Zobrazeno 1 - 10
of 165
pro vyhledávání: '"Rachel A. Perry"'
Autor:
Yuichi Ohashi, Clinton D. Protack, Yukihiko Aoyagi, Luis Gonzalez, Carly Thaxton, Weichang Zhang, Masaki Kano, Hualong Bai, Bogdan Yatsula, Rafael Alves, Katsuyuki Hoshina, Eric B. Schneider, Xiaochun Long, Rachel J. Perry, Alan Dardik
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract Clinical outcomes of arteriovenous fistulae (AVF) for hemodialysis remain inadequate since biological mechanisms of AVF maturation and failure are still poorly understood. Aortocaval fistula creation (AVF group) or a sham operation (sham gro
Externí odkaz:
https://doaj.org/article/6d1010d949bb4f7e835adae694179729
Autor:
Tumininu S Faniyan, Xinyi Zhang, Donald A Morgan, Jorge Robles, Siresha Bathina, Paul S Brookes, Kamal Rahmouni, Rachel J Perry, Kavaljit H Chhabra
Publikováno v:
eLife, Vol 12 (2024)
The kidneys facilitate energy conservation through reabsorption of nutrients including glucose. Almost all the filtered blood glucose is reabsorbed by the kidneys. Loss of glucose in urine (glycosuria) is offset by an increase in endogenous glucose p
Externí odkaz:
https://doaj.org/article/2e669bfd729a4fe8806b8a45fdb3a01b
Autor:
Ngan K. Vu, Rachel J. Perry
Publikováno v:
Clinical and Translational Discovery, Vol 4, Iss 2, Pp n/a-n/a (2024)
Externí odkaz:
https://doaj.org/article/0f3f48f52c374189bab1ab7c55c852ef
Autor:
Xinyi Zhang, Alexandra A. Halberstam, Wanling Zhu, Brooks P. Leitner, Durga Thakral, Marcus W. Bosenberg, Rachel J. Perry
Publikováno v:
Cancer & Metabolism, Vol 10, Iss 1, Pp 1-15 (2022)
Abstract Background Research about tumor “metabolic flexibility”—the ability of cells to toggle between preferred nutrients depending on the metabolic context—has largely focused on obesity-associated cancers. However, increasing evidence for
Externí odkaz:
https://doaj.org/article/734fa890ebb94da9bb588507745e7ac0
Autor:
Ngozi D Akingbesote, Brooks P Leitner, Daniel G Jovin, Reina Desrouleaux, Dennis Owusu, Wanling Zhu, Zongyu Li, Michael N Pollak, Rachel J Perry
Publikováno v:
eLife, Vol 12 (2023)
Metabolic scaling, the inverse correlation of metabolic rates to body mass, has been appreciated for more than 80 years. Studies of metabolic scaling have largely been restricted to mathematical modeling of caloric intake and oxygen consumption, and
Externí odkaz:
https://doaj.org/article/c0cee30591584ce4a8b22589547cbf9a
Autor:
Ngozi D. Akingbesote, Aaron Norman, Wanling Zhu, Alexandra A. Halberstam, Xinyi Zhang, Julia Foldi, Maryam B. Lustberg, Rachel J. Perry
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-11 (2022)
Mice with breast cancer driven by mutations upstream of the PI3K/Akt insulin signaling pathway are found to be responsive to dapagliflozin, while those driven by mutations downstream of PI3K/Akt or in pathways with other driver mutations did not.
Externí odkaz:
https://doaj.org/article/ae03b9310d4d4c888cc4ce0be0a28bb3
Autor:
Brooks P. Leitner, Kevin B. Givechian, Shyryn Ospanova, Aray Beisenbayeva, Katerina Politi, Rachel J. Perry
Publikováno v:
npj Precision Oncology, Vol 6, Iss 1, Pp 1-10 (2022)
Abstract Immunometabolism within the tumor microenvironment is an appealing target for precision therapy approaches in lung cancer. Interestingly, obesity confers an improved response to immune checkpoint inhibition in non-small cell lung cancer (NSC
Externí odkaz:
https://doaj.org/article/3cfdbbc9a9d241b4ab20b7b2c129ff8b
Publikováno v:
PLoS ONE, Vol 18, Iss 10, p e0292678 (2023)
L-type Amino Acid Transporter 1 (LAT1) facilitates the uptake of specific essential amino acids, and due to this quality, it has been correlated to worse patient outcomes in various cancer types. However, the relationship between LAT1 and various cli
Externí odkaz:
https://doaj.org/article/a106563652404a6791cced168d464398
Autor:
Brooks P Leitner, Won D Lee, Wanling Zhu, Xinyi Zhang, Rafael C Gaspar, Zongyu Li, Joshua D Rabinowitz, Rachel J Perry
Publikováno v:
PLoS ONE, Vol 18, Iss 7, p e0286525 (2023)
Reprogramming metabolism is of great therapeutic interest for reducing morbidity and mortality during sepsis-induced critical illness. Disappointing results from randomized controlled trials targeting glutamine and antioxidant metabolism in patients
Externí odkaz:
https://doaj.org/article/7025dcbc0b0b490abb9be4ddee4bb5fc
Publikováno v:
PLoS ONE, Vol 18, Iss 2, p e0281252 (2023)
CPT1A is a rate-limiting enzyme in fatty acid oxidation and is upregulated in high-risk breast cancer. Obesity and menopausal status' relationship with breast cancer prognosis is well established, but its connection with fatty acid metabolism is not.
Externí odkaz:
https://doaj.org/article/32e4b24a254a46239c09feca62208038