Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Rachel A. Toroni"'
Autor:
Erika von Euw, Olivia M. Lucero, Randall T. Moon, Rima M. Kulikauskas, Georgina V. Long, Lauren E. Haydu, Jamie N. Anastas, Rachel A. Toroni, Hsiao Wang Chen, Pei-Tzu Yang, Andy J. Chien, Tigist Tamir, Helen Rizos
Publikováno v:
Journal of Clinical Investigation. 124:2877-2890
About half of all melanomas harbor a mutation that results in a constitutively active BRAF kinase mutant (BRAF(V600E/K)) that can be selectively inhibited by targeted BRAF inhibitors (BRAFis). While patients treated with BRAFis initially exhibit meas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac20d033fa69f3bdfba7127a85645ab3
https://doi.org/10.1172/jci70156
https://doi.org/10.1172/jci70156
Autor:
Chirayu P. Goswami, Mircea Ivan, George W. Sledge, Rachel A. Toroni, Bogdan Tanasa, Usha Sirimalle, Kerry L. Sanders, Yesim Gökmen-Polar, Changyu Shen, Sunil Badve, Rutika Mehta, Lang Li
Publikováno v:
Journal of Cancer
Bevacizumab, the recombinant antibody targeting vascular endothelial growth factor (VEGF), improves progression-free but not overall survival in metastatic breast cancer. To seek further insights in resistance mechanisms to bevacizumab at the molecul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b604a6f49b5ce592a16e427a03a11dd3
https://doi.org/10.7150/jca.8466
https://doi.org/10.7150/jca.8466
Autor:
Richard G. James, Priska D. von Haller, Katherine A. Bosch, Andy J. Chien, Jason D. Berndt, Nicholas C. Robin, Pei-Tzu Yang, Rima M. Kulikauskas, Randall T. Moon, Travis L. Biechele, Alejandro Wolf-Yadlin, Jimmy K. Eng, Rachel A. Toroni
Publikováno v:
The Journal of Biological Chemistry
Background: Wnt/β-catenin signaling inhibits melanoma cell viability. Results: Integration of phosphoproteomics and RNA interference screens querying the Wnt/β-catenin pathway reveals protein kinase N1 as an inhibitor of signaling. Conclusion: Prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1162422abeee1c4a1cc035a7cbfcd546
http://europepmc.org/articles/PMC3843078
http://europepmc.org/articles/PMC3843078
Autor:
Pei-Tzu Yang, Jamie N. Anastas, Michi M. Shinohara, Anja K. Bosserhoff, Rachel A. Toroni, Andy J. Chien, Jamie M. Goodson, Randall T. Moon
Publikováno v:
EMBO Molecular Medicine
Elevated levels of nuclear β-catenin are associated with higher rates of survival in patients with melanoma, raising questions as to how ß-catenin is regulated in this context. In the present study, we investigated the formal possibility that the s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b420d514ac8235f488bb2a9f2f4cfebb
https://doi.org/10.1002/emmm.201201486
https://doi.org/10.1002/emmm.201201486
Autor:
Changyu Shen, Barbara A. Hocevar, Yesim Gökmen-Polar, Kathy D. Miller, Rachel A. Toroni, Elizabeth Bruckheimer, Michael S. Kinch, Qianqian Zhao, Sunil Badve
Publikováno v:
Breast Cancer Research and Treatment. 127:375-384
Overexpression and altered function of EphA2 receptor tyrosine kinase are critical in the progression of breast cancer and provide a target for breast cancer therapy. We have previously demonstrated that EphA2 overexpression decreases estrogen depend
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3a2abd64b9ea122a590b481e086e980
https://doi.org/10.1007/s10549-010-1004-y
https://doi.org/10.1007/s10549-010-1004-y
Autor:
Yesim Gökmen-Polar, Rachel A. Toroni, George W. Sledge, Christian Rommel, Rutika Mehta, Sunil Badve, Kerry L. Sanders, Yi Liu
Publikováno v:
Breast cancer research and treatment. 136(3)
Aberrant activation of the mammalian target of rapamycin (mTOR) signaling plays an important role in breast cancer progression and represents a potential therapeutic target for breast cancer. In this study, we report the impact of the investigational
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c15bf53cc75d356abb888cdf1667dd5
https://pubmed.ncbi.nlm.nih.gov/23085766
https://pubmed.ncbi.nlm.nih.gov/23085766
Autor:
Rachel A. Toroni, Richard G. James, Nicholas C. Robin, Rima M. Kulikauskas, Olivia M. Lucero, Andy J. Chien, Reyna D. Swift, Randall T. Moon, Travis L. Biechele, David W. Dawson
As the Wnt/β-catenin signaling pathway is linked to melanoma pathogenesis and to patient survival, we conducted a kinome siRNA screen in melanoma cells to expand our understanding of kinases that regulate this pathway, and to illuminate potential th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35153d18a2af1033eb2e14dd3b084af9
https://europepmc.org/articles/PMC3297477/
https://europepmc.org/articles/PMC3297477/
Autor:
Changyu Shen, Rachel A. Toroni, Kerry L. Sanders, Chirayu Goswami, Rutika Mehta, Yesim Gökmen-Polar, G. W. Sledge, Sunil Badve, Usha Sirimalle, Mircea Ivan, Lang Li, Bogdan Tanasa
Publikováno v:
Cancer Research. 71:P5-06
Background: Bevacizumab, a monoclonal antibody targeting vascular endothelial growth factor (VEGF), had promising therapeutic efficacy in breast cancer. However, intrinsic or acquired resistance is common in the clinic. To improve our understanding o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a2345f6eca9e659d3eecf9cb6b3f6a35
https://doi.org/10.1158/0008-5472.sabcs11-p5-06-01
https://doi.org/10.1158/0008-5472.sabcs11-p5-06-01
Autor:
Sunil Badve, Mircea Ivan, Kerry L. Sanders, Yesim Gökmen-Polar, U Sirimalle, Rutika Mehta, Lang Li, Chirayu P. Goswami, Rachel A. Toroni, George W. Sledge
Publikováno v:
Cancer Research. 71:P3-04
Background: Anti-vascular endothelial growth factor (anti-VEGF) therapy improves disease-free but not overall survival in metastatic breast cancer. To seek further insight on resistance to anti-VEGF antibody bevacizumab (BEV) at the molecular level,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b06ab845168aa928a0d679b812b43055
https://doi.org/10.1158/0008-5472.sabcs11-p3-04-02
https://doi.org/10.1158/0008-5472.sabcs11-p3-04-02
Autor:
Elizabeth Bruckheimer, Kathy D. Miller, Sunil Badve, Yesim Gökmen-Polar, Kinch, Rachel A. Toroni
Publikováno v:
Cancer Research. 69:3020
Abstract #3020 Background: Overexpression and altered function of EphA2 receptor tyrosine kinase are critical in the progression of breast cancer and provide a novel target for breast cancer therapy. We have previously demonstrated that EphA2 overexp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::365adc7864fff99311a0cb8b0113e80e
https://doi.org/10.1158/0008-5472.sabcs-3020
https://doi.org/10.1158/0008-5472.sabcs-3020