Výsledky vyhledávání - "Rachel Skelton"

Formulation of Lipid-Free Polymeric Mesoscale Nanoparticles Encapsulating mRNA

Autor: Rachel Skelton, Arantxa Roach, Lauren E. Prudhomme, Jing Yu Carolina Cen Feng, Pooja Gaikwad, Ryan M. Williams

Publikováno v: Pharmaceutical Research. 39:2699-2707

Nanoparticle-mediated gene therapy has found substantial clinical impact, primarily focused on lipid-based nanoparticles. In comparison with lipid nanoparticles, polymeric particles may have certain advantages such as increased biocompatibility and c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cd43395c858725f530d20cb1adbfd06
https://doi.org/10.1007/s11095-022-03398-5

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Tubular IL-1β Induces Salt Sensitivity in Diabetes by Activating Renal Macrophages

Autor: Luciana C. Veiras, Ellen A. Bernstein, DuoYao Cao, Derick Okwan-Duodu, Zakir Khan, David R. Gibb, Arantxa Roach, Rachel Skelton, Ryan M. Williams, Kenneth E. Bernstein, Jorge F. Giani

Publikováno v: Circ Res

Background: Chronic renal inflammation has been widely recognized as a major promoter of several forms of high blood pressure including salt-sensitive hypertension. In diabetes, IL (interleukin)-6 induces salt sensitivity through a dysregulation of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f46dc290962f3e89e71fdeaec6b4e80f
https://doi.org/10.1161/circresaha.121.320239

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Abstract P1-07-14: Rates of immune infiltration in patients with triple-negative breast cancers by molecular subtype and in patients with inflammatory and non-inflammatory breast cancers

Autor: Kenichi Harano, NT Ueno, Hiroko Masuda, Brian Z. Ring, Stephan W. Morris, Robert S. Seitz, DB Bailey, Rachel Skelton, Hout, A Rao, Yuefan Wang, Wendy A. Woodward, Bora Lim, James M. Reuben

Publikováno v: Cancer Research. 77:P1-07

Background In patients with triple-negative breast cancer (TNBC), tumor-infiltrating lymphocytes (TILs) have been reported to be associated with improved survival. Lehmann et al. identified 6 molecular subtypes of TNBC [basal-like (BL) 1, BL2, mesenc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e1b212e1a09ca514acc84db7c7b597db
https://doi.org/10.1158/1538-7445.sabcs16-p1-07-14

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Rates of immune cell infiltration in patients with triple-negative breast cancer by molecular subtype

Autor: Steven Van Laere, Arvind Rao, Savitri Krishnamurthy, Brian Z. Ring, David R. Hout, Robert S. Seitz, Wendy A. Woodward, Kenichi Harano, Ying Wang, Daniel B. Bailey, Stephan W. Morris, Hiroko Masuda, Rachel Skelton, Naoto T. Ueno, Bora Lim, François Bertucci, James M. Reuben

Publikováno v: PLoS ONE, Vol 13, Iss 10, p e0204513 (2018)
PLoS ONE
PLoS ONE, Public Library of Science, 2018, 13 (10), pp.e0204513. ⟨10.1371/journal.pone.0204513⟩
PLoS ONE, 2018, 13 (10), pp.e0204513. ⟨10.1371/journal.pone.0204513⟩

International audience; In patients with triple-negative breast cancer (TNBC), tumor-infiltrating lymphocytes (TILs) are associated with improved survival. Lehmann et al. identified 4 molecular subtypes of TNBC [basal-like (BL) 1, BL2, mesenchymal (M

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a7315fd5755d82166c260a82126543c
http://europepmc.org/articles/PMC6193579?pdf=render

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Performance of a RT-PCR Assay in Comparison to FISH and Immunohistochemistry for the Detection of ALK in Non-Small Cell Lung Cancer

Autor: David R. Hout, Tracy Tucker, Rosetta Mazzola, Aly Karsan, Frank McMahon, Kasey Lawrence, David L. Saltman, Stephan W. Morris, Brock L. Schweitzer, Mary Lesperance, Rachel Skelton, John Handshoe

Publikováno v: Cancers; Volume 9; Issue 8; Pages: 99
Cancers
Cancers, Vol 9, Iss 8, p 99 (2017)

Patients with lung cancers harboring an activating anaplastic lymphoma kinase (ALK) rearrangement respond favorably to ALK inhibitor therapy. Fluorescence in situ hybridization (FISH) and immunohistochemistry (IHC) are validated and widely used scree

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Novel qPCR screen for efficient and reliable identification of RET fusion-positive non-small cell lung cancer

Autor: Ryan Vincent, Brock L. Schweitzer, Rachel Skelton, Frank McMahon, Rebecca B Smith, David R. Hout, Stephan W. Morris, John Handshoe

Publikováno v: Journal of Clinical Oncology. 33:e22154-e22154

e22154 Background: The REarranged during Transfection (RET) protein is a cell surface receptor tyrosine kinase (RTK) critical for normal cell growth and differentiation; however, genetic alteration...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5adedab77159f32ebee333d53dfa7a25
https://doi.org/10.1200/jco.2015.33.15_suppl.e22154

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Routine Screening for Triple-Negative Adenocarcinoma (TNA) Lung Cancer Patients: A New Hope for a Poor-Prognosis Population

Autor: John Handshoe, Brock L. Schweitzer, Stephan W. Morris, David R. Hout, Kasey Lawrence, Rachel Skelton, Lindsay E. Chatfield

Publikováno v: American Journal of Clinical Pathology. 140:A149-A149

Lung cancer is the main cause of cancer mortality worldwide, 80% of which are non-small cell lung cancer (NSCLC) in type and >50% are adenocarcinoma in histology. Lung adenocarcinomas are mainly driven by three oncogenes, KRAS, EGFR, and ALK, leaving

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ae0f6a42fe2dc4872fa8064e772a0f6d
https://doi.org/10.1093/ajcp/140.suppl1.149

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Abstract 1930: The unknown piece of the pie: Molecular markers in triple-negative lung cancer

Autor: Rachel Skelton, Stephan W. Morris, Kasey Lawrence, Brock L. Schweitzer, Liquan Xue, Lindsay E. Chatfield, John Handshoe, David R. Hout

Publikováno v: Cancer Research. 73:1930-1930

Lung cancer is the main cause of cancer mortality worldwide. Approximately ∼80% of lung cancer cases are non-small cell lung cancer (NSCLC) in type and >50% of NSCLC are adenocarcinoma in histopathology. A shifting paradigm in the field of pulmonar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eff8cb8ab4e74e3fdc947ec7ca34af96
https://doi.org/10.1158/1538-7445.am2013-1930

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