Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Rachel A, Idol"'
Autor:
Rachel A. Idol, Sourav Bhattacharya, Guangming Huang, Zhimin Song, Anna Huttenlocher, Nancy P. Keller, Mary C. Dinauer
Publikováno v:
The Journal of Immunology. 209:1960-1972
Aspergillus fumigatus is an important opportunistic fungal pathogen and causes invasive pulmonary aspergillosis in conditions with compromised innate antifungal immunity, including chronic granulomatous disease, which results from inherited deficienc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1404106de5dcf3916344cb286ec03f06
https://doi.org/10.4049/jimmunol.2200543
https://doi.org/10.4049/jimmunol.2200543
Autor:
Philipp Wiemann, Adi Perevitsky, Fang Yun Lim, Yana Shadkchan, Benjamin P. Knox, Julio A. Landero Figueora, Tsokyi Choera, Mengyao Niu, Andrew J. Steinberger, Marcel Wüthrich, Rachel A. Idol, Bruce S. Klein, Mary C. Dinauer, Anna Huttenlocher, Nir Osherov, Nancy P. Keller
Publikováno v:
Cell Reports, Vol 19, Iss 5, Pp 1008-1021 (2017)
Summary: The Fenton-chemistry-generating properties of copper ions are considered a potent phagolysosome defense against pathogenic microbes, yet our understanding of underlying host/microbe dynamics remains unclear. We address this issue in invasive
Externí odkaz:
https://doaj.org/article/153c382f8c2f412281161132bf7a71b6
Autor:
Sourav Bhattacharya, Rachel A. Idol, Wei Yang, Jorge David Rojas Márquez, Yanan Li, Guangming Huang, Wandy L. Beatty, Jeffrey J. Atkinson, John H. Brumell, Juhi Bagaitkar, Jeffrey A. Magee, Mary C. Dinauer
Publikováno v:
Blood
The leukocyte NADPH oxidase 2 (NOX2) plays a key role in pathogen killing and immunoregulation. Genetic defects in NOX2 result in chronic granulomatous disease (CGD), associated with microbial infections and inflammatory disorders, often involving th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::588c627bbc9e2cf1261fb50c5e1c9584
https://europepmc.org/articles/PMC9101249/
https://europepmc.org/articles/PMC9101249/
Autor:
Andrea L. Bredemeyer, Junedh M. Amrute, Andrew L. Koenig, Rachel A. Idol, Li He, Stephanie A. Luff, Carissa Dege, Jamison M. Leid, Joel D. Schilling, J. Travis Hinson, Mary C. Dinauer, Christopher M. Sturgeon, Kory J. Lavine
Publikováno v:
Development
Tissue-resident macrophages are increasingly recognized as important determinants of organ homeostasis, tissue repair, remodeling and regeneration. Although the ontogeny and function of tissue-resident macrophages has been identified as distinct from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::980bdc3c689d70206ea867e13be8d612
https://pubmed.ncbi.nlm.nih.gov/35178561
https://pubmed.ncbi.nlm.nih.gov/35178561
Autor:
Rachel A Idol, David F Wozniak, Hideji Fujiwara, Carla M Yuede, Daniel S Ory, Stuart Kornfeld, Peter Vogel
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e109768 (2014)
UDP-GlcNAc:lysosomal enzyme N-acetylglucosamine-1-phosphotransferase is an α2β2γ2 hexameric enzyme that catalyzes the synthesis of the mannose 6-phosphate targeting signal on lysosomal hydrolases. Mutations in the α/β subunit precursor gene caus
Externí odkaz:
https://doaj.org/article/2c86718f77f3467eb9dd19a43ebee97a
Autor:
Scott A. Handley, Denise M. Monack, Ta-Chiang Liu, Paul M. Allen, Vladimir E. Diaz-Ochoa, Jonathan Dworkin, Tobias Kerrinnes, Erica L. Sennott, Caihong Wang, Jacqueline M. Kimmey, Renée M. Tsolis, Kelly M. Storek, Gaya K. Amarasinghe, Chandni Desai, Eric Chen, Ashley A. Viehmann Milam, Michael N. Starnbach, Guoyan Zhao, Camaron R. Hole, Jeremy P. Huynh, Christina L. Stallings, Daisy W. Leung, Craig A. Micchelli, Indira U. Mysorekar, Tamara L. Doering, Christine C. Yokoyama, Rachel A. Idol, Sunmin Park, Seungmin Hwang, Mary C. Dinauer, Megan T. Baldridge, Herbert W. Virgin
Publikováno v:
Journal of Biological Chemistry. 293:6022-6038
Germline-encoded receptors recognizing common pathogen-associated molecular patterns are a central element of the innate immune system and play an important role in shaping the host response to infection. Many of the innate immune molecules central t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::37373c955333a5bd97b1c06e5cbba390
https://doi.org/10.1074/jbc.ra117.001246
https://doi.org/10.1074/jbc.ra117.001246
Autor:
Rachel A. Idol, Ning Yu, Mariana J. Kaplan, Lizet J. Perez-Zapata, Monica M. Purmalek, Chaim O. Jacob, Emilia Alina Barbu, Mary C. Dinauer, Jeanette T. Pingel, Dae-Goon Yoo
Publikováno v:
Arthritis & Rheumatology. 69:1647-1660
Objective. We have previously established that NCF2 (Neutrophil cytosolic factor 2) is a lupus predisposing gene and identified lupus patients with point mutations that are predicted to cause reduced NADPH oxidase activity. This study was undertaken
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c5f56565feafe019c25f96661e31048a
https://doi.org/10.1002/art.40141
https://doi.org/10.1002/art.40141
Autor:
Julio A. Landero Figueora, Bruce S. Klein, Rachel A. Idol, Adi Perevitsky, Mary C. Dinauer, Anna Huttenlocher, Philipp Wiemann, Nir Osherov, Marcel Wüthrich, Benjamin P. Knox, Tsokyi Choera, Fang Yun Lim, Mengyao Niu, Yana Shadkchan, Nancy P. Keller, Andrew J. Steinberger
Publikováno v:
Cell Reports, Vol 19, Iss 10, Pp 2174-2176 (2017)
Cell Reports, Vol 19, Iss 5, Pp 1008-1021 (2017)
Cell Reports, Vol 19, Iss 5, Pp 1008-1021 (2017)
Summary: The Fenton-chemistry-generating properties of copper ions are considered a potent phagolysosome defense against pathogenic microbes, yet our understanding of underlying host/microbe dynamics remains unclear. We address this issue in invasive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::177d34a0e39cec059b936c00161b4b32
http://www.sciencedirect.com/science/article/pii/S2211124717307490
http://www.sciencedirect.com/science/article/pii/S2211124717307490
Autor:
Christine C, Yokoyama, Megan T, Baldridge, Daisy W, Leung, Guoyan, Zhao, Chandni, Desai, Ta-Chiang, Liu, Vladimir E, Diaz-Ochoa, Jeremy P, Huynh, Jacqueline M, Kimmey, Erica L, Sennott, Camaron R, Hole, Rachel A, Idol, Sunmin, Park, Kelly M, Storek, Caihong, Wang, Seungmin, Hwang, Ashley, Viehmann Milam, Eric, Chen, Tobias, Kerrinnes, Michael N, Starnbach, Scott A, Handley, Indira U, Mysorekar, Paul M, Allen, Denise M, Monack, Mary C, Dinauer, Tamara L, Doering, Renee M, Tsolis, Jonathan E, Dworkin, Christina L, Stallings, Gaya K, Amarasinghe, Craig A, Micchelli, Herbert W, Virgin
Publikováno v:
The Journal of biological chemistry. 293(16)
Germline-encoded receptors recognizing common pathogen-associated molecular patterns are a central element of the innate immune system and play an important role in shaping the host response to infection. Many of the innate immune molecules central t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::dbc8e8875fab2d72791c4ef269563bb0
https://pubmed.ncbi.nlm.nih.gov/29496999
https://pubmed.ncbi.nlm.nih.gov/29496999
Autor:
Chaim O, Jacob, Ning, Yu, Dae-Goon, Yoo, Lizet J, Perez-Zapata, Emilia Alina, Barbu, Mariana J, Kaplan, Monica, Purmalek, Jeanette T, Pingel, Rachel A, Idol, Mary C, Dinauer
Publikováno v:
Arthritisrheumatology (Hoboken, N.J.). 69(8)
We have previously established that the gene for neutrophil cytosolic factor 2 (NCF-2) predisposes to lupus, and we have identified lupus patients with point mutations that are predicted to cause reduced NADPH oxidase activity. We undertook this stud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::65e394fc72dd2d6e1bd4ab5a93b34346
https://pubmed.ncbi.nlm.nih.gov/28471497
https://pubmed.ncbi.nlm.nih.gov/28471497