Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Rachel A. Mooney"'
Publikováno v:
mBio, Vol 5, Iss 2 (2014)
ABSTRACT Intrinsic terminators, which encode GC-rich RNA hairpins followed immediately by a 7-to-9-nucleotide (nt) U-rich “U-tract,” play principal roles of punctuating and regulating transcription in most bacteria. However, canonical intrinsic t
Externí odkaz:
https://doaj.org/article/97483c40eae04b599fd751b684cea533
Autor:
Rachel E. Mooney, Gerry J. Linden, Lewis Winning, Katie Linden, Frank Kee, Pascal P. McKeown, Jayne V. Woodside, Christopher C. Patterson, Gareth J. McKay
Publikováno v:
PLoS ONE, Vol 17, Iss 8 (2022)
Background Historically, high levels of morbidity and mortality have been associated with cardiovascular disease in the Northern Ireland population. Previously reported associations between single nucleotide polymorphisms (SNPs) and cardiovascular di
Externí odkaz:
https://doaj.org/article/febf55a6f1514ed89e0d55dfa2828e33
Autor:
Sarah K Stumper, Harini Ravi, Larry J Friedman, Rachel Anne Mooney, Ivan R Corrêa Jnr, Anne Gershenson, Robert Landick, Jeff Gelles
Publikováno v:
eLife, Vol 8 (2019)
RNA polymerases (RNAPs) contain a conserved ‘secondary channel’ which binds regulatory factors that modulate transcription initiation. In Escherichia coli, the secondary channel factors (SCFs) GreB and DksA both repress ribosomal RNA (rRNA) trans
Externí odkaz:
https://doaj.org/article/efe9783f6e84415080158b1956a9cb2d
Autor:
Jason Saba, Xien Yu Chua, Tatiana V Mishanina, Dhananjaya Nayak, Tricia A Windgassen, Rachel Anne Mooney, Robert Landick
Publikováno v:
eLife, Vol 8 (2019)
Transcriptional pausing underlies regulation of cellular RNA biogenesis. A consensus pause sequence that acts on RNA polymerases (RNAPs) from bacteria to mammals halts RNAP in an elemental paused state from which longer-lived pauses can arise. Althou
Externí odkaz:
https://doaj.org/article/24639bf2d563493da405524c788c5de8
Autor:
Hande Boyaci, James Chen, Mirjana Lilic, Margaret Palka, Rachel Anne Mooney, Robert Landick, Seth A Darst, Elizabeth A Campbell
Publikováno v:
eLife, Vol 7 (2018)
Fidaxomicin (Fdx) is an antimicrobial RNA polymerase (RNAP) inhibitor highly effective against Mycobacterium tuberculosis RNAP in vitro, but clinical use of Fdx is limited to treating Clostridium difficile intestinal infections due to poor absorption
Externí odkaz:
https://doaj.org/article/ed35d087085b40cab9518a2253b5c555
Autor:
Hannah Steinert, Florian Sochor, Anna Wacker, Janina Buck, Christina Helmling, Fabian Hiller, Sara Keyhani, Jonas Noeske, Steffen Grimm, Martin M Rudolph, Heiko Keller, Rachel Anne Mooney, Robert Landick, Beatrix Suess, Boris Fürtig, Jens Wöhnert, Harald Schwalbe
Publikováno v:
eLife, Vol 6 (2017)
In bacteria, the regulation of gene expression by cis-acting transcriptional riboswitches located in the 5'-untranslated regions of messenger RNA requires the temporal synchronization of RNA synthesis and ligand binding-dependent conformational refol
Externí odkaz:
https://doaj.org/article/9ca65ffa9a5e4f31902497f97157d4fa
Autor:
Linlin You, Expery O. Omollo, Chengzhi Yu, Rachel A. Mooney, Jing Shi, Liqiang Shen, Xiaoxian Wu, Aijia Wen, Dingwei He, Yuan Zeng, Yu Feng, Robert Landick, Yu Zhang
Efficient and accurate termination is required for gene transcription in all living organisms. Cellular RNA polymerases (RNAP) in both bacteria and eukaryotes can terminate their transcription through a factor-independent termination pathway (called
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0aced792fdec3ec155e922f7c970564a
https://doi.org/10.1101/2022.08.30.505822
https://doi.org/10.1101/2022.08.30.505822
Autor:
Madeleine Delbeau, Expery O. Omollo, Ruby Froom, Steven Koh, Rachel A. Mooney, Mirjana Lilic, Joshua J. Brewer, Jeremy Rock, Seth A. Darst, Elizabeth A. Campbell, Robert Landick
Publikováno v:
Molecular Cell. 83:1474-1488.e8
Transcriptional pauses mediate regulation of RNA biogenesis. DNA-encoded pause signals trigger elemental pausing by stabilizing a half-translocated (RNA-not-DNA) state and by promoting RNAP swiveling that other factors can enhance. The universal tran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f36ecb0fc4c25bf2f9c9ee03937c10ea
https://doi.org/10.1016/j.molcel.2023.04.007
https://doi.org/10.1016/j.molcel.2023.04.007
Autor:
Rolf Müller, Robert Landick, Mirjana Lilic, Jennifer Herrmann, Rachel A. Mooney, Hande Boyaci, Elizabeth A. Campbell, Nathaniel Braffman, James Chen, Seth A. Darst, Elizabeth A. Hubin
Publikováno v:
Proceedings of the National Academy of Sciences. 117:30423-30432
Rifampicin (Rif) is a first-line therapeutic used to treat the infectious disease tuberculosis (TB), which is caused by the pathogen Mycobacterium tuberculosis (Mtb). The emergence of Rif-resistant (RifR) Mtb presents a need for new antibiotics. Rif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::038f8c5dca67119d2bd0813433e513d7
https://doi.org/10.1073/pnas.2013706117
https://doi.org/10.1073/pnas.2013706117
Autor:
Rachel E. Mooney, Gerry J. Linden, Lewis Winning, Katie Linden, Frank Kee, Pascal P. McKeown, Jayne V. Woodside, Christopher C. Patterson, Gareth J. McKay
Publikováno v:
Mooney, R E, Linden, G J, Winning, L, Linden, K, Kee, F, McKeown, P P, Woodside, J V, Patterson, C C & McKay, G J 2022, ' Association of TGFB1 rs1800469 and BCMO1 rs6564851 with coronary heart disease and IL1B rs16944 with all-cause mortality in men from the Northern Ireland PRIME study ', PLOS ONE, vol. 17, no. 8, e0273333 . https://doi.org/10.1371/journal.pone.0273333
BackgroundHistorically, high levels of morbidity and mortality have been associated with cardiovascular disease in the Northern Ireland population. Previously reported associations between single nucleotide polymorphisms (SNPs) and cardiovascular dis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d36463fb5057248f6cfe3c52f019fd5d
https://pubmed.ncbi.nlm.nih.gov/35994463
https://pubmed.ncbi.nlm.nih.gov/35994463