Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Rachel A. Harding"'
Autor:
Rachel J. Harding, Carl Laflamme, Sara González Bolívar, Aled M. Edwards, Kathleen Southern, Rebeka Fanti, Riham Ayoubi, Charles Alende, Maryam Fotouhi, Renu Chandrasekaran
Publikováno v:
F1000Research, Vol 13 (2024)
Huntingtin encodes a 3144 amino acid protein, with a polyglutamine repeat tract at the N-terminus. Expansion of this repeat tract above a pathogenic threshold of 36 repeats is the causative mutation of Huntington's disease, a neurodegenerative disord
Externí odkaz:
https://doaj.org/article/4a5893b8570c4bb6a47f872075702b74
Autor:
Mandeep K. Mann, Esther Wolf, Madhushika Silva, Haejin Angela Kwak, Brian Wilson, Albina Bolotokova, Derek J. Wilson, Rachel J. Harding, Matthieu Schapira
Publikováno v:
ACS Omega, Vol 9, Iss 1, Pp 917-924 (2023)
Externí odkaz:
https://doaj.org/article/0871270da6ad48a5913b6b4e16b2b174
Autor:
Rachel J Harding, Patrick Bermudez, Alexander Bernier, Michael Beauvais, Pierre Bellec, Sean Hill, Agâh Karakuzu, Bartha M Knoppers, Paul Pavlidis, Jean-Baptiste Poline, Jane Roskams, Nikola Stikov, Jessica Stone, Stephen Strother, CONP Consortium, Alan C Evans
Publikováno v:
PLoS Computational Biology, Vol 19, Iss 7, p e1011230 (2023)
The Canadian Open Neuroscience Platform (CONP) takes a multifaceted approach to enabling open neuroscience, aiming to make research, data, and tools accessible to everyone, with the ultimate objective of accelerating discovery. Its core infrastructur
Externí odkaz:
https://doaj.org/article/821e308d5dce404ca8ebaedfb7bea457
Autor:
Rachel J. Harding, Justin C. Deme, Johannes F. Hevler, Sem Tamara, Alexander Lemak, Jeffrey P. Cantle, Magdalena M. Szewczyk, Nola Begeja, Siobhan Goss, Xiaobing Zuo, Peter Loppnau, Alma Seitova, Ashley Hutchinson, Lixin Fan, Ray Truant, Matthieu Schapira, Jeffrey B. Carroll, Albert J. R. Heck, Susan M. Lea, Cheryl H. Arrowsmith
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-16 (2021)
Harding et al. present a biophysical and structural characterization of the complex between huntingtin (HTT) and HAP40 proteins. They show that the abundance of HAP40 is coupled with that of HTT and that there is greater conformational variety in the
Externí odkaz:
https://doaj.org/article/eb1fd59dd9ce42829c1dde1a83e58ffc
Publikováno v:
F1000Research, Vol 8 (2019)
The fundamental goal of the growing open science movement is to increase the efficiency of the global scientific community and accelerate progress and discoveries for the common good. Central to this principle is the rapid disclosure of research outp
Externí odkaz:
https://doaj.org/article/cf885960601143b1afc5a6cb08d7e21b
Autor:
Rachel J Harding
Publikováno v:
PLoS Biology, Vol 17, Iss 1, p e3000120 (2019)
Transparency lies at the heart of the open lab notebook movement. Open notebook scientists publish laboratory experiments and findings in the public domain in real time, without restrictions or omissions. Research on rare diseases is especially amena
Externí odkaz:
https://doaj.org/article/daed9a0283d84f57ae85e9a13889fbbf
Autor:
Rachel J. Harding, Ivan Franzoni, Mandeep K. Mann, Magdalena M. Szewczyk, Bijan Mirabi, Dominic D.G Owens, Suzanne Ackloo, Alexej Scheremetjew, Kevin A. Juarez-Ornelas, Randy Sanichar, Rachel J. Baker, Christian Dank, Peter J. Brown, Dalia Barsyte-Lovejoy, Vijayaratnam Santhakumar, Matthieu Schapira, Mark Lautens, Cheryl H. Arrowsmith
These data are the R scripts, environments, output used for analyzing chemoproteomics data. The volcano plot shown in the manuscript is based on the DEP R package. To validate the enrichment output from DEP, the proteomics data was also processed wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a1d88eee8c05d3f84ad9eac6e95b802
Autor:
Tamara Maiuri, Carlos Barba Bazan, Rachel J. Harding, Nola Begeja, Tae-In Kam, Lauren M. Byrne, Filipe B. Rodrigues, Monica M. Warner, Kaitlyn Neuman, Muqtasid Mansoor, Mohsen Badiee, Morgan Dasovich, Anthony K. L. Leung, Sara N. Andres, Edward J. Wild, Ted M. Dawson, Valina L. Dawson, Cheryl H. Arrowsmith, Ray Truant
Huntington’s disease (HD) is an autosomal dominant genetic neurodegenerative disease caused by a CAG expansion in theHuntingtin (HTT)gene, translating to an expanded polyglutamine tract in the huntingtin (HTT) protein. Age at disease onset is corre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1310ffef06654ba9e95bead255cc3210
https://doi.org/10.1101/2022.11.23.517669
https://doi.org/10.1101/2022.11.23.517669
Autor:
Matthew G. Alteen, Justin C. Deme, Claudia P. Alvarez, Peter Loppnau, Ashley Hutchinson, Alma Seitova, Renu Chandrasekaran, Eduardo Silva Ramos, Christopher Secker, Mona Alqazzaz, Erich E. Wanker, Susan M. Lea, Cheryl H Arrowsmith, Rachel J. Harding
Huntington’s disease is characterised by CAG expansion in the huntingtin gene above a critical threshold of~35 repeats, resulting in polyglutamine expansion of the huntingtin protein (HTT). The biological role of wildtype HTT and the associated mec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::458913298835c1b12823ff4554202168
https://doi.org/10.1101/2022.11.21.516512
https://doi.org/10.1101/2022.11.21.516512
Autor:
Rachel J Harding, Yuanyun Xie, Nalini Potluri, Cheryl H Arrowsmith, Blair R Leavitt, Douglas Langbehn, Amber L Southwell
Publikováno v:
D: Wet biomarkers.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a0f9c7d0776b1a8e31d5099b7df8d8b7
https://doi.org/10.1136/jnnp-2022-ehdn.60
https://doi.org/10.1136/jnnp-2022-ehdn.60