Výsledky vyhledávání - "Rachel A. S. Kjolby"

High-throughput fetal fraction amplification increases analytical performance of noninvasive prenatal screening

Autor: Mark R. Theilmann, Rachel A. S. Kjolby, Diana Jeon, Kevin R. Haas, Dale Muzzey, Clement Chu, Helen Y. Wan, James D. Goldberg, Noah C. Welker, Albert Lee

Publikováno v: Genetics in Medicine

Purpose The percentage of a maternal cell-free DNA (cfDNA) sample that is fetal-derived (the fetal fraction; FF) is a key driver of the sensitivity and specificity of noninvasive prenatal screening (NIPS). On certain NIPS platforms, >20% of women wit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8026220f29284eb56c79d3c38d48c50
https://doi.org/10.1038/s41436-020-01009-5

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High-throughput fetal-fraction amplification increases analytical performance of noninvasive prenatal screening

Autor: Dale Muzzey, Kevin R. Haas, James D. Goldberg, Rachel A. S. Kjolby, Noah C. Welker, Mark R. Theilmann, Clement Chu, Albert Lee, Helen Y. Wan, Diana Jeon

PurposeThe percentage of a maternal cell-free DNA (cfDNA) sample that is fetal-derived (the fetal fraction; FF) is a key driver of the sensitivity and specificity of noninvasive prenatal screening (NIPS). On certain NIPS platforms, >20% of women with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08cfff66a3f9afc93b47fdf556fd645e
https://doi.org/10.1101/2020.07.12.20034926

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664 High-throughput fetal-fraction amplification increases analytical performance of noninvasive prenatal screening

Autor: Kevin R. Haas, Rachel A. S. Kjolby, Albert Lee, Mark R. Theilmann, Clement Chu, James D. Goldberg, Helen Y. Wan, Dale Muzzey, Noah C. Welker, Diana Jeon

Publikováno v: American Journal of Obstetrics and Gynecology. 224:S417-S418

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9a132a5a0ce577a6ccd215e3a8253f31
https://doi.org/10.1016/j.ajog.2020.12.688

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Integration of Wnt and FGF signaling in the Xenopus gastrula at TCF and Ets binding sites shows the importance of short range repression in patterning the marginal zone

Autor: Rachel A. S. Kjolby, Marta Truchado-Garcia, Richard M. Harland, Suvruta Iruvanti

Publikováno v: Development

During Xenopus gastrulation, Wnt and FGF signaling pathways cooperate to induce posterior structures. Wnt target expression around the blastopore falls into two main categories: a horseshoe shape with a dorsal gap, like Wnt8 expression, or a ring, li

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2004a69956909185b12ca3f4b64970ae
https://doi.org/10.1242/dev.179580

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Dimerization quality control ensures neuronal development and survival

Autor: Elijah L. Mena, Richard M. Harland, Michael Rape, Brandon G. Lew, Rachel A. S. Kjolby, John M. Boyle, Achim Werner, Robert A. Saxton

Publikováno v: Science (New York, N.Y.). 362(6411)

A way to prevent deadly interaction Many metazoan proteins form oligomers, which is often mediated by modular domains such as BTB domains. Mena et al. now describe a quality control pathway they term dimerization quality control (DQC) (see the Perspe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bc8c038646f2316bd63f1d9c2ee1729
https://pubmed.ncbi.nlm.nih.gov/30327555

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Noggin is required for first pharyngeal arch differentiation in the frog Xenopus tropicalis

Autor: John J. Young, Gloria Wu, Shu-wei Hsu, Richard M. Harland, Daniel Wong, Rachel A. S. Kjolby

Publikováno v: Developmental biology, vol 426, iss 2

The dorsal ventral axis of vertebrates requires high BMP activity for ventral development and inhibition of BMP activity for dorsal development. Presumptive dorsal regions of the embryo are protected from the ventralizing activity of BMPs by the secr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01f10b22a294b3195d65c62ecbc4ffdb
https://escholarship.org/uc/item/978835ct

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Genome-wide identification of Wnt/β-catenin transcriptional targets during Xenopus gastrulation

Autor: Rachel A. S. Kjolby, Richard M. Harland

Publikováno v: Developmental biology, vol 426, iss 2

The canonical Wnt/β-catenin signaling pathway plays multiple roles during Xenopus gastrulation, including posteriorization of the neural plate, patterning of the mesoderm, and induction of the neural crest. Wnt signaling stabilizes β-catenin, which

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e65be8e556dea0f2e7af422811682569
https://escholarship.org/uc/item/4k46j5ks

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Spalt-like 4 promotes posterior neural fates via repression of pou5f3 family members in Xenopus

Autor: Rachel A. S. Kjolby, Stefanie D. Monica, John J. Young, Richard M. Harland, Nikki R. Kong

Publikováno v: Development (Cambridge, England). 141(8)

Amphibian neural development occurs as a two-step process: (1) induction specifies a neural fate in undifferentiated ectoderm; and (2) transformation induces posterior spinal cord and hindbrain. Signaling through the Fgf, retinoic acid (RA) and Wnt/�

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a20cbe5dc53e761958a1ed41397f55a
https://pubmed.ncbi.nlm.nih.gov/24715458

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