeloid leukemia (AML), internal tandem duplications of fms-like tyrosine kinase 3 (FLT3-ITD) con
Externí odkaz:
https://doaj.org/article/1a37956d049b40a797eb0d03b6d03d1b
Autor:
Srinivasan Madhusudan, Ian O. Ellis, Emad A. Rakha, Stephen Chan, Graham Ball, Claire Seedhouse, Nada Albarakati, Claire Hawkes, Rachel Abbotts, Tarek Abdel-Fatah, Rebeka Sultana
PDF file - 322K, Supplemental Figure 1. Disease free survival (DFS) and distant metastasis free survival (DMFS) in breast cancer whole cohort (A), Lymph node negative (B) and lymphnode positive (C). Supplemental Figure 2. Disease free survival (DFS)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41fffd69f6d1fd9f31806f6ebc8b79ed
https://doi.org/10.1158/0008-5472.22400370.v1
https://doi.org/10.1158/0008-5472.22400370.v1
Supplementary Tables 1 - 4 from Targeting XRCC1 Deficiency in Breast Cancer for Personalized Therapy
Autor:
Srinivasan Madhusudan, Ian O. Ellis, Emad A. Rakha, Stephen Chan, Graham Ball, Claire Seedhouse, Nada Albarakati, Claire Hawkes, Rachel Abbotts, Tarek Abdel-Fatah, Rebeka Sultana
PDF file - 104K, Supplemental Table S1: Clinicopathological characteristics of whole breast cancer cohort Supplemental Table S2: Clinicopathological characteristics of validation setSupplementary Table S3: Antigens, primary antibodies, clone, source,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a34a3e894a3aec930036ca634262cad
https://doi.org/10.1158/0008-5472.22400367.v1
https://doi.org/10.1158/0008-5472.22400367.v1
Autor:
Srinivasan Madhusudan, Ian O. Ellis, Emad A. Rakha, Stephen Chan, Graham Ball, Claire Seedhouse, Nada Albarakati, Claire Hawkes, Rachel Abbotts, Tarek Abdel-Fatah, Rebeka Sultana
XRCC1 is a key component of DNA base excision repair, single strand break repair, and backup nonhomologous end-joining pathway. XRCC1 (X-ray repair cross-complementing gene 1) deficiency promotes genomic instability, increases cancer risk, and may ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9b22245bc2a92ca79a34d8f7ef73c8ae
https://doi.org/10.1158/0008-5472.c.6505569
https://doi.org/10.1158/0008-5472.c.6505569
Publikováno v:
Cancers. 14(11)
The poly(ADP-ribose) polymerase (PARP) family of proteins has been implicated in numerous cellular processes, including DNA repair, translation, transcription, telomere maintenance, and chromatin remodeling. Best characterized is PARP1, which plays a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a5f4f1ff23d55b0e95430e65333b157e
https://pubmed.ncbi.nlm.nih.gov/35681619
https://pubmed.ncbi.nlm.nih.gov/35681619
Autor:
Aksinija A. Kogan, Eun Yong Choi, Lena McLaughlin, Stephen B. Baylin, Rachel Abbotts, Feyruz V. Rassool, Michael J. Topper, Christopher Biondi, Reena Goswami, Javed Mahmood, Lora Stojanovic, Daniel Fontaine, Rena G. Lapidus, Limin Xia
Publikováno v:
Proceedings of the National Academy of Sciences. 116:22609-22618
A minority of cancers have breast cancer gene (BRCA) mutations that confer sensitivity to poly (ADP-ribose) polymerase (PARP) inhibitors (PARPis), but the role for PARPis in BRCA-proficient cancers is not well established. This suggests the need for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef49fd00298ac70bddce2a709f6b9bce
https://doi.org/10.1073/pnas.1903765116
https://doi.org/10.1073/pnas.1903765116
Autor:
Rachel Abbotts, Lora Stojanovic, Michael J. Topper, Brian M. Polster, Stephen B. Baylin, Feyruz V. Rassool
Publikováno v:
Cancer Research. 82:5593-5593
DNA methyltransferase inhibitors (DNMTis) modulate genome-wide methylation patterns, previously linked by our group to downregulation of DNA double strand break repair (DSBR) that sensitizes non-small cell lung cancer (NSCLC) to poly(ADP-ribose) poly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a6ced7dd050747244569f076cdeda391
https://doi.org/10.1158/1538-7445.am2022-5593
https://doi.org/10.1158/1538-7445.am2022-5593
Autor:
Rachel Abbotts, David M. Wilson
Publikováno v:
Free Radical Biology and Medicine. 107:228-244
The genetic material of all organisms is susceptible to modification. In some instances, these changes are programmed, such as the formation of DNA double strand breaks during meiotic recombination to generate gamete variety or class switch recombina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac99de19248b8ee78959c8d08bbbb987
https://doi.org/10.1016/j.freeradbiomed.2016.11.039
https://doi.org/10.1016/j.freeradbiomed.2016.11.039
Autor:
Ying Wang, Gemma S. Puts, Benjamin A. Portney, Mary Kathryn Leonard, Rachel Abbotts, Lena McLaughlin, David M. Kaetzel, Feyruz V. Rassool, Stuart G. Jarrett, Nicolette Matsangos, Michal Zalzman, Richard Vincent, Devin Snyder
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 5896, p 5896 (2020)
International Journal of Molecular Sciences
Volume 21
Issue 16
International Journal of Molecular Sciences
Volume 21
Issue 16
Reduced NME1 expression in melanoma cell lines, mouse models of melanoma, and melanoma specimens in human patients is associated with increased metastatic activity. Herein, we investigate the role of NME1 in repair of double-stranded breaks (DSBs) an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::776884b0c72905536bab453d55a52eb5
https://doi.org/10.3390/ijms21165896
https://doi.org/10.3390/ijms21165896
The human genome is under constant stress from thousands of DNA damage lesions that are formed as indirect products of endogenous metabolic or enzymatic processes, or generated from exposure to exogenous environmental physical and chemical agents. A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3a2a110beef6f16a840bfca249514372
https://doi.org/10.1016/b978-0-12-801238-3.65170-x
https://doi.org/10.1016/b978-0-12-801238-3.65170-x