Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Rachel A. Garlish"'
Autor:
David P. Humphreys, Richard J. K. Taylor, Rachel A. Garlish, Shirley Jane Peters, Perdita E. Barran, Kamila J. Pacholarz, Alistair James Henry
Publikováno v:
Pacholarz, K, Peters, S, Garlish, R, Henry, A, Taylor, R, Humphreys, D & Barran, P 2016, ' Molecular Insights into the Thermal Stability of mAbs with Variable-Temperature Ion-Mobility Mass Spectrometry ', ChemBioChem: a European journal of chemical biology . https://doi.org/10.1002/cbic.201500574
The aggregation of protein-based therapeutics such as monoclonal antibodies (mAbs) can affect the efficacy of the treatment and can even induce effects that are adverse to the patient. Protein engineering is used to shift the mAb away from an aggrega
Autor:
Perdita E. Barran, Rebecca J. Burnley, Luiz Pedro S. de Carvalho, Richard J. K. Taylor, João Pedro Pisco, Massimiliano Porrini, Victoria Ordsmith, Rachel A. Garlish, Thomas A. Jowitt, Kamila J. Pacholarz, Gerald Larrouy-Maumus
Publikováno v:
Pacholarz, K J, Burnley, R J, Jowitt, T A, Ordsmith, V, Pisco, J P, Porrini, M, Larrouy-Maumus, G, Garlish, R A, Taylor, R J, de Carvalho, L P S & Barran, P E 2017, ' Hybrid Mass Spectrometry Approaches to Determine How L-Histidine Feedback Regulates the Enzyzme MtATP-Phosphoribosyltransferase ', Structure (London, England : 1993), vol. 25, no. 5, pp. 730-738 . https://doi.org/10.1016/j.str.2017.03.005
Structure(London, England:1993)
738.e4
Structure(London, England:1993)
738.e4
Summary MtATP-phosphoribosyltransferase (MtATP-PRT) is an enzyme catalyzing the first step of the biosynthesis of L-histidine in Mycobacterium tuberculosis, and proposed to be regulated via an allosteric mechanism. Native mass spectrometry (MS) revea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f6a0ccf0d281dbef7023541d901ef70
https://www.research.manchester.ac.uk/portal/en/publications/hybrid-mass-spectrometry-approaches-to-determine-how-lhistidine-feedback-regulates-the-enzyzme-mtatpphosphoribosyltransferase(c91580c8-e753-4acf-ae73-f64ac8047573).html
https://www.research.manchester.ac.uk/portal/en/publications/hybrid-mass-spectrometry-approaches-to-determine-how-lhistidine-feedback-regulates-the-enzyzme-mtatpphosphoribosyltransferase(c91580c8-e753-4acf-ae73-f64ac8047573).html
Autor:
Alistair James Henry, Kamila J. Pacholarz, Massimiliano Porrini, Perdita E. Barran, Rebecca J. Burnley, Richard J. K. Taylor, Rachel A. Garlish
Publikováno v:
Angewandte Chemie. 126:7899-7903
Collision cross-sections (CCS) of immunoglobulins G1 and G4 have been determined using linear drift-tube ion-mobility mass spectrometry. Intact antibodies and Fc-hinge fragments present with a larger range of CCS than proteins of comparable size. Thi
Autor:
Rebecca J. Burnley, Rachel A. Garlish, Hannah J. Maple, Mark Allen, Richard J. K. Taylor, Olaf Scheibner, Maciej Bromirski, Mark Baumert
Publikováno v:
Rapid Communications in Mass Spectrometry. 28:1561-1568
RATIONALE Non-covalent mass spectrometry (MS) offers considerable potential for protein-ligand screening in drug discovery programmes. However, there are some limitations with the time-of-flight (TOF) instrumentation typically employed that restrict
Autor:
Matthew P. Crump, Harry Mackenzie, Christine E. Prosser, Adam Hold, John Crosby, Daniel James Ford, John Robert Porter, Ian Whitcombe, Richard J. K. Taylor, Rachel A. Garlish, Hannah J. Maple
Publikováno v:
Analytical Chemistry. 85:5958-5964
Atropisomerism of pharmaceutical compounds is a challenging area for drug discovery programs (Angew. Chem., Int. Ed. 2009, 48, 6398-6401). Strategies for dealing with these compounds include raising the energy barrier to atropisomerization in order t
Autor:
Payne Andrew H, Adam Hold, Graham Trevitt, Jeremy Martin Davis, Chloe Edwards, Clare Watkins, Brian Hutchinson, Daniel James Ford, Rachel A. Garlish, John Robert Porter, James D. Turner, Ian Whitcombe, Colin Stubberfield, Ben de Candole
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:1767-1772
The separation of atropisomeric conformers of 1,2,3,4-tetrahydroisoquinoline amide Bcl-2 ligands allowed the identification of the bioactive conformer which was subsequently confirmed by X-ray crystallography.
Autor:
Hannah J, Maple, Olaf, Scheibner, Mark, Baumert, Mark, Allen, Richard J, Taylor, Rachel A, Garlish, Maciej, Bromirski, Rebecca J, Burnley
Publikováno v:
Rapid communications in mass spectrometry : RCM. 28(13)
Non-covalent mass spectrometry (MS) offers considerable potential for protein-ligand screening in drug discovery programmes. However, there are some limitations with the time-of-flight (TOF) instrumentation typically employed that restrict the applic
Publikováno v:
ChemInform. 43
The initial stages of drug discovery are increasingly reliant on development and improvement of analytical methods to investigate protein–protein and protein–ligand interactions. For over 20 years, mass spectrometry (MS) has been recognized as pr
Publikováno v:
Chemical Society reviews. 41(11)
The initial stages of drug discovery are increasingly reliant on development and improvement of analytical methods to investigate protein–protein and protein–ligand interactions. For over 20 years, mass spectrometry (MS) has been recognized as pr
Autor:
John Robert Porter, Richard J. K. Taylor, John Crosby, Matthew P. Crump, Rachel A. Garlish, Hannah J. Maple, Christine E. Prosser, Alistair James Henry, Jeff Kennedy, Ian Whitcombe, Laura Rigau-Roca
Publikováno v:
Journal of medicinal chemistry. 55(2)
Identifying protein-ligand binding interactions is a key step during early-stage drug discovery. Existing screening techniques are often associated with drawbacks such as low throughput, high sample consumption, and dynamic range limitations. The inc